Single-cell analysis of CCR6+ human Th cells reveals varying degrees of the type-17 phenotype, ranging from cells co-expressing to those fully suppressing opposing pathways
Abstract:Previously, we found that human type-17 Th cells from blood are fully contained within the CCR6-expressing subset. We also found positive correlations between levels of expression of CCR6 and levels of other type-17 proteins such as IL-17A/F, IL-22, and CCL20, □□□ negative correlations of CCR6 expression with that of genes/proteins associated with non-type-17 (Th1, Th2, TFH) pathways. In the present study, analysis of single Th cells expressing various levels of CCR6 using cell sorting followed by RT-PCR revea… Show more
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