Single-cell and spatial transcriptomics reveal alterations in trophoblasts at invasion sites and disturbed myometrial immune microenvironment in placenta accreta spectrum disorders
Kaiyuan Ji,
Yunshan Chen,
Xiuyu Pan
et al.
Abstract:Background
Placenta accreta spectrum disorders (PAS) are a severe complication characterized by abnormal trophoblast invasion into the myometrium. The underlying mechanisms of PAS involve a complex interplay of various cell types and molecular pathways. Despite its significance, both the characteristics and intricate mechanisms of this condition remain poorly understood.
Methods
Spatial transcriptomics (ST) and single-cell RNA sequencing (scRNA-seq… Show more
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