Síndrome de piernas inquietas en esclerosis múltiple: evaluación de factores de riesgo y repercusión clínica

Hernández, Lucía Lebrato; León, María Prieto; Fuentes, Nathalie; Sánchez, Antonio José Uclés; Chocán, J L Casado; Sánchez, María Díaz

doi:10.1016/j.nrl.2018.12.010

Cited by 9 publications

(4 citation statements)

References 30 publications

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“…RLS prevalence was found to be elevated in PwMS with an odds ratio of 3–4 in PwMS versus control subjects. In agreement with observations by Minar et al [ 66 ], RLS prevalence varied widely from study to study, ranging from 12.12 to 57.50% in PwMS and 2.5% to 18.3% in controls, one study reported faster MS progression in those patients with concomitant RLS [ 67 ]. Supporting the concept of dopaminergic involvement in RLS in PwMS, data from two studies showed that the risk of RSL increased in PwMS with spinal cord lesions [ 66 , 68 ].…”

Section: Resultssupporting

confidence: 90%

“…Comorbidities have an adverse influence on outcome. Different comorbidities were found to be associated with disability and clinical features of disease progression in PwMS [ 47 ],RLS was associated with faster MS progression [ 67 ], migraine with a more symptomatic course of MS [ 70 ], and hypertension with structural brain changes [ 30 ] in PwMS. Other studies reported that asthma and rheumatoid arthritis were associated with MS relapse [ 14 ], and insulin resistance with both EDSS and inflammatory/oxidative stress markers [ 98 ] in PwMS.…”

Section: Discussionmentioning

confidence: 99%

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A global view of comorbidity in multiple sclerosis: a systematic review with a focus on regional differences, methodology, and clinical implications

2020

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Multiple sclerosis (MS) is a chronic autoimmune disorder of the central nervous system which is associated with numerous comorbidities. These include cardiovascular disease, psychiatric and neurologic disturbances, restless leg syndrome, migraine, cancer, autoimmune diseases, and metabolic disorders. Comorbid disease is an important consideration for clinicians treating patients with MS; early presentation of comorbidities can obscure or delay MS diagnosis, as well as significantly impacting the disease course. Improved understanding of comorbidities and their emergence in MS populations is important for improving the quality of life and optimizing treatment for patients. Therefore, we evaluated published studies reporting epidemiologic data on comorbidities and their associated impact on disease progression in patients with MS (PwMS). The prevalence of neurologic, cardiovascular, metabolic, and autoimmune comorbidities was elevated in PwMS in general, and furthermore, this adversely affected a broad range of outcomes. Compared with PwMS, cancer rates in people without MS or the general population were lower, which should prompt further studies into the mechanisms of both diseases. Studies were under-represented in many regions owing to the latitudinal gradient of MS and possible underfunding of studies.

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Section: Resultssupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

A global view of comorbidity in multiple sclerosis: a systematic review with a focus on regional differences, methodology, and clinical implications

2020

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“…Sleep apnea and insomnia in the general population is associated with greater incidence of work related disability. [74][75][76][77] People with multiple sclerosis with sleep apnea or RLS have greater disability, 78,79 higher levels of fatigue, 80 and lower quality of life 81 than people with multiple sclerosis without these sleep disorders. In people with traumatic brain injury, insomnia is associated with poorer quality of life as well.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Sleep Disorders on Functional Recovery and Participation Following Stroke: A Systematic Review and Meta-Analysis

Fulk

Boyne

Hauger

et al. 2020

Neurorehabil Neural Repair

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Background Adequate sleep is vital for health and quality of life. People with stroke and a concomitant sleep disorder may have poorer outcomes than those without a sleep disorder. Objective To systematically evaluate the published literature to determine the impact of sleep disorders on physical, functional recovery at the activity and participation level after stroke. Methods A systematic review was conducted using PubMed, CINAHL, Scopus, and PsycINFO. Studies were selected that reported outcomes on physical, functional recovery at the activity and participation levels in participants with stroke and a diagnosed sleep disorder. A meta-analysis was performed on included studies that reported Barthel Index (BI) and modified Rankin Scale (mRS) scores. Results: A total of 33 studies were included in the systematic review with 9 of them in the meta-analysis. The mean mRS score was 0.51 points higher in participants with stroke and sleep disorders versus participants with stroke without sleep disorder [95% CI: 0.23-0.78]. The mean BI score was 10.2 points lower in participants with stroke and sleep disorders versus participants with stroke without sleep disorder [95% CI: −17.9 to −2.6]. Conclusions People with stroke and a sleep disorder have greater functional limitations and disability than those without a sleep disorder. Rehabilitation professionals should screen their patients with stroke for potential sleep disorders and further research is needed to develop sleep and rehabilitation interventions that can be delivered in combination. PROSPERO registration number: CRD42019125562.

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“…Clinical conditions related to MS, such as stress, depression, exhaustion, and sleep complications, adversely affect the life quality of patients 6 . In recent years, research has been reported increased RLS pervasiveness in MS patients 7,8 . Giannaki et al reported that depression, the quality of sleep, and exhaustion were more acute in MS patients (R / S + RLS) 9 .…”

Section: Introductionmentioning

confidence: 99%

Alpha-synuclein levels in multiple sclerosis patients with restless leg syndrome

Çakına

Yücel

Polat

et al. 2020

Cukurova Medical Journal

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The restless legs syndrome is more frequent and critical in Multiple Sclerosis patients, and it harms their general well-being and life quality. Alpha-synuclein is a synuclein protein that can have an impact on the pathway of signaling, affecting the Dopamin 2 receptor and its receptor trafficking. Studies have shown that the decrease in dopamine 2 receptor and Restless Legs Syndrome disease are correlated. This study is aimed to ascertain the alpha-synuclein level in multiple sclerosis patients with restless legs syndrome. Materials and Methods: We took blood samples from 40 multiple sclerosis patients and 20 healthy individuals. Half of the patient group had Multiple Sclerosis with restless leg syndrome. In the study groups, the alpha-synuclein level was determined by quantitative real-time polymerase chain reaction (qRT-PCR) and enzyme-dependent immunosorbent assay (ELISA). Results: Alpha-synuclein gene expression level was found or be significantly lower in restless leg syndrome patients with multiple sclerosis than the Alpha-synuclein gene expression level in the control group. Conclusion: Alpha-synuclein may have an impact on the pathogenesis of the restless leg syndrome of multiple sclerosis disease. Further investigations are required to determine the impact of alpha-synuclein in the pathogenesis of restless leg syndrome in multiple sclerosis disease.

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Síndrome de piernas inquietas en esclerosis múltiple: evaluación de factores de riesgo y repercusión clínica

Cited by 9 publications

References 30 publications

A global view of comorbidity in multiple sclerosis: a systematic review with a focus on regional differences, methodology, and clinical implications

A global view of comorbidity in multiple sclerosis: a systematic review with a focus on regional differences, methodology, and clinical implications

The Impact of Sleep Disorders on Functional Recovery and Participation Following Stroke: A Systematic Review and Meta-Analysis

Alpha-synuclein levels in multiple sclerosis patients with restless leg syndrome

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