2020
DOI: 10.1038/s41586-020-2503-6
|View full text |Cite
|
Sign up to set email alerts
|

Single-cell lineage tracing unveils a role for TCF15 in haematopoiesis

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

16
193
0

Year Published

2020
2020
2024
2024

Publication Types

Select...
7
1
1

Relationship

0
9

Authors

Journals

citations
Cited by 185 publications
(225 citation statements)
references
References 74 publications
(44 reference statements)
16
193
0
Order By: Relevance
“…Previous studies propose that in myeloablated mice, hematopoiesis tends to stabilize around 22 weeks post-transplant 7,31 while a recent study suggested 16 to 24 weeks 32 ; our data indicates clonal stabilization between 17 to 19 weeks post-transplant. Overall, the clonal repopulation of human HSPC in hu-BLT mice resembles that of mouse HSPC after autologous transplant.…”
Section: Discussionsupporting
confidence: 47%
“…Previous studies propose that in myeloablated mice, hematopoiesis tends to stabilize around 22 weeks post-transplant 7,31 while a recent study suggested 16 to 24 weeks 32 ; our data indicates clonal stabilization between 17 to 19 weeks post-transplant. Overall, the clonal repopulation of human HSPC in hu-BLT mice resembles that of mouse HSPC after autologous transplant.…”
Section: Discussionsupporting
confidence: 47%
“…Molecularly, this HSC state shows a megakaryocytic priming program similar to the one described in the most quiescent long-term HSCs. 37 Functionally, it resembles an activated G(alert) state, previously described in the context of physical injury. 38,39 We propose that the combination of stimulating signals such as ROS and AKT with adaptive mechanisms such as the reinforced FOXO nuclear localization could drive the properties of this HSC state, defined as quiescent and stress-resistant at steady state but poised for activation in regenerative conditions.…”
Section: Discussionmentioning
confidence: 79%
“…Recent results also suggest that MK progenitors can directly derive from the HSC and that some HSC are biased towards the MK/platelet lineage [ 55 ]. It has been suggested that up to 60% of the MKs arise directly from a MK-biased HSC [ 56 ]. The MK progenitors are able to proliferate and will switch from mitosis to endomitosis, an incomplete mitosis related to a failure in cytokinesis leading to a polyploid cell associated with an increase in cell size.…”
Section: Megakaryopoiesis and Its Regulationmentioning
confidence: 99%