Síndrome de secreción inadecuada de hormona antidiurética asociado a hepatocarcinoma

Muela-Molinero, Alberto; Río, Beatriz Ballesteros del; Paz, F Nistal de; Plaza, Francisco Jorquera

doi:10.1016/s0025-7753(03)73959-1

Cited by 2 publications

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References 5 publications

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“…Although SIADH has been described in the setting of central nervous system disorders, secondary to medications, and in some malignancies [mainly small cell lung cancer, head and neck cancer, olfactory neuroblastoma (esthesioneuroblastoma), and blood malignancies] [ 2 – 4 ], it is very rarely associated with primary hepatocellular carcinoma. There have only been 3 previous remotely reported cases of this association based on our comprehensive and extensive review of the literature [ 5 – 7 ]. We report a case of a Guatemalan man diagnosed with SAIDH in the setting of primary hepatocellular carcinoma.…”

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confidence: 99%

Syndrome of Inappropriate Anti-Diuretic Hormone Secondary to Non-Cirrhotic Primary Hepatocellular Carcinoma

et al. 2015

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Patient: Male, 71Final Diagnosis: SIADHSymptoms: Cachexia • confusionMedication: —Clinical Procedure: Percutaneous liver biopsySpecialty: OncologyObjective:Rare diseaseBackground:The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is usually seen in pulmonary malignancies, central nervous system disorders, and secondary to medications. SIADH has very rarely been encountered in primary hepatocellular carcinoma. Two cases were reported in Japan and 1 case in Spain after extensive investigation of the medical records.Case Report:We report a case of a 71-year-old man who presented with confusion, cachexia, and abdominal symptoms in the form of vomiting and abdominal discomfort. On the initial work-up, SIADH diagnosis was made. After an extensive work-up, the reason for SIADH turned out to be a newly diagnosed hepatocellular carcinoma. The precipitating factor for the cancer was not identified by history or by work-up. No metastasis was identified. Liver functions were preserved but patient was severely malnourished.Conclusions:SIADH can occur as a para-malignant feature of the malignancy. In our case, it was related to the hepatocellular carcinoma, which is a malignancy very rare to cause SIADH.

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Section: Introductionmentioning

confidence: 99%

Syndrome of Inappropriate Anti-Diuretic Hormone Secondary to Non-Cirrhotic Primary Hepatocellular Carcinoma

et al. 2015

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Hyponatremia Associated with Hepatocellular Carcinoma

et al. 2016

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Hyponatremia is the most common electrolyte abnormality in clinical practice, and a differential diagnosis of the etiologic disorders is crucial because hyponatremia is associated with many different disease states including malignancies. Although only a few cases of hyponatremia with hepatocellular carcinoma (HCC) have been previously reported, the abnormal expression of arginine vasopressin (AVP) in tumor cells has not been demonstrated. We herein present a rare case of hyponatremia associated with the aberrant expression of AVP in tumor cells of HCC. This case suggests that an extensive diagnostic work-up is needed in patients with hyponatremia because hyponatremia may provide diagnostic clues for the presence of other underlying disorders.

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Síndrome de secreción inadecuada de hormona antidiurética asociado a hepatocarcinoma

Cited by 2 publications

References 5 publications

Syndrome of Inappropriate Anti-Diuretic Hormone Secondary to Non-Cirrhotic Primary Hepatocellular Carcinoma

Syndrome of Inappropriate Anti-Diuretic Hormone Secondary to Non-Cirrhotic Primary Hepatocellular Carcinoma

Hyponatremia Associated with Hepatocellular Carcinoma

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