2012
DOI: 10.1073/pnas.1120698109
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Single amino acid mutation in an ATP-binding cassette transporter gene causes resistance to Bt toxin Cry1Ab in the silkworm, Bombyx mori

Abstract: Bt toxins derived from the arthropod bacterial pathogen Bacillus thuringiensis are widely used for insect control as insecticides or in transgenic crops. Bt resistance has been found in field populations of several lepidopteran pests and in laboratory strains selected with Bt toxin. Widespread planting of crops expressing Bt toxins has raised concerns about the potential increase of resistance mutations in targeted insects. By using Bombyx mori as a model, we ide… Show more

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Cited by 200 publications
(173 citation statements)
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“…Very recently, the functionality for ATP-binding cassette transporter subfamily C member 2 (ABCC2) as Cry1 toxin receptor has been reported in Bombyx mori larvae (5), in accord with the role of this protein in the mechanism of Cry1 toxin resistance (41,42). Remarkably, B. mori ABCC2 protein (42) structurally resembles TcSSS protein in that both are multimembrane-spanning transporters (Fig.…”
Section: Discussionmentioning
confidence: 73%
See 1 more Smart Citation
“…Very recently, the functionality for ATP-binding cassette transporter subfamily C member 2 (ABCC2) as Cry1 toxin receptor has been reported in Bombyx mori larvae (5), in accord with the role of this protein in the mechanism of Cry1 toxin resistance (41,42). Remarkably, B. mori ABCC2 protein (42) structurally resembles TcSSS protein in that both are multimembrane-spanning transporters (Fig.…”
Section: Discussionmentioning
confidence: 73%
“…Remarkably, B. mori ABCC2 protein (42) structurally resembles TcSSS protein in that both are multimembrane-spanning transporters (Fig. 5).…”
Section: Discussionmentioning
confidence: 99%
“…Although ABCC2 mutations are reported to be recessive (33)(34)(35), the resistance conferred by insensitive Ace is in most cases semidominant. However, dominance levels of insensitive Ace alleles were shown to vary from recessivity to dominance and correlate with the activity of insensitive Ace forms in mosquito Culex pipiens.…”
Section: Discussionmentioning
confidence: 99%
“…2 and 3), and presumably in all other species of the tortricid subfamilies Olethreutinae and Tortricinae, which comprise almost 700 economically important pests worldwide (30). Whereas Rdl orthologs conferring resistance to cyclodiene insecticides are also Z-linked in other Lepidoptera (31,32), the Ace-1 and ABCC2 associated with insensitivity to organophosphates and carbamates, and resistance to Bacillus thuringiensis toxin Cry1Ab, respectively, are assignable to the autosomal linkage group corresponding to B. mori chromosome 15 in distantly related species (15,(33)(34)(35). By contrast, in most tortricids, the sex-linkage of these two genes is thus a direct consequence of F(Z;15).…”
Section: Discussionmentioning
confidence: 99%
“…Bombyx mori resistance to Cry1Ab has been conferred by a single amino acid mutation in ATP-binding cassette transporter gene (Atsumi et al, 2012).…”
Section: Molecular Mechanisms Of Resistancementioning
confidence: 99%