Single amino acid based self-assembled structure

Perween, Shama; Chandanshive, Balasaheb; Kotamarthi, Hema Chandra; Khushalani, Deepa

doi:10.1039/c3sm51054a

Cited by 74 publications

(93 citation statements)

References 30 publications

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“…[33] They obtained straight fibers with a flat ribbon-like textures from a 1 mM solution of Tyr in deionized water. However, they did not find any signature of secondary structural characteristics.…”

Section: Amino Acid Based Nanostructuresmentioning

confidence: 99%

Amino Acid Based Self‐assembled Nanostructures: Complex Structures from Remarkably Simple Building Blocks

Chakraborty

Gazit

2018

ChemNanoMat

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Amino acids are the simplest biological building blocks capable of forming discreet nanostructures by supramolecular self-assembly. The understanding of the process of organization of amino acid nanostructures is of fundamental importance for the study of metabolic diseases as well as for materials science applications. Although peptide self-assembled structures have been the topic of many review articles, much less attention has been devoted to the ability of amino acid building blocks, both natural and synthetic, to form ordered assemblies with defined architectures and notable physical properties, by the process of self-association. Herein, we try to shed light on amino acid based nanostructures, their fabrication and implications. We discuss self-assembled nanostructures, including hydrogels with nanoscale order, obtained from both modified and unmodified single amino acids. We also envision some future prospects in this emerging field.

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Section: Amino Acid Based Nanostructuresmentioning

confidence: 99%

Amino Acid Based Self‐assembled Nanostructures: Complex Structures from Remarkably Simple Building Blocks

Chakraborty

Gazit

2018

ChemNanoMat

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“…Weak interactions between complimentary amino acids occur in nature and their importance has been demonstrated in many biological processes, such as protein folding. These essential building blocks of life have their function dictated by the type of amino acids and interactions participating in their stabilisation …”

Section: Introductionmentioning

confidence: 99%

“…as producing a hydrogel containing crystals (the material was named a gel‐crystal) . The importance of investigating hydrogelation of Phe was raised recently when several studies correlated the aggregation of Phe with phenylketonuria and β‐amyloid‐based neurodegenerative conditions, such as Alzheimer's and Huntington's diseases . Considering the pathological implications of aggregation of Phe and the potential applications of Phe‐based hydrogels as drug delivery matrices, we developed amino acid based multi‐component gelating systems.…”

Section: Introductionmentioning

confidence: 99%

Supramolecular Amino Acid Based Hydrogels: Probing the Contribution of Additive Molecules using NMR Spectroscopy

Ramalhete

Nartowski

Sarathchandra

et al. 2017

Chemistry A European J

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Supramolecular hydrogels are composed of self‐assembled solid networks that restrict the flow of water. l‐Phenylalanine is the smallest molecule reported to date to form gel networks in water, and it is of particular interest due to its crystalline gel state. Single and multi‐component hydrogels of l‐phenylalanine are used herein as model materials to develop an NMR‐based analytical approach to gain insight into the mechanisms of supramolecular gelation. Structure and composition of the gel fibres were probed using PXRD, solid‐state NMR experiments and microscopic techniques. Solution‐state NMR studies probed the properties of free gelator molecules in an equilibrium with bound molecules. The dynamics of exchange at the gel/solution interfaces was investigated further using high‐resolution magic angle spinning (HR‐MAS) and saturation transfer difference (STD) NMR experiments. This approach allowed the identification of which additive molecules contributed in modifying the material properties.

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“…We observed that Tyr can form well‐ordered structures when deposited onto the different surfaces commonly used in transmission electron microscopy (TEM), atomic force microscopy (AFM), scanning electron microscopy (SEM), and optical microscopy. To date, only one study recently reported that Tyr can form distinct fibrillar structures 8. In addition, two independent studies have reported the adsorption of Tyr on metal surfaces, that is, Cu(111)9 and Ag(111) 10.…”

mentioning

confidence: 99%

Self‐Assembly of Tyrosine into Controlled Supramolecular Nanostructures

Ménard‐Moyon¹,

Venkatesh²,

Krishna³

et al. 2015

Chemistry A European J

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In the context of designing novel amino acid nanostructures, the capacity of tyrosine alone to form well-ordered structures under different conditions was explored. It was observed that Tyr can self-assemble into well-defined morphologies when deposited onto surfaces for transmission electron microscopy, atomic force microscopy, and scanning electron microscopy. The influence of various parameters that can modulate the self-assembly process, including concentration of the amino acid, aging time, and solvent, was studied. Different supramolecular architectures, including nanoribbons, branched structures, and fern-like arrangements were also observed.

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Single amino acid based self-assembled structure

Cited by 74 publications

References 30 publications

Amino Acid Based Self‐assembled Nanostructures: Complex Structures from Remarkably Simple Building Blocks

Amino Acid Based Self‐assembled Nanostructures: Complex Structures from Remarkably Simple Building Blocks

Supramolecular Amino Acid Based Hydrogels: Probing the Contribution of Additive Molecules using NMR Spectroscopy

Self‐Assembly of Tyrosine into Controlled Supramolecular Nanostructures

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