Single and combined genotoxic and cytotoxic effects of two xenobiotics widely used in intensive aquaculture

Jerbi, M.A.; Ouanes, Zouhour; Besbes, Raouf; Achour, Lotfi; Kacem, Adnane

doi:10.1016/j.mrgentox.2011.04.010

Cited by 33 publications

(17 citation statements)

References 64 publications

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“…Decreasing trend of marine catch has lead to simultaneous intensification of aquaculture techniques, resulting more susceptibility to disease outbreaks and ultimately it triggers the use of the medication and medicated diet (Jerbi et al, 2011). Now, aquaculture is the major protein supplier all over the world.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Oxytetracycline on Thai Silver Barb (Barbonymus gonionotus) and on it’s Culture Environment

Islam¹,

Rasul²,

Kashem³

et al. 2015

J. of Fisheries and Aquatic Science

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Studies were conducted to investigate impacts of oxytetracycline on Barbonymus gonionotus muscle. Oxytetracycline the most widely used antibiotics, was fed to Barbonymus gonionotus with 4 g kgG 1 rate through diet for 45 days. Growth rate was observed for different concentrations of oxytetracycline. Water quality parameters and bacterial quantification were observed for a period of 21 days. Pond water, sediment and fish muscle were tested before and after oxytetracycline medicated feeding. Before feeding of oxytetracycline medicated feed, there was no oxytetracycline in water, sediment and fish muscles. After 2 days of feeding the initial oxytetracycline accumulation was 5070.0 ppb, which reduced considerably to 1190.0 ppb after 20 days from end of medicated diet feeding and not detected after 42 days. Physico-chemical parameters of pond water were determined. Before treatment dissolve oxygen, pH and total hardness of fish pond was 4.516±0.25 mg LG 1 , 7.413±0.09 and 822.33±1.52 ppm, respectively. After 21 days of study period, reached to 5.27±0.025 mg LG 1

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Section: Introductionmentioning

confidence: 99%

“…Oxytetracycline is a tetracycline broad spectrum antibiotic with bacteriostatic action produced by Streptomyces spp. fungi, used to treat systemic bacterial infections of fish (Jerbi et al, 2011). Oxytetracycline is more active against some bacteria than chloramphenicol (Burridge et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Effect of Oxytetracycline on Thai Silver Barb (Barbonymus gonionotus) and on it’s Culture Environment

Islam¹,

Rasul²,

Kashem³

et al. 2015

J. of Fisheries and Aquatic Science

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“…Because MN is usually given off along with the main nucleus, their presence would suggest their origin at a cell cycle that is more recent (Chandra and Khuda-Bukhsh, 2004). According to Jerbi et al, (2011), the formation of micronucleated cells may be an indication of aneugenic and/or clastogenic actions, because the presence of MN can be related to entire chromosomes, caused by a malfunctioning of the spindle, or with chromosome fragments, derived from chromosome breakage.…”

Section: Discussionmentioning

confidence: 99%

Cytotoxic and genotoxic effects of perfluorododecanoic acid (PFDoA) in Japanese medaka

Ayanda

Yang

Zhang

et al. 2018

Knowl. Manag. Aquat. Ecosyst.

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-This study investigated the cytotoxic and genotoxic potential of perfluorododecanoic acid (PFDoA), a perfluorinated carboxylic chemical (PFC) that has broad applications and distribution in the environment in Japanese medaka, Oryzias latipes. Micronucleus (MN) test and Comet assay were used for the toxicity study. Three groups of fish were exposed to 0.1 mg/L, 0.5 mg/L and 2.5 mg/L concentration of the chemical for 28 days. Another group served as control. Sampling of the fish blood and liver were done after days 1, 4, 7, 14, 21 and 28 for analysis of different erythrocyte abnormalities and damage to DNA using the MN test and Comet assay respectively. Results showed that there was a significant time and concentration dependent increase (p < 0.05) in percent tail length of DNA and frequency of erythrocyte abnormalities. Nuclear abnormalities observed include micronucleus, fragmented apoptotic cells, lobed nuclei, and bean-shaped cells. Increase in induction of erythrocyte abnormalities and percent tail length of DNA peaked at days 14 and 7, respectively, after which there was a gradual decline. The results indicate that sub-chronic exposure of PFDoA to Japanese medaka caused DNA damage with a simultaneous induction of different erythrocyte abnormalities.

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“…In addition to environmental concerns over organic enrichment and the depletion of dissolved oxygen stemming from the discharge of suspended solid wastes, the potential toxic effects of chemicals used to control and treat disease outbreaks must also be considered47. The potential enrichment of functional pathways for xenobiotics degradation and metabolism in the aerobic sediment system demonstrates a potential to bioremediate a variety of chemical therapeutants used in intensive aquaculture, including antibiotics, anaesthetics and anti-parasitic agents.…”

Section: Discussionmentioning

confidence: 99%

Profiling bacterial communities associated with sediment-based aquaculture bioremediation systems under contrasting redox regimes

Robinson

Caldwell

Wade

et al. 2016

Sci Rep

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Deposit-feeding invertebrates are proposed bioremediators in microbial-driven sediment-based aquaculture effluent treatment systems. We elucidate the role of the sediment reduction-oxidation (redox) regime in structuring benthic bacterial communities, having direct implications for bioremediation potential and deposit-feeder nutrition. The sea cucumber Holothuria scabra was cultured on sediments under contrasting redox regimes; fully oxygenated (oxic) and redox stratified (oxic-anoxic). Taxonomically, metabolically and functionally distinct bacterial communities developed between the redox treatments with the oxic treatment supporting the greater diversity; redox regime and dissolved oxygen levels were the main environmental drivers. Oxic sediments were colonised by nitrifying bacteria with the potential to remediate nitrogenous wastes. Percolation of oxygenated water prevented the proliferation of anaerobic sulphate-reducing bacteria, which were prevalent in the oxic-anoxic sediments. At the predictive functional level, bacteria within the oxic treatment were enriched with genes associated with xenobiotics metabolism. Oxic sediments showed the greater bioremediation potential; however, the oxic-anoxic sediments supported a greater sea cucumber biomass. Overall, the results indicate that bacterial communities present in fully oxic sediments may enhance the metabolic capacity and bioremediation potential of deposit-feeder microbial systems. This study highlights the benefits of incorporating deposit-feeding invertebrates into effluent treatment systems, particularly when the sediment is oxygenated.

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Single and combined genotoxic and cytotoxic effects of two xenobiotics widely used in intensive aquaculture

Cited by 33 publications

References 64 publications

Effect of Oxytetracycline on Thai Silver Barb (Barbonymus gonionotus) and on it’s Culture Environment

Effect of Oxytetracycline on Thai Silver Barb (Barbonymus gonionotus) and on it’s Culture Environment

Cytotoxic and genotoxic effects of perfluorododecanoic acid (PFDoA) in Japanese medaka

Profiling bacterial communities associated with sediment-based aquaculture bioremediation systems under contrasting redox regimes

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