Single-arm open-label study of Durolane (NASHA nonanimal hyaluronic acid) for the treatment of osteoarthritis of the thumb

Abstract

IntroductionOsteoarthritis of the trapeziometacarpal (TMC) joint of the thumb – also known as rhizarthrosis – is painful and has a significant impact on quality of life. Intra-articular injection of hyaluronic acid may potentially meet the need for effective, minimally invasive intervention in patients not responding adequately to initial treatment. We aimed to confirm the safety and effectiveness of viscosupplementation with Durolane (NASHA nonanimal hyaluronic acid) in rhizarthrosis.Patients and methodsThis was a prospective, single-arm, multicenter, open-label study with a 6-month follow-up period. Eligible patients had Eaton–Littler grade II–III rhizarthrosis in one TMC joint with pain and visual analog scale (VAS) pain score ≥4 (scale: 0–10). A single injection of NASHA was administered to the affected TMC joint. The primary effectiveness variable was change from baseline in VAS pain score.ResultsThirty-five patients (mean age 60.8 years; 85.7% female) received NASHA and completed the study. The least-squares mean change from baseline in VAS pain score over 6 months was −2.00, a reduction of 27.8% (p<0.001). The reduction in pain exceeded 25% as early as month 1 (26.5%), and gradual improvement was observed throughout the 6-month follow-up period. Secondary effectiveness parameters included QuickDASH (shortened version of Disabilities of the Arm, Shoulder, and Hand [DASH]), Kapandji thumb opposition test, radial abduction, metacarpophalangeal (MCP) joint flexion, and pinch (clamp) strength. Most of these measurements showed statistically significant improvements from baseline over 6 months. Five adverse events (injection site reactions) were reported in four patients (11.4%), and there were no serious or allergic reactions.ConclusionThis study suggests that viscosupplementation using NASHA is effective and well tolerated in treating the symptoms of rhizarthrosis.

Glycosaminoglycan and Proteoglycan Biotherapeutics in Articular Cartilage Protection and Repair Strategies: Novel Approaches to Visco‐supplementation in Orthobiologics

“…Biomedical B Baumann Group [242] 10 × 10 12 Da NASHA HAs Durolane Bioventus (USA) [243,257,268,269] functionalities which are reactive with bi-functional reagents and these can be used to attach peptides to the CS backbone. AFM confirmed that the attached peptides adopted a bristle-like distribution in a bottle-brush type arrangement on the CS core and they thus explored all available spatial orientations which would be expected to optimize the space-filling and interactive properties of the peptidoglycans.…”

Surface EMG data aggregation processing for intelligent prosthetic action recognition

“…In this paper, because the research is mainly about the basic movements of the hand, we choose the forearm which is closer to the hand distance to extract the signal. In practice, the fingers of the hand can be divided into three parts according to the motion correlation degree, that is, the distribution of the thumb and the index finger as a single motion part and the other three fingers together to form a motion part; Kapandji test ,which is a widely used evaluation criterion for the dexterity of the prostheses in the world [20][21][22]. The core of the standard is whether the thumb of the bionic hand can touch the fingertips and of the other four fingers conveniently.…”

“…The support vector machine is mainly used for multi classification, the kernel function type is RBF (radial basis) kernel function, the kernel function parameter is 3.05176*10-5, the total number of classes is 9, the whole SVM model support vector number is 278, the support vector of each category is numbered. Instead of 37,32,14,21,26,37,30,42 and 39, the model will list all the support vectors.…”

The prevalence and burden of hand and wrist bleeds in von Willebrand disease

“…Musculoskeletal hand problems, like osteoarthritis, can cause pain, significant impairment of daily activities and reduced satisfaction with hand appearance . Future research on the consequences of hand bleeds should be performed.…”