Single and multiple food allergies in infants with proctocolitis

Köksal, Burcu Tahire; Barış, Zeren; Özçay, Figen; Özbek, Özlem

doi:10.1016/j.aller.2017.02.006

Cited by 15 publications

(22 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We found the frequency of multiple food allergies to be 24.1%; egg, nuts, and meat were the most common accompanying culprit foods in our group. In accordance with our results, Koksal et al (20) observed that most of the patients who developed tolerance after 2 years of age had multiple food allergies.…”

Section: Discussionsupporting

confidence: 94%

“…Hence, physicians should take into account dietary habits in their geographic region when eliminating foods, particularly, in patients who do not respond to removal of cow's milk. Lucarelli et al (19) reported multiple food allergies as 5%, whereas this rate was as high as 34% in another study by Koksal et al (20). We found the frequency of multiple food allergies to be 24.1%; egg, nuts, and meat were the most common accompanying culprit foods in our group.…”

Section: Discussionmentioning

confidence: 94%

See 1 more Smart Citation

Risk Factors Influencing Tolerance and Clinical Features of Food Protein–induced Allergic Proctocolitis

Büyüktiryaki¹,

Celik²,

Erdem

et al. 2020

J. pediatr. gastroenterol. nutr.

View full text Add to dashboard Cite

Objective: Continued progress in our understanding of the food protein–induced allergic proctocolitis (FPIAP) will provide the development of diagnostic tests and treatments. We aimed to identify precisely the clinical features and natural course of the disease in a large group of patients. Also, we investigated the predicting risk factors for persistent course since influencing parameters has not yet been established. Methods: Infants who were admitted with rectal bleeding and had a diagnosis of food protein–induced allergic proctocolitis in 5 different allergy or gastroenterology outpatient clinics were enrolled. Clinical features, laboratory tests, and prognosis were evaluated. Risk factors for persistent course were determined by logistic regression analyses. Results: Among the 257 infants, 50.2% (n = 129) were girls and cow's milk (99.2%) was the most common trigger. Twenty-four percent of the patients had multiple food allergies and had more common antibiotic use (41.9% vs 11.8%), atopic dermatitis (21% vs 10.2%), wheezing (11.3% vs 1.5%), colic (33.8% vs 11.2%), and IgE sensitization (50% vs 13.5%) compared to the single-food allergic group (P < 0.001, P = 0.025, P = 0.003, P < 0.001, respectively). In multivariate logistic regression analysis, presence of colic (odds ratio [OR]: 5.128, 95% confidence interval [CI]: 1.926–13.655, P = 0.001), IgE sensitization (OR: 3.964, 95% CI: 1.424–11.034, P = 0.008), and having allergy to multiple foods (OR: 3.679, 95% CI: 1.278–10.593, P = 0.001] were found to be risk factors for continuing disease after 1 year of age. Conclusion: Although most children achieve tolerance at 1 year of age, IgE sensitization, allergy to multiple foods, and presence of colic were risk factors for persistent course and late tolerance. In this context, these children may require more close and extended follow-up.

show abstract

Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 94%

Risk Factors Influencing Tolerance and Clinical Features of Food Protein–induced Allergic Proctocolitis

Büyüktiryaki¹,

Celik²,

Erdem

et al. 2020

J. pediatr. gastroenterol. nutr.

View full text Add to dashboard Cite

show abstract

“…The most common triggering foods in both groups of infants in our study, and with no difference between groups, were cow’s milk and egg. Koksal and colleagues found that infants with FPIAP developed tolerance to egg later than those achieving tolerance to milk [ 34 ]. Avoidance of dairy foods in the mothers’ diet did not influence the acquisition of overall tolerance, while the elimination of more foods appears to be associated with a later development of tolerance.…”

Section: Discussionmentioning

confidence: 99%

Dietary Factors May Delay Tolerance Acquisition in Food Protein-Induced Allergic Proctocolitis

et al. 2023

View full text Add to dashboard Cite

Background: Dietary and environmental factors may influence tolerance acquisition in food protein-induced allergic proctocolitis (FPIAP). This retrospective observational study explored the role of maternal diet during pregnancy and breastfeeding in tolerance acquisition in infantile FPIAP. Methods: Breastfed infants with FPIAP from six diverse regions in Greece were divided into two groups, based on development of tolerance to the trigger food: Group A (n = 43), before, and Group B (n = 53), after, the 6th month of age. Maternal diet during pregnancy and breastfeeding was elicited using the Mediterranean Diet Score Questionnaire and the Mediterranean Oriented Culture Specific Semi-Quantitative Food Frequency Questionnaire. Results: Mean age at diagnosis of FPIAP (1.5 months) and weaning (5.5 months) were the same in both groups. The main trigger was cow’s milk. Group A received infant milk formula earlier than Group B. Group B had a higher incidence of asthma/wheeze, siblings with milk allergy, maternal smoking and rural residence. On multivariate analysis, earlier resolution of FPIAP was associated with higher maternal education and with salt intake and consumption of goat/sheep cheese during pregnancy and olive oil during breastfeeding. Consumption of multivitamins during pregnancy and meat, winter fruits, green vegetables, butter, salt, “ready-to-eat” meals and pastries during breastfeeding were correlated with longer duration of symptoms. Conclusions: Mothers of children with FPIAP to cow’s milk protein can be advised to eat more yogurt, cheese and olive oil during subsequent pregnancies, and avoid multivitamins, grilled food, “ready-to-eat” meals, pastries, meat and alcohol during breastfeeding, to reduce the duration of FPIAP presenting in future infants.

show abstract

“…FPIES was associated with eosinophilic inflammation in histology of colonic biopsy in some cases (14). Infants with multiple food allergies have a high blood total eosinophil count (15). It is known that eosinophils can release cytokines and chemokines, that modulate inflammatory responses and may also affect tissue remodelling and fibrosis by releasing transforming growth factors (16).…”

Section: Discussionmentioning

confidence: 99%

Food protein-induced enterocolitis syndrome presenting after necrotizing enterocolitis in a preterm neonate: a case report

Lü

Zhiqun

2021

Transl Pediatr

View full text Add to dashboard Cite

is inflammation of the intestine leading to bacterial invasion causing necrosis of the colon and the intestine (2). As NEC progresses, it can lead to intestinal perforation causing peritonitis, sepsis, and even death. In the clinical setting, approximately half of all infants with NEC respond to bowel rest, antibiotics, and supportive medical measures, but others develop progressive bowel disease and require surgical

show abstract

Single and multiple food allergies in infants with proctocolitis

Abstract: There is no difference in clinical presentations between infants with single and multiple food allergies. However, infants with multiple food allergies have a high blood total eosinophil count and are more likely to have a positive skin prick test and/or positive specific IgE results.

Cited by 15 publications

References 28 publications

Risk Factors Influencing Tolerance and Clinical Features of Food Protein–induced Allergic Proctocolitis

Risk Factors Influencing Tolerance and Clinical Features of Food Protein–induced Allergic Proctocolitis

Dietary Factors May Delay Tolerance Acquisition in Food Protein-Induced Allergic Proctocolitis

Food protein-induced enterocolitis syndrome presenting after necrotizing enterocolitis in a preterm neonate: a case report

Contact Info

Product

Resources

About