Single and Repeated Environmental Stress: Effect on Plasma Oxytocin, Corticosterone, Catecholamines, and Behavior

Hashiguchi, Hiroyuki; Ye, Shao Hua; Morris, Mariana; Alexander, Natalie

doi:10.1016/s0031-9384(96)00527-6

Cited by 66 publications

(52 citation statements)

References 16 publications

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“…Finally, besides the OT-induced decrease in IM, this peptide may stimulate circuitries with anxyolitic actions, as already demonstrated for CeA OT application, in the open field and the elevated plus maze. 8,60 Stressful situations, such as environmental stress (shaker stress) and forced swimming, increase OT plasma levels 61,62 probably acting as a counter mechanism of the anxiogenic situation. Grooming behaviors are mainly induced in anxiogenic and conflict situations.…”

Section: Discussionmentioning

confidence: 99%

Neuroanatomical and cellular substrates of hypergrooming induced by microinjection of oxytocin in central nucleus of amygdala, an experimental model of compulsive behavior

et al. 2007

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Oxytocin (OT) is a neurosecretory nonapeptide synthesized in hypothalamic cells that project to the neurohypophysis as well as to widely distributed sites in the central nervous system. Central OT microinjections induce a variety of cognitive, sexual, reproductive, grooming and affiliative behaviors in animals. Obsessive-compulsive disorder (OCD) includes a range of cognitive and behavioral symptoms that bear some relationship with OT. Here, we study the neuroanatomical and cellular substrates of the hypergrooming induced by administration of OT in the central nucleus of amygdala (CeA). In this context, this hypergrooming is considered as a model of compulsive behavior. Our data suggest a link between the CeA and the hypothalamic grooming area (HGA). The HGA includes parts of the paraventricular nucleus and the dorsal hypothalamic area. Our data on colocalization of OT (immunohistochemistry for peptide), OT receptor (binding assay) and its retrogradely labeled cells after Fluoro-Gold injection in the CeA suggest that CeA and connections are important substrates of the circuit underlying this OT-dependent compulsive behavioral pattern.

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Section: Discussionmentioning

confidence: 99%

Neuroanatomical and cellular substrates of hypergrooming induced by microinjection of oxytocin in central nucleus of amygdala, an experimental model of compulsive behavior

et al. 2007

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“…However, in contrast to our results, a study in rats showed no attenuation of the corticosterone response to repeated shaker stress. 13 The difference in the results may be related to the level of stimulation and/or the animal species. Hashiguchi et al 13 tested the effect of daily shaking sessions delivered over 14 days, whereas in our experiment, mice were exposed to 315 shaking sessions over a 7-day period.…”

Section: Discussionmentioning

confidence: 99%

“…13 The difference in the results may be related to the level of stimulation and/or the animal species. Hashiguchi et al 13 tested the effect of daily shaking sessions delivered over 14 days, whereas in our experiment, mice were exposed to 315 shaking sessions over a 7-day period. Taking into consideration the number of stress sessions administered and the time course of the plasma corticosterone response, it is likely that there is a generalized increase in adrenal steroid secretion in the chronically stressed mice.…”

Section: Discussionmentioning

confidence: 99%

“…4,8,11 Shaker stress is a mild, pain-free stimulus that elicits reproducible changes in BP, HR, sympathetic activity, and stress hormone secretion. 12,13 There is no information on the application of shaker stress in mice and no data on the long-term effects of shaker stress on the cardiovascular system or on drinking and eating patterns.For investigations in mice, we developed a computerized system for chronic, continuous BP recording and combined this with electronic recording of licking activity for analysis of circadian patterns. 14,15 This methodology was applied to the investigation of the effects of stress on BP and HR responses and drinking behavior during the active (dark period) and nonactive (light period) phases in normotensive mice.…”

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Circadian Differences in Stress-Induced Pressor Reactivity in Mice

