Single-atom nanozymes for biological applications

Pei, Jiahui; Zhao, Ruoli; Mu, Xiaoyu; Wang, Junying; Liu, Changlong; Zhang, Xiaodong

doi:10.1039/d0bm01447h

Cited by 70 publications

(39 citation statements)

References 154 publications

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“…Thanks to recent great achievements in the field of catalysis, single-atom catalysts (SACs), in which isolated metal atoms are located on the carrier, have been used in catalysis due to their high catalytic properties [ [33] , [34] , [35] , [36] ]. SACs have strong catalytic activity and can maximize metal utilization, which is especially important for cancer/antibacterial treatments to achieve effective disease treatment with relatively low metal concentrations [ [37] , [38] , [39] ].…”

Section: Introductionmentioning

confidence: 99%

Copper single-atom catalysts with photothermal performance and enhanced nanozyme activity for bacteria‐infected wound therapy

Wang

Shi

Zha

et al. 2021

Bioactive Materials

239

184

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Nanozymes have become a new generation of antibiotics with exciting broad-spectrum antibacterial properties and negligible biological toxicity. However, their inherent low catalytic activity limits their antibacterial properties. Herein, Cu single-atom sites/N doped porous carbon (Cu SASs/NPC) is successfully constructed for photothermal-catalytic antibacterial treatment by a pyrolysis-etching-adsorption-pyrolysis (PEAP) strategy. Cu SASs/NPC have stronger peroxidase-like catalytic activity, glutathione (GSH)-depleting function, and photothermal property compared with non-Cu-doped NPC, indicating that Cu doping significantly improves the catalytic performance of nanozymes. Cu SASs/NPC can effectively induce peroxidase-like activity in the presence of H 2 O 2 , thereby generating a large amount of hydroxyl radicals (•OH), which have a certain killing effect on bacteria and make bacteria more susceptible to temperature. The introduction of near-infrared (NIR) light can generate hyperthermia to fight bacteria, and enhance the peroxidase-like catalytic activity, thereby generating additional •OH to destroy bacteria. Interestingly, Cu SASs/NPC can act as GSH peroxidase (GSH-Px)-like nanozymes, which can deplete GSH in bacteria, thereby significantly improving the sterilization effect. PTT-catalytic synergistic antibacterial strategy produces almost 100% antibacterial efficiency against Escherichia coli ( E. coli ) and methicillin-resistant Staphylococcus aureus ( MRSA ). In vivo experiments show a better PTT-catalytic synergistic therapeutic performance on MRSA-infected mouse wounds. Overall, our work highlights the wide antibacterial and anti-infective bio-applications of Cu single-atom-containing catalysts.

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Section: Introductionmentioning

confidence: 99%

Copper single-atom catalysts with photothermal performance and enhanced nanozyme activity for bacteria‐infected wound therapy

Wang

Shi

Zha

et al. 2021

Bioactive Materials

239

184

View full text Add to dashboard Cite

show abstract

“…They are widely used in the treatment of cancer, inflammation elimination, antibacterial, neurological disease treatment, immunotherapy, etc [5d,91b,92] . In recent years, the SAzymes have figured prominently in the research process of nanozymes [67a,93] . SAzymes with high atomic utilization and a high degree of homogeneous dispersion of active sites bring about their unique and excellent performance in catalysis [10] .…”

Section: Biomedical Therapymentioning

confidence: 99%

Single‐Atom Nanozymes for Biomedical Applications: Recent Advances and Challenges

Tang

Cai

et al. 2022

Chemistry An Asian Journal

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Nanozymes have received extensive attention in the fields of sensing and detection, medical therapy, industry, and agriculture thanks to the combination of the catalytic properties of natural enzymes and the physicochemical properties of nanomaterials, coupled with superior stability and ease of preparation. Despite the promise of nanozymes, conventional nanozymes are constrained by their oversized size and low catalytic capacity in sophisticated practical application environments. single-atom nanozymes (SAzymes) were characterized as nanozymes with high catalytic efficiency by uniformly distributed single atoms as catalysis sites, thus effectively addressing the defects of conventional nanozymes. This paper reviews the activity improvement scheme and catalytic mechanism of SAzymes and highlights the latest research progress of SAzymes in the fields of biomedical sensing and therapy. Eventually, the challenges and future directions of SAzymes are discussed in this paper.

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“…As a result, single atom-based platforms have been developed for various kinds of enzymelike properties such as POD, SOD, CAT, OXD, etc. [109]. By using the enzyme mimetic properties of single atoms, Xu et al fabricated a zinc-based single atom supported by a metal organic framework and observed excellent POD-like properties [110].…”

Section: Figure 6 Schematic Representation Of Photothermal-enhanced Nanozymatic Mediated Cancer Therapy On Viruslikementioning

confidence: 99%

Peroxidase Mimetic Nanozymes in Cancer Phototherapy: Progress and Perspectives

Thangudu

2021

Biomolecules

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Nanomaterial-mediated cancer therapeutics is a fast developing field and has been utilized in potential clinical applications. However, most effective therapies, such as photodynamic therapy (PDT) and radio therapy (RT), are strongly oxygen-dependent, which hinders their practical applications. Later on, several strategies were developed to overcome tumor hypoxia, such as oxygen carrier nanomaterials and oxygen generated nanomaterials. Among these, oxygen species generation on nanozymes, especially catalase (CAT) mimetic nanozymes, convert endogenous hydrogen peroxide (H2O2) to oxygen (O2) and peroxidase (POD) mimetic nanozymes converts endogenous H2O2 to water (H2O) and reactive oxygen species (ROS) in a hypoxic tumor microenvironment is a fascinating approach. The present review provides a detailed examination of past, present and future perspectives of POD mimetic nanozymes for effective oxygen-dependent cancer phototherapeutics.

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Single-atom nanozymes for biological applications

Abstract: Nanozymes have been widely used as highly active and stable arterial enzyme due to controllable electronic transfer and the unique catalytic reaction route. However, the development of nanozymes are hindered...

Cited by 70 publications

References 154 publications

Copper single-atom catalysts with photothermal performance and enhanced nanozyme activity for bacteria‐infected wound therapy

Copper single-atom catalysts with photothermal performance and enhanced nanozyme activity for bacteria‐infected wound therapy

Single‐Atom Nanozymes for Biomedical Applications: Recent Advances and Challenges

Peroxidase Mimetic Nanozymes in Cancer Phototherapy: Progress and Perspectives

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