Single and combined effects of Δ⁹‐tetrahydrocannabinol and cannabidiol in a mouse model of chemotherapy‐induced neuropathic pain

Abstract

CBD may be potent and effective at preventing the development of chemotherapy-induced peripheral neuropathy, and its clinical use may be enhanced by co-administration of low doses of THC. These treatment strategies would increase the therapeutic window of cannabis-based pharmacotherapies.

Single and combined effects of plant‐derived and synthetic cannabinoids on cognition and cannabinoid‐associated withdrawal signs in mice

“…Therefore, it is also critical to determine the efficacy of CBD alone compared with THC and the CBD + THC combination, to determine optimal cannabinoid‐based treatment strategies for the future. Recently, we have demonstrated, for example, that while both CBD and THC alone prevent development of mechanical sensitivity in a mouse model of chemotherapy‐induced peripheral neuropathic pain, a 1:1 ratio of CBD to THC acted synergistically, leading to an approximate 10‐fold increase in potency in the model (King et al, ). Thus, CBD as a monotherapy may represent a safe and effective treatment strategy for neuropathic pain, while co‐administration of equivalent THC + CBD doses may lead to lower doses of each agent being necessary, thereby attaining the goal of decreasing THC‐associated adverse effects.…”

“…For example, CBD may either synergize with or antagonize THC effects to enhance wanted actions and/or antagonize adverse actions (Russo, ). We have recently demonstrated, for example, that a 1:1 ratio of CBD to THC synergistically prevented development of mechanical sensitivity in a mouse model of chemotherapy‐induced neuropathic pain, greatly decreasing the dose of each drug required to produce efficacy (King et al, ). A continuation of quantitative research is required to determine the scope of these interactions, including how they affect the adverse effects of THC.…”

Is cannabidiol a drug acting on unconventional targets to control drug‐resistant epilepsy?

“…These effects are associated with side effects such as appetite alterations, nausea, diarrhea and other gastrointestinal alterations, sleepiness, weight changes, and fatigue, among others . It is known that THC augments the analgesic effects of CBD . On the other hand, CBD potentiates or reduces some effects induced by THC .…”

Searching for analgesic drug candidates alleviating oxaliplatin‐induced cold hypersensitivity in mice

“…In addition to its clinical utility, oxaliplatin is also used in pharmacological laboratories to induce a rodent model of CIPN‐related neuropathic pain that could be utilized in the search for novel therapies for CIPN prevention (Ohsawa et al., ) and treatment (Andoh, Kitamura, & Kuraishi, ; Deuis et al., ; Jiang et al., ; Kim et al., ; King et al., ; Pańczyk et al., ; K. Sałat et al., , ; Sałat & Sałat, ; Yoon, Lee, Roh, & Oh, ). To assess the effect of oxaliplatin on tactile allodynia, researchers worldwide take advantage of using von Frey filaments as an easy‐to‐use method.…”