Bernátová

Key²,

Lucot³

et al. 2002

Hypertension

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Abstract-The objective of this study was to determine the effect of chronic stress exposure on the circadian pattern of cardiovascular responses in mice. Using male C57BL6 mice with carotid arterial catheters, we tested the effect of 7 days of intermittent shaker stress on body weight, food intake, drinking activity, plasma corticosterone, mean arterial pressure (MAP), and heart rate. The stress was delivered automatically for 2-minute periods (150 cycles/min), 45 times/d for 7 days. Plasma corticosterone was significantly increased in acutely and chronically stressed mice, with a partial attenuation in the chronic condition. Stress increased water intake, produced no change in food intake, and significantly decreased body weight (5% change). MAP and heart rate were measured continuously on stress days 1, 3, and 7 and during the basal and recovery periods. Chronic stress did not produce a sustained increase in MAP; however, there was an increase in MAP during the first stress day and a decrease during the recovery period. There was a circadian pattern in the pressor responses, with greater increases seen during the light period (nonactive phase) than in the dark period (ϩ24% versus ϩ11% on stress day 3, light versus dark). The results suggest that a stress delivered during the nonactive phase represents a higher cardiovascular risk. Key Words: blood pressure Ⅲ heart rate Ⅲ corticosterone Ⅲ circadian rhythm L ifestyle stress is a risk factor for human diseases, including cancer, stroke, psychological disorders, and heart disease. There is a circadian pattern in the incidence of cardiovascular pathologies, with a higher frequency of heart attacks, strokes, and arrhythmias during the morning hours. [1][2][3] Stressful conditions may also be a precipitating factor in the occurrence of cardiovascular accidents.In animals, stress exposure produced by a variety of methods provokes a cascade of autonomic adjustments characterized by increased blood pressure (BP), increased heart rate (HR), and behavioral alterations. Most studies of stress biology have been conducted in rats, providing information on changes in cardiovascular function and eating and drinking behaviors. 4 -10 However, one complication of the experimental paradigms is that the stress effects can be enhanced by animal handling, noise, or pain, as seen in the forced swim test, air jet exposure, and physical restraint. 4,8,11 Shaker stress is a mild, pain-free stimulus that elicits reproducible changes in BP, HR, sympathetic activity, and stress hormone secretion. 12,13 There is no information on the application of shaker stress in mice and no data on the long-term effects of shaker stress on the cardiovascular system or on drinking and eating patterns.For investigations in mice, we developed a computerized system for chronic, continuous BP recording and combined this with electronic recording of licking activity for analysis of circadian patterns. 14,15 This methodology was applied to the investigation of the effects of stress on BP and HR responses and dri...

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Distribution of preproadrenomedullin mRNA in the rat central nervous system and its modulation by physiological stressors

Shan

Krukoff

2001

J of Comparative Neurology

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Adrenomedullin (ADM), encoded by the preproadrenomedullin (ppADM) gene, exerts multiple effects in a wide variety of peripheral and central tissues. Although ADM-like immunoreactivity has been shown to be widely distributed throughout the rat central nervous system (CNS), the detailed distribution of ppADM gene expression in the CNS and its modulation by physiological stimuli remain unknown. In our study, in situ hybridization was used to localize ppADM mRNA in the rat brain and to quantify its levels after exposure to different stressors including lipopolysaccharide (LPS; 100 microg/kg, iv), restraint stress (2 cycles of 1 hour restraint/1 hour rest), and 24 hours of dehydration. In addition, Fos immunoreactivity was used to identify the activation of neurons in response to LPS. Our results show that ppADM mRNA is widely distributed throughout the rat CNS, with especially high levels in autonomic centers including the hypothalamic paraventricular nucleus (PVN), hypothalamic supraoptic nucleus (SON), locus coeruleus, ventrolateral medulla, and intermediolateral cell column of the spinal cord. Furthermore, LPS inhibits ppADM gene expression in the parvocellular PVN (pPVN), magnocellular PVN (mPVN), SON, dorsal motor nucleus of the vagus, and area postrema among examined regions; restraint stress reduces ppADM mRNA levels in the pPVN, mPVN, SON, nucleus of the solitary tract, dorsal motor nucleus of the vagus, area postrema, and subfornical organ; 24 hours of water deprivation decreases ppADM gene expression only in the mPVN and SON. Taken together, our results suggest that ADM is involved in the regulation of the hypothalamo-neurohypophysial system, the hypothalamo-pituitary-adrenal axis, and central autonomic functions.

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Single and Repeated Environmental Stress: Effect on Plasma Oxytocin, Corticosterone, Catecholamines, and Behavior

Cited by 66 publications

References 16 publications

Neuroanatomical and cellular substrates of hypergrooming induced by microinjection of oxytocin in central nucleus of amygdala, an experimental model of compulsive behavior

Neuroanatomical and cellular substrates of hypergrooming induced by microinjection of oxytocin in central nucleus of amygdala, an experimental model of compulsive behavior

Circadian Differences in Stress-Induced Pressor Reactivity in Mice

Distribution of preproadrenomedullin mRNA in the rat central nervous system and its modulation by physiological stressors

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