Single-cell dissection of the obesity-exercise axis in adipose-muscle tissues implies a critical role for mesenchymal stem cells: Cell Metab. 2022 Oct 4;34(10):1578–1593.e6

Abstract

In this research, Yang et al. have done single cell analysis of obesity and exercise interactions to determine the response of mesenchymal stem cells (MSCs) white adipose and skeletal muscle tissue in mice models. The study concluded that, exercise and obesity have reverse effects on extracellular matrix (ECM) and genes involved in circadian rhythms in MSCs.