Single‐Cell‐Level Microplasma Cancer Therapy

Kim, Jae Young; Wei, Yanzhang; Li, Jinhua; Foy, Paul; Hawkins, Thomas; Ballato, John; Kim, Sung-O

doi:10.1002/smll.201100456

Cited by 82 publications

(52 citation statements)

References 31 publications

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“…It has found applications in display panels [1], industrial processing technology [2], analytical chemistry [3] as well as in biomedicine, especially for treatment of human skin [4], µ-surgery [5] and cancer therapy [6,7].…”

Section: Introductionmentioning

confidence: 99%

Atmospheric pressure plasma activation of PP films with a localized μplasma

Bitar

Cools

Morent

2016

Surface and Coatings Technology

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Section: Introductionmentioning

confidence: 99%

Atmospheric pressure plasma activation of PP films with a localized μplasma

Bitar

Cools

Morent

2016

Surface and Coatings Technology

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“…The plasma bullets confined inside a dielectric tube may result in atmospheric pressure plasma jets or microplasmas, which has attracted considerable interest due to their potential applications for plasma medicine, thin film deposition, light display, and laser sources. [4][5][6][7][8][9][10] Dielectric tube may be utilized to efficiently generate and guide the plasma bullets or ionization waves when an AC voltage or pulsed voltage is applied onto the microelectrodes. 11,12 It has been widely accepted that, the plasma bullets usually appear as a cathode-directed streamer guided by the helium jet in air, and the propagation of an ionization front leads to a rapid increase in plasma density.…”

Section: Introductionmentioning

confidence: 99%

The density and velocity of plasma bullets propagating along one dielectric tube

Xia

et al. 2015

AIP Advances

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This study shows that the propagation of plasma bullets along one dielectric tube is strongly affected by many discharge parameters, such as the waveform of applied voltage (AC or pulsed DC), peak voltage, He flow rate, and the frequency of AC voltage. Analysis indicates that the density and velocity of plasma bullets are mainly determined by the electric field at the front of plasma bullets. These discharge parameters may significantly influence the distribution of plasma potential along the tube, thus control the electric field at the front of plasma bullets and their propagation. An increase in the pulsed DC voltage with its rise time of <40-50 ns can lead to an obvious improvement in the electric field at the front of plasma bullets, resulting in generation of a plasma in the high density gas and a fast propagation of plasma bullets. He flowing through the tube can contribute to the surface diffusion of charged species, and greatly increase the electric field at the front of plasma bullets. During the propagation of plasma bullets, their density is decreased due to the surface recombination of charged species, such as electrons and ions.

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“…The use of atmospheric-pressure plasmas in cancer therapies is drawing attentions since plasmas contain short-lived free radicals including reactive oxygen species (ROS), charged species, and electric fields that can induce apoptosis in tumor cells. [3][4][5][6][7][8][9][10][11] Particularly, APPJs can be utilized in vivo by delivering a lethal dose of plasma to a tumor without harming surrounding healthy tissues. 3,7 Depending on the jet configuration and the electrical excitation, 2, 12-14 the plasma characteristics including heat, charged particle, electric field, and chemically active species may differ significantly.…”

Section: Introductionmentioning

confidence: 99%

“…It has been shown by several groups that the plasma is able to induce death (the programmed death, apoptosis or the necrotic cell rupture) in a number of cancer cell types. [3][4][5][6][7][8][9][10][11][18][19][20][21] Among these, the induction of apoptosis by plasma treatment has proven an intriguing issue. The ROS produced by plasma are considered to be the key constituents that induce apoptosis.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the characteristics of atmospheric pressure plasma jets using different working gases and applications to plasma-cancer cell interactions

et al. 2013

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Atmospheric pressure plasma jets employing nitrogen, helium, or argon gases driven by low-frequency (several tens of kilohertz) ac voltage and pulsed dc voltage were fabricated and characterized. The changes in discharge current, optical emission intensities from reactive radicals, gas temperature, and plume length of plasma jets with the control parameters were measured and compared. The control parameters include applied voltage, working gas, and gas flow rate. As an application to plasma-cancer cell interactions, the effects of atmospheric pressure plasma jet on the morphology and intracellular reactive oxygen species (ROS) level of human lung adenocarcinoma cell (A549) and human bladder cancer cell (EJ) were explored. The experimental results show that the plasma can effectively control the intracellular concentrations of ROS. Although there exist slight differences in the production of ROS, helium, argon, or nitrogen plasma jets are found to be useful in enhancing the intracellular ROS concentrations in cancer cells

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Single‐Cell‐Level Microplasma Cancer Therapy

Cited by 82 publications

References 31 publications

Atmospheric pressure plasma activation of PP films with a localized μplasma

Atmospheric pressure plasma activation of PP films with a localized μplasma

The density and velocity of plasma bullets propagating along one dielectric tube

Comparison of the characteristics of atmospheric pressure plasma jets using different working gases and applications to plasma-cancer cell interactions

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