Single-atom materials for food safety

Luo, Xin; Zhao, Jinsong; Li, Min; Zhao, Xiao; Wei, Xiaoqian; Luo, Zhen; Gu, Wenling; Du, Dan; Lin, Yuehe; Zhu, Chengzhou

doi:10.1016/j.mattod.2023.02.010

Cited by 18 publications

(13 citation statements)

References 140 publications

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“…This causes large model behavior changes for multi-step sampling which reduces compatibility with LoRA modules and plugins. This method has been applied to SDXL [36,37] but its generation quality is poor under 8 steps. Consistency Trajectory Model (CTM) [22] adds adversarial loss and supports jumping to arbitrary flow locations, but the adversarial training is applied post-distillation, instead of during the distillation, and the method has not been applied to large-scale text-to-image models.…”

Section: Other Distillation Methodsmentioning

confidence: 99%

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Discovering Novel Antimicrobial Peptides in Generative Adversarial Network

Lin

Yang

Wang

et al. 2021

Preprint

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Due to the growing number of clinical antibiotic resistance cases in recent years, novel antimicrobial peptides (AMPs) can become ideal for next-generation antibiotics. This study trained a deep convolutional generative adversarial network (GAN) with known AMPs to generate novel AMP candidates. The quality of the GAN-designed peptides was evaluated in silico, and eight of them named GAN-pep 1∼8 were chosen to be synthesized for further experiments. Disk diffusion testing and minimum inhibitory concentration (MIC) determination were used to determine the antibacterial effects of the synthesized GAN-designed peptides. Seven out of the eight synthesized GAN-designed peptides showed antibacterial activities.Additionally, GAN-pep 3 and GAN-pep 8 had a broad spectrum of antibacterial effects. Both of them were also effective against antibiotic-resistant bacteria strains such as methicillin-resistant Staphylococcus aureus (S. aureus) and carbapenem-resistant Pseudomonas aeruginosa (P. aeruginosa). GAN-pep 3, the most promising GAN-designed peptide candidate, had low MICs against all the tested bacteria.

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Section: Other Distillation Methodsmentioning

confidence: 99%

“…LCM-LoRA [37] is the first to show that model distillation can also be trained as a LoRA module. This ensures minimum parameter changes and can be conveniently plugged into the existing ecosystem.…”

Section: Loramentioning

confidence: 99%

Discovering Novel Antimicrobial Peptides in Generative Adversarial Network

Lin

Yang

Wang

et al. 2021

Preprint

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“…(4) Combining SAzymes with various cutting-edge technologies, such as electrochemistry, enzyme-linked immunoassay, lateral flow immunoassay, colorimetric assay, fluorescence assay, etc., could make full use of the advantages of SAzymes and thus actually broaden the applicability mode of SAzymes in food testing. (5) To accelerate the application of SAzymes in rapid and on-site food testing, researchers should pay more attention to combining food testing with smart phones and modern intelligent machine learning, obtaining rapid and sensitive detection without equipment; this would enable the tracking of results in real time and realize the goal of normalizing and developing food testing. − At present, the application of SAzymes in food analysis still has a large development space, and we expect that this review will provide some inspiration and ideas for the further application of SAzymes in food detection.…”

Section: Summary and Perspectivesmentioning

confidence: 99%

Perspectives for the Role of Single-Atom Nanozymes in Assisting Food Safety Inspection and Food Nutrition Evaluation

Wu,

Xia,

et al. 2024

Anal. Chem.

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Single-atom nanozymes (SAzymes) have been greatly developed for rapid detection, owing to their rich active sites and excellent catalytic activity. Although several excellent reviews concentrating on SAzymes have been reported, they mainly focused on advanced synthesis, sensing mechanisms, and biomedical applications. To date, few reviews elaborate on the promising applications of SAzymes in food safety inspection and food nutrition evaluation. In this paper, we systematically reviewed the enzyme-like activity of SAzymes and the catalytic mechanism, in addition to recent research advances of SAzymes in the domain of food safety inspection and food nutrition evaluation in the past few years. Furthermore, current challenges hampering practical applications of SAzymes in food assay are summarized and analyzed, and possible research areas focusing on SAzyme-based sensors in rapid food testing are also proposed.

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“…Single-atom catalysts (SACs) have become the most popular research frontiers of heterocatalysis owing to their maximum metal utilization and outstanding catalytic activity. − Well-defined and atomically dispersed metal active sites of SACs open up avenues for deeply understanding the relationship between catalytic performance and structure at the atomic scale compared with the conventional bulk nanoparticles. − Noteworthily, it is found that metal–nitrogen–carbon (M–N–C) SACs are capable of adsorbing and activating PDS to produce strong oxidative species such as SO 4 •– via a radical-mediated mechanism, which can be employed to degrade pollutants in water. − Therefore, it is hypothesized that an enhanced Ru(bpy) 3 2+ –PDS ECL system could be constructed using M–N–C SACs as efficient co-reaction accelerators to promote the activation efficiency of PDS. As far as we know, in comparison with numerous studies in electrocatalysis and biocatalysis, SACs have rarely been applied to Ru(bpy) 3 2+ ECL systems, and their mechanisms are unknown.…”

Section: Introductionmentioning

confidence: 99%

Iron Single-Atom Catalyst-Enabled Peroxydisulfate Activation Enhances Cathodic Electrochemiluminescence of Tris(bipyridine)ruthenium(II)

Luo

et al. 2023

Anal. Chem.

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The tris(bipyridine)ruthenium(II) (Ru(bpy) 3 2+ )−tripropylamine anodic electrochemiluminescence (ECL) system has been widely applied in commercial bioanalysis. However, the presence of amine compounds in the biological environment results in unavoidable anodic interference signals, which hinder further extensive use of the system. In contrast, the cathodic Ru(bpy) 32+ ECL system can overcome these limitations. The Ru(bpy) 3 2+ /peroxydisulfate (S 2 O 8 2−, PDS) ECL system has been extensively employed due to its ability to produce a sulfate radical anion (SO 4•− ) with strong oxidation ability, which enhances the ECL signal. However, the symmetrical molecular structure of PDS makes it challenging to be activated and causes low luminescence efficiency. To address this issue, we propose an efficient Ru(bpy) 3 2+ -based ternary ECL system that uses the iron−nitrogen−carbon single-atom catalyst (Fe−N−C SAC) as an advanced accelerator. Fe−N−C SAC can efficiently activate PDS into reactive oxygen species at a lower voltage, which significantly boosts the cathodic ECL emission of Ru(bpy) 3 2+ . Benefiting from the outstanding catalytic activity of Fe−N−C SAC, we successfully established an ECL biosensor that detects alkaline phosphatase activity with high sensitivity, demonstrating the feasibility of practical application.

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Single-atom materials for food safety

Cited by 18 publications

References 140 publications

Discovering Novel Antimicrobial Peptides in Generative Adversarial Network

Discovering Novel Antimicrobial Peptides in Generative Adversarial Network

Perspectives for the Role of Single-Atom Nanozymes in Assisting Food Safety Inspection and Food Nutrition Evaluation

Iron Single-Atom Catalyst-Enabled Peroxydisulfate Activation Enhances Cathodic Electrochemiluminescence of Tris(bipyridine)ruthenium(II)

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