Abstract:Experimental and clinical observations are advancing immunotherapies to clinical trial in pulmonary arterial hypertension (PAH). However, comprehensive mapping of the immune landscape in and around pulmonary arteries (PAs) in lung tissue is necessary to predict how immune cells might induce pulmonary vascular pathology. While more severe vascular pathology is reported in BMPR2 mutant patients classified as hereditary (H)PAH, the relationship to specific immune cell subsets has not been established. Emerging hi… Show more
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