Single-cell and bulk RNA sequencing analysis of B cell marker genes in TNBC TME landscape and immunotherapy
Fangrui Zhao,
Chen Zhao,
Tangpeng Xu
et al.
Abstract:ObjectiveThis study amied to investigate the prognostic characteristics of triple negative breast cancer (TNBC) patients by analyzing B cell marker genes based on single-cell and bulk RNA sequencing.MethodsUtilizing single-cell sequencing data from TNBC patients, we examined tumor-associated B cell marker genes. Transcriptomic data from The Cancer Genome Atlas (TCGA) database were used as the foundation for predictive modeling. Independent validation set was conducted using the GSE58812 dataset. Immune cell in… Show more
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