Revista Clínica Española

2000

DOI: 10.1016/s0014-2565(00)70017-8

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Síndrome de Churg-Strauss. Nuestra experiencia en dos décadas

Juan José Ríos Blanco

¹

,

Jorge Gómez Cerezo

²

,

I. Suárez García

³

et al.

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Cited by 13 publications

References 15 publications

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Churg‐Strauss syndrome with poor‐prognosis factors: A prospective multicenter trial comparing glucocorticoids and six or twelve cyclophosphamide pulses in forty‐eight patients

et al. 2007

Arthritis & Rheumatism

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Objective. To compare long and short durations of adjunctive cyclophosphamide for the treatment of severe ChurgStrauss syndrome (CSS). Methods. In this prospective multicenter therapeutic trial, 48 patients with CSS with at least 1 poor-prognosis factor at baseline were treated with glucocorticoids and either 12 or 6 intravenous cyclophosphamide pulses. Results. At 8 years, complete remission rates and severe side effects of therapy were comparable for both groups. The overall difference in relapses was not significant between the 12-pulse and the 6-pulse regimens (P ‫؍‬ 0.07), but when considering only the number of mild relapses this difference became statistically significant (P < 0.02). Although the total number of inclusions was not reached, the study was stopped prematurely in response to the superiority of the 12-pulse regimen. Conclusion. We concluded that 12 cyclophosphamide pulses were better able to control severe CSS than a 6-pulse regimen. The optimal duration of therapy remains to be determined.

Churg‐Strauss syndrome with poor‐prognosis factors: A prospective multicenter trial comparing glucocorticoids and six or twelve cyclophosphamide pulses in forty‐eight patients

et al. 2007

Arthritis & Rheumatism

View full text Add to dashboard Cite

Objective. To compare long and short durations of adjunctive cyclophosphamide for the treatment of severe ChurgStrauss syndrome (CSS). Methods. In this prospective multicenter therapeutic trial, 48 patients with CSS with at least 1 poor-prognosis factor at baseline were treated with glucocorticoids and either 12 or 6 intravenous cyclophosphamide pulses. Results. At 8 years, complete remission rates and severe side effects of therapy were comparable for both groups. The overall difference in relapses was not significant between the 12-pulse and the 6-pulse regimens (P ‫؍‬ 0.07), but when considering only the number of mild relapses this difference became statistically significant (P < 0.02). Although the total number of inclusions was not reached, the study was stopped prematurely in response to the superiority of the 12-pulse regimen. Conclusion. We concluded that 12 cyclophosphamide pulses were better able to control severe CSS than a 6-pulse regimen. The optimal duration of therapy remains to be determined.

Vasculitic neuropathy

Vrancken,

Said

2013

Handbook of Clinical Neurology

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No abstract

Perspectiva histórica de la clasificación de las vasculitis

Barbado-Hernández

¹

,

²

,

³

et al. 2007

Actas Dermo-Sifiliográficas

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No abstract

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