Síndrome de Zika congénito en la Argentina: presentación de dos casos clínicos

Pastrana, A; Albarracín, María de Los A; Hoffmann, Magdalena; Delturco, G; López, Raquel; R, Gil; Guzmán, Antonio Castillo; M, Del Barco; Espeche, Alberto

doi:10.5546/aap.2019.e635

Cited by 4 publications

(1 citation statement)

References 11 publications

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“…The first national case of congenital ZIKV syndrome (CZS) was reported in November 2016 in Tucumán. 2 The National Network of Congenital Anomalies (RENAC) reported an increase in the birth prevalence of microcephaly in Argentina, from 4.1 per 10 000 in 2009 to 2015 to 6.9 per 10 000 in 2016/17, although this increase was substantially lower compared with other countries in the region like Brazil, Colombia and Venezuela. [2][3][4] The last reported ZIKV case in Argentina was in early May, 2019.…”

Section: Introductionmentioning

confidence: 99%

Causes of Microcephaly in the Zika Era in Argentina: A Retrospective Study

Berberián

Bologna

Pérez

et al. 2021

Global Pediatric Health

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There are gaps in understanding the causes and consequences of microcephaly. This paper describes the epidemiological characteristics, clinical presentations, and etiologies of children presenting microcephaly during the Zika outbreak in Argentina. This observational retrospective study conducted in the pediatric hospital of Juan P. Garrahan reviewed the medical records of 40 children presenting microcephaly between March 2017 and November 2019. The majority (60%) were males and born full-term. At first evaluation, microcephaly was defined as congenital (31/40, 77%) and associated with other features (68%) such as seizures, developmental delay, non-progressive chronic encephalopathy, and West Syndrome. It was found manifestations restricted to central nervous system (55%), ocular (8/40, 20%), and acoustic (9/40, 23%) defects, and abnormal neuroimaging findings (31/39, 79%). Non-infectious diseases were the primary cause of isolated microcephaly (21/37, 57%), largely related to genetic diseases (13/21, 62%). Only 3 were children were diagnosed with Congenital Zika infection (3/16, 7.5%).

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Section: Introductionmentioning

confidence: 99%

Causes of Microcephaly in the Zika Era in Argentina: A Retrospective Study

Berberián

Bologna

Pérez

et al. 2021

Global Pediatric Health

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Pathophysiological and molecular considerations of viral and bacterial infections during maternal-fetal and –neonatal interactions of SARS-CoV-2, Zika, and Mycoplasma infectious diseases

Ferreira

Blasina

Rey

et al. 2022

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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During pregnancy, a series of physiological changes are determined at the molecular, cellular and macroscopic level that make the mother and fetus more susceptible to certain viral and bacterial infections, especially the infections in this and the companion review. Particular situations increase susceptibility to infection in neonates. The enhanced susceptibility to certain infections increases the risk of developing particular diseases that can progress to become morbidly severe. For example, during the current pandemic caused by the SARS-CoV-2 virus, epidemiological studies have established that pregnant women with COVID-19 disease are more likely to be hospitalized. However, the risk for intensive care unit admission and mechanical ventilation is not increased compared with nonpregnant women. Although much remains unknown with this particular infection, the elevated risk of progression during pregnancy towards more severe manifestations of COVID-19 disease is not associated with an increased risk of death. In addition, the epidemiological data available in neonates suggest that their risk of acquiring COVID-19 is low compared with infants (<12 months of age). However, they might be at higher risk for progression to severe COVID-19 disease compared with older children. The data on clinical presentation and disease severity among neonates are limited and based on case reports and small case series. It is well documented the importance of the Zika virus infection as the main cause of several congenital anomalies and birth defects such as microcephaly, and also adverse pregnancy outcomes. Mycoplasma infections also increase adverse pregnancy outcomes. This review will focus on the molecular, pathophysiological and biophysical characteristics of the mother/placental-fetal/neonatal interactions and the possible mechanisms of these pathogens (SARS-CoV-2, ZIKV, and Mycoplasmas) for promoting disease at this level.

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Health outcomes of children born/suspected with ZIKV: Protocol for the ZIKAction Paediatric Registry in Latin America and the Caribbean

Ruiz-Burga

Siqueira

Melbourne-Chambers

et al. 2021

Preprint

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Background: Although the number of Zika virus (ZIKV) cases has substantially declined in Latin America and the Caribbean since the 2015-2016 outbreaks, the cohort of children born at that time and affected by congenital zika syndrome (CZS) are now around 4-5 years old and experiencing an ongoing impact on their health and development. Gaps in our understanding remain regarding the outcomes of ZIKV exposure in utero and congenital infection and the consequences of congenital zika syndrome (CZS) for health throughout childhood. Methods: The ZIKAction Paediatric Registry is an international multi-centre registry of infants and children with documented ZIKV exposure in utero (i.e. born to mother with confirmed infection in pregnancy) and/or with confirmed or suspected congenital ZIKV infection. Clinical teams at participating sites in Argentina, Brazil and Jamaica conduct retrospective case note reviews of children eligible for inclusion in the Registry and enter pseudonymised data into a central Registry database, with additional data collected prospectively on routine follow-up at some sites. Data collected will include sociodemographic, maternal and pregnancy information, delivery information and newborn assessment, paediatric clinical assessments (physical, neurological, developmental, ophthalmological, audiological), and laboratory results conducted as part of local standard of care. The ZIKAction Paediatric Registry network will conduct pooled analyses to address questions relating to characteristics, health and neurodevelopmental outcomes of this population. The Registry is embedded within a larger programme of research studies conducted by ZIKAction. Discussion: As the health outcomes of children affected by ZIKV continue to unfold, this paediatric registry will provide comprehensive data on their clinical and neurodevelopmental outcomes, growth and management, as well as on later sequelae. This will inform their support and care and provide potential insights on pathogenesis of the disease, of importance to currently affected families and for the response to possible future outbreaks. It will highlight the service needs of the affected populations in Latin America and the Caribbean and allow the identification of potential participants for future studies.

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Síndrome de Zika congénito en la Argentina: presentación de dos casos clínicos

Cited by 4 publications

References 11 publications

Causes of Microcephaly in the Zika Era in Argentina: A Retrospective Study

Causes of Microcephaly in the Zika Era in Argentina: A Retrospective Study

Pathophysiological and molecular considerations of viral and bacterial infections during maternal-fetal and –neonatal interactions of SARS-CoV-2, Zika, and Mycoplasma infectious diseases

Health outcomes of children born/suspected with ZIKV: Protocol for the ZIKAction Paediatric Registry in Latin America and the Caribbean

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