Single atom nanozymes for bacterial infection therapy

Lan, Xing; Chen, Miaomiao; He, Xin; Gao, Shutao; Zhao, Xinghua

doi:10.1039/d3bm01838e

Biomater. Sci.

2024

DOI: 10.1039/d3bm01838e

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Single atom nanozymes for bacterial infection therapy

Xing Lan,

Miaomiao Chen,

Xin He

et al.

Abstract: Bacterial infection-related diseases continue to pose a significant challenge to global human health. Single-atom nanozymes (SAzymes) have shown promissing potential as novel antibacterial agents for the future.

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2024

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Cited by 3 publications

References 60 publications

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Intratumoral Microbiota as a Target for Advanced Cancer Therapeutics

Peng,

Hu,

et al. 2024

Advanced Materials

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In recent years, advancements in microbial sequencing technology have sparked an increasing interest in the bacteria residing within solid tumors and its distribution and functions in various tumors. Intratumoral bacteria critically modulate tumor oncogenesis and development through DNA damage induction, chronic inflammation, epigenetic alterations, and metabolic and immune regulation, while also influencing cancer treatment efficacy by affecting drug metabolism. In response to these discoveries, a variety of anti‐cancer therapies targeting these microorganisms have emerged. These approaches encompass oncolytic therapy utilizing tumor‐associated bacteria, the design of biomaterials based on intratumoral bacteria, the use of intratumoral bacterial components for drug delivery systems, and comprehensive strategies aimed at the eradication of tumor‐promoting bacteria. Herein, this review article summarizes the distribution patterns of bacteria in different solid tumors, examines their impact on tumors, and evaluates current therapeutic strategies centered on tumor‐associated bacteria. Furthermore, the challenges and prospects for developing drugs that target these bacterial communities are also explored, promising new directions for cancer treatment.

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Intratumoral Microbiota as a Target for Advanced Cancer Therapeutics

Peng,

Hu,

et al. 2024

Advanced Materials

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Facile construction of Mo-based nanozyme system via ZIF-8 templating with enhanced catalytic efficiency and antibacterial performance

Jia,

Zheng,

et al. 2024

Heliyon

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A ruthenium single atom nanozyme-based antibiotic for the treatment of otitis media caused by Staphylococcus aureus

Wang,

Gong,

Yang

et al. 2024

Front. Chem.

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Staphylococcus aureus (S. aureus) infection is a primary cause of otitis media (OM), the most common disease for which children are prescribed antibiotics. However, the abuse of antibiotics has led to a global increase in antimicrobial resistance (AMR). Nanozymes, as promising alternatives to traditional antibiotics, are being extensively utilized to combat AMR. Here, we synthesize a series of single-atom nanozymes (metal-C3N4 SANzymes) by loading four metals (Ag, Fe, Cu, Ru) with antibacterial properties onto a crystalline g-C3N4. These metal-C3N4 display a rob-like morphology and well-dispersed metal atoms. Among them, Ru-C3N4 demonstrates the optimal peroxidase-like activity (285.3 U mg–1), comparable to that of horseradish peroxidase (267.7 U mg–1). In vitro antibacterial assays reveal that Ru-C3N4 significantly inhibits S. aureus growth compared with other metal-C3N4 even at a low concentration (0.06 mg mL–1). Notably, Ru-C3N4 acts as a narrow-spectrum nanoantibiotic with relative specificity against Gram-positive bacteria. Biofilms formed by S. aureus are easily degraded by Ru-C3N4 due to its high peroxidase-like activity. In vivo, Ru-C3N4 effectively eliminates S. aureus and relieves ear inflammation in OM mouse models. However, untreated OM mice eventually develop hearing impairment. Due to its low metal load, Ru-C3N4 does not exhibit significant toxicity to blood, liver, or kidney. In conclusion, this study presents a novel SANzyme-based antibiotic that can effectively eliminate S. aureus and treat S. aureus-induced OM.

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Single atom nanozymes for bacterial infection therapy

Abstract: Bacterial infection-related diseases continue to pose a significant challenge to global human health. Single-atom nanozymes (SAzymes) have shown promissing potential as novel antibacterial agents for the future.

Cited by 3 publications

References 60 publications

Intratumoral Microbiota as a Target for Advanced Cancer Therapeutics

Intratumoral Microbiota as a Target for Advanced Cancer Therapeutics

Facile construction of Mo-based nanozyme system via ZIF-8 templating with enhanced catalytic efficiency and antibacterial performance

A ruthenium single atom nanozyme-based antibiotic for the treatment of otitis media caused by Staphylococcus aureus

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