Sinapic and ferulic acid phenethyl esters increase the expression of steroidogenic genes in MA-10 tumor Leydig cells

Basque, Audrey; Touaibia, Mohamed; Martin, Luc J.

doi:10.1016/j.tiv.2022.105505

Cited by 5 publications

(5 citation statements)

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“…cells [9]. Moreover, genes encoding enzymes contributing to cholesterol and stero synthesis are increased by sinapic acid phenethyl ester, whereas ferulic acid ph ester increases cAMP-dependent STAR protein expression.…”

Section: Hydroxycinnamic Acid Phenethyl Ester Derivativesmentioning

confidence: 99%

“…Present in many plants, hydroxycinnamic acids are biosynthesized via the shikimic pathway with L-tyrosine or L-phenylalanine, via methylation, deamination, or hydroxylation reactions [ 155 ]. We recently reported that treatments with 10 μM of sinapic or ferulic acid phenethyl esters ( Figure 3 ) increase progesterone production in MA-10 Leydig cells [ 9 ]. Moreover, genes encoding enzymes contributing to cholesterol and steroid biosynthesis are increased by sinapic acid phenethyl ester, whereