Single and 13-Week Oral Toxicity Study of Fucoxanthin Oil from Microalgae in Rats

Iio, Kumiko; Okada, Yumika; Ishikura, Masaharu

doi:10.3358/shokueishi.52.183

Cited by 47 publications

(30 citation statements)

References 11 publications

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“…Furthermore, histological study suggested no abnormality was found in different tissues including liver, kidney, spleen, and gonadal, after repeating dose of 500 and 1000 mg/kg for 30 day in mice [10]. In addition, the genotoxic/mutagenic effects were also not found in mouse bone marrow cells [24,25]. Thus, compared to existing cancer cytotoxic chemotherapy, fucoxanthin can generate growth inhibition effects to multiple types of cancer cell with low toxicity.…”

Section: Resultsmentioning

confidence: 99%

Extracts from New Zealand Undaria pinnatifida Containing Fucoxanthin as Potential Functional Biomaterials against Cancer in Vitro

Wang

White

et al. 2014

JFB

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This study tested extracts from New Zealand seaweed Undaria pinnatifida containing fucoxanthin, in parallel with pure fucoxanthin, in nine human cancer cell lines, for anticancer activity. Growth inhibition effects of extracts from Undaria pinnatifida were found in all types of cancer cell lines in dose- and time- dependent manners. Cytotoxicity of fucoxanthin in three human non-cancer cell lines was also tested. Compared with pure fucoxanthin, our extracts containing low level of fucoxanthin were found to be more effective in inhibiting the growth of lung carcinoma, colon adenocarcinoma and neuroblastoma. Our results suggest that fucoxanthin is a functional biomaterial that may be used as a chemopreventive phytochemical or in combination chemotherapy. Furthermore, we show for the first time that some unknown compounds with potential selective anti-cancer effects may exist in extracts of New Zealand Undaria pinnatifida, and New Zealand Undaria pinnatifida could be used as a source for either functional biomaterial extraction or production of functional food.

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Section: Resultsmentioning

confidence: 99%

Extracts from New Zealand Undaria pinnatifida Containing Fucoxanthin as Potential Functional Biomaterials against Cancer in Vitro

Wang

White

et al. 2014

JFB

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“…showed no signs of genotoxicity in the bacterial reverse mutation test and micronucleus test in mice [26]. In addition, in a rat study, the 50% lethal single dose of FX was more than 2 g/kg of body weight and no elevated mortality or abnormalities were observed in a 13-week oral administration of FX in a dose of 200 mg/kg [27].…”

Section: Fx Sources and Toxicitymentioning

confidence: 92%

Fucoxanthin and lipid metabolism: A minireview

Muradian

Vaiserman

Min

et al. 2015

Nutrition, Metabolism and Cardiovascular Diseases

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“…This result suggested that the no observed adverse effect level of FX-containing oil extracted from microalga Chaetoseros sp. was 200 mg/kg body weight under the tested subchronic dose condition [24]. …”

Section: Toxicitymentioning

confidence: 99%

Fucoxantin: A Treasure from the Sea

et al. 2012

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The World Health Organization (WHO) estimates that 2.3 billion people will be overweight and 700 million obese in 2015. The reasons for this disastrous trend are attributed to the global tendency toward the reduced magnitude of exercise and physical activity and the increased dietary intake of fats, sugars and calories with reduced amount of vitamins and minerals. To prevent life-style-related diseases, like Metabolic Syndrome (MS), researchers’ attention is increasingly focusing on some of the so called “functional foods” which may be useful for their prevention and treatment. One of these functional ingredients is fucoxanthin (FX), a characteristic carotenoid present in edible brown seaweeds, such as Undaria pinnatifida (Wakame), Hijikia fusiformis (Hijiki), Laminaria japonica (Ma-Kombu) and Sargassum fulvellum. The increasing popularity of this molecule is certainly due to its anti-obesity effect, primarily detected by murine studies. These works revealed FX mediated induction of uncoupling protein-1 (UCP-1) in abdominal white adipose tissue (WAT) mitochondria, leading to the oxidation of fatty acids and heat production in WAT. Beyond this important role, in recent studies FX has shown a great antioxidant activity, anti-cancer, anti-diabetic and anti-photoaging properties. The aim of this review is to highlight the main effects of FX on human health.

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Single and 13-Week Oral Toxicity Study of Fucoxanthin Oil from Microalgae in Rats

Cited by 47 publications

References 11 publications

Extracts from New Zealand Undaria pinnatifida Containing Fucoxanthin as Potential Functional Biomaterials against Cancer in Vitro

Extracts from New Zealand Undaria pinnatifida Containing Fucoxanthin as Potential Functional Biomaterials against Cancer in Vitro

Fucoxanthin and lipid metabolism: A minireview

Fucoxantin: A Treasure from the Sea

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