Single‐blind follow‐up study on the effectiveness of a symbiotic preparation in irritable bowel syndrome

Tsuchiya, Junji; Barreto, Roberta; Okura, R; Kawakita, S; Fesce, E; Marotta, Francesco

doi:10.1111/j.1443-9573.2004.00176.x

Cited by 95 publications

(72 citation statements)

References 41 publications

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“…Two frequently included papers reported studies in children. 49,50 Two were placebo controlled but single-blinded studies, 33,51 one combined acupuncture with probiotic treatment, 46 and one 32 reported microbiota changes from a probiotic trial published before 52 which was already included in our list.…”

Section: Resultsmentioning

confidence: 99%

Probiotic Therapy of the Irritable Bowel Syndrome: Why Is the Evidence Still Poor and What Can Be Done About It?

Mazurak

Broelz²,

Storr

et al. 2015

J Neurogastroenterol Motil

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Background/AimsDespite numerous randomized clinical trials and meta-analyses, there is no increased evidence for the efficacy of probiotics in the treatment of irritable bowel syndrome (IBS). We review this evidence, identify and analyse the reasons for this lack of evidence and propose methodological improvements for future studies. MethodsBased on a literature search, we identified 56 papers that matched the purpose of our analyses. Twenty-seven studies used multi-species bacterial preparations and 29 used single-strain probiotics. They were analysed regarding patients included, treatment duration, probiotic dosage, and outcome measures. ResultsTrials in both groups suffered from heterogeneity with respect to probiotic concentration, duration of treatment, and other methodological issues (crossover design and underpowered studies). This heterogeneity did not allow the application of a meta-analytic approach and a systematic review was therefore performed instead. Multi-strain preparations combined 2 to 8 different bacterial subspecies, mostly lactobacilli or bifidobacteria, and used variable lengths of treatments. Overall, more than 50% of trials presented negative outcomes. The majority of the single-strain probiotic trials employing lactobacilli or Saccharomyces were negative, whereas trials employing bifidobacteria showed positive results. ConclusionsThe heterogeneity of the studies of probiotics in IBS questions the value of meta-analyses. The use of different bacterial strains and different mixtures of these strains, as well as different dosages, are the main contributors to this heterogeneity. Current data provides limited evidence for the efficacy of a small number of single-strain probiotics in IBS (mostly bifidobacteria) and

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Section: Resultsmentioning

confidence: 99%

Probiotic Therapy of the Irritable Bowel Syndrome: Why Is the Evidence Still Poor and What Can Be Done About It?

Mazurak

Broelz²,

Storr

et al. 2015

J Neurogastroenterol Motil

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“…In 2004, Tsuchiya et al [35] published data regarding the utility of the symbiotic mixture SCM-III in 68 consecutive adults with IBS. SCM-III contains not only live bacteria (in this case L. acidophilus, L. helviticus, and Bifidobacterium species) but also specific substrates known as prebiotics that improve microbial growth and survival.…”

Section: "Positive" Articlesmentioning

confidence: 98%

“…These studies have included single species (Lactobacillus GG, L. salivarius, L. reuteri and Bifidobacterium infantis) [33,34•,38], probiotic mixtures [35,36], and symbiotic preparations [32,39]. A single study by Bausserman and Michail [38] addresses the use of probiotics for IBS in children.…”

Section: Recent Studiesmentioning

confidence: 99%

Probiotic use in irritable bowel syndrome

Young

Cash²

2006

Curr Gastroenterol Rep

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Over the past several years, a number of studies have addressed the role of specific strains of bacteria, or combinations thereof, to alleviate certain symptoms of irritable bowel syndrome (IBS). More importantly, the precise factors that contribute to this therapeutic effect, such as modulations in cytokine levels and alterations in colonic motility, are being clarified. This review serves to summarize the evidence for the use of probiotics in the treatment of IBS and to place this information in clinical context. Potential future developments and areas of possible research are also discussed.

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“…However, the benefits have been reported to differ among given species, in different clinical studies and by the IBS subtypes. [5][6][7][8][9][10][11][12][13][14][15][19][20][21][22][23] Some organisms exhibit immunomodulatory effects and limited abnormal fermentation in the colon. 24,25 Others have anti-inflammatory effects 26 or enhance the mucosal defense against luminal bacteria by preventing bacterial adherence to the epithelial cell surface, eliminating bacterial translocation and decreasing the increased intestinal permeability.…”

Section: Discussionmentioning

confidence: 99%

“…Lactobacilli, Bifidobacteria, and Streptococci are among the most commonly studied probiotics in IBS; they have demonstrated efficacy in patients with IBS. [5][6][7][8][9][10][11][12][13][14][15] However, the benefits of one given species or organism have not been shown to be better than other species or organisms. Dietary fiber is commonly used in the treatment of patients with IBS.…”

Section: Introductionmentioning

confidence: 99%

Probiotic Fermented Milk Containing Dietary Fiber Has Additive Effects in IBS with Constipation Compared to Plain Probiotic Fer-mented Milk

Choi

Kim²,

Rhee³

et al. 2011

Gut Liver

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Background/Aims: Although controversial, probiotics and dietary fiber are commonly used for patients with irritable bowel syndrome (IBS). We evaluated the effects of multistrain probiotics on the symptoms of IBS to determine whether the addition of dietary fi ber had an additive effect on constipation-predominant IBS. Methods: A total of 142 participants who met the Rome III criteria were recruited and randomized into a control group or a test group. Participants in the control group received multistrain probiotic fermented milk with Streptococcus thermophilus, Lactobacillus acidophilus and Bifi dobacterium infantis; the participants in the test group received the same probiotic fermented milk mixed with dietary fi ber such as sea tangle extracts, radish extracts and glasswort extracts. The patients were treated for four weeks. Results: Most of the symptoms of IBS, with the exception of fl atulence, stool consistency, and frequency of defecation, signifi cantly improved in both groups. In the analysis of IBS subtypes, especially constipation-predominant IBS, the frequency and duration of defecation and straining at stool were improved more in the test group than in the control group. Conclusions: Dietary fiber had additive benefits for the symptoms of constipation, especially in constipationpredominant IBS. (Gut Liver 2011;5:22-28)

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Single‐blind follow‐up study on the effectiveness of a symbiotic preparation in irritable bowel syndrome

Cited by 95 publications

References 41 publications

Probiotic Therapy of the Irritable Bowel Syndrome: Why Is the Evidence Still Poor and What Can Be Done About It?

Probiotic Therapy of the Irritable Bowel Syndrome: Why Is the Evidence Still Poor and What Can Be Done About It?

Probiotic use in irritable bowel syndrome

Probiotic Fermented Milk Containing Dietary Fiber Has Additive Effects in IBS with Constipation Compared to Plain Probiotic Fer-mented Milk

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