Síncope como Expressão Fenotípica da Amiloidose Hereditária por Transtirretina Val142Ile (Val122Ile)

Nunes, Nágela Simão Vinhosa; Carvalho, João Paulo; Costa, Fernanda Salomão; Nacif, Marcelo Souto; Dominato, Joelma; Mesquita, Cláudio Tinoco; Mesquita, Evandro Tinoco

doi:10.36660/abc.20180130

Cited by 2 publications

(2 citation statements)

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“…Achados de hipersensibilidade do seio carotídeo, ocorre mais em idosos, normalmente causado pelo uso de colares ou gravatas apertadas, mobilização brusca com o pescoço e a simples mobilidade do pescoço resulta na perda de consciência. Esse mecanismo é raro e gera à bradicardia e redução da pressão arterial, resultante da exagerada reação dos receptores localizados no par de carótidas do pescoço que ocasiona o freio dos reflexos elétricos da ação cardíaca (NUNES, 2020).…”

Section: Resultsunclassified

Considerações gerais sobre a síncope: uma abordagem clínica

Pena¹,

Barbosa²,

Rocha³

et al. 2022

BJDV

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O seguinte estudo objetivou descrever sobre as etiologias e o respectivo quadro clínico da síncope. A síncope é classificado como um sintoma de perda da consciência devido redução do fluxo sanguíneo cerebral, secundário a uma etiologia. Tal evento costuma ser confundido com outras condições associadas a perda de conhecimento, apesar de para se diagnosticar como síncope é necessário descartar demais alterações. A síncope é uma condição que têm como fisiopatologia o hipofluxo de sangue no cérebro, mas conta com diversas causas como a neuromediada, ortostática, cardíaca, cerebrovascular e até idiopática, resultam em quadros clínicos distintos e complicações, mas o mesmo desfecho. Tal evento necessita ser investigado e detectado de imediato, por história clínica, exame físico e complementares.

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Section: Resultsunclassified

Considerações gerais sobre a síncope: uma abordagem clínica

Pena¹,

Barbosa²,

Rocha³

et al. 2022

BJDV

View full text Add to dashboard Cite

show abstract

“…The description of clinical characteristics and outcomes of syncope in patients with amyloid cardiomyopathy is limited to a couple of small retrospective studies focused on patients with light chain amyloidosis [10,14]. To the best of our knowledge, the mechanisms and prognostic implications of syncope in patients with ATTR-CM have not been studied yet, beyond a few anecdotal case reports [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Syncope in patients with transthyretin amyloid cardiomyopathy: clinical features and outcomes

Barge‐Caballero

López‐Pérez

et al. 2022

Postgraduate Medicine

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Background:We aimed to describe the clinical characteristics, underlying causes and outcomes of syncope in patients with transthyretin amyloid cardiomyopathy (ATTR-CM). Methods:The clinical profile and underlying causes of syncopal episodes were reviewed in a cohort of 128 patients with ATTR-CM enrolled from January 2018 to June 2020 in a prospective multicentre registry in 7 hospitals of Galicia (Spain). After enrollment, patients were followed during a median period of 520 days.The effect of syncope on all-cause mortality was assessed by means of multivariate Cox´s regression.Results: Thirty (23.4%) patients had a history of previous syncope as a clinical antecedent before being enrolled in the prospective phase of the registry, and 4 (3.1%) experienced a first episode of syncope thereafter. The estimated incidence density rate of syncope during the prospective follow-up period after registry enrollment was 71.9 episodes per 1000 patients-year (95% Confidence Interval (CI) 32.8-111.1).The estimated overall prevalence of syncope was 26.6% (95% CI 18.9%-34.2%). Cardiac arrhythmias (n = 11, 32.3%), structural diseases of the heart or great vessels (n = 5, 14.7%), a neurally mediated reflex (n = 6, 17.6%), and orthostatic hypotension (n = 4, 11.8%) were identified as probable underlying causes of syncope; in 8 (23.6%) patients, syncope remained unexplained. Patients with syncope had increased nonadjusted all-cause mortality than patients without it (univariate hazard-ratio 3.37; 95% CI 1.43-7.94). When other independent predictors of survival were added to the survival model, this association was no longer statistically significant (multivariate hazard-ratio 1.81, 95% CI 0.67-4.84).Conclusions: Syncope is frequent in patients with ATTR-CM. This study could not demonstrate an independent association between syncope and mortality in those individuals.

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Síncope como Expressão Fenotípica da Amiloidose Hereditária por Transtirretina Val142Ile (Val122Ile)

Cited by 2 publications

References 0 publications

Considerações gerais sobre a síncope: uma abordagem clínica

Considerações gerais sobre a síncope: uma abordagem clínica

Syncope in patients with transthyretin amyloid cardiomyopathy: clinical features and outcomes

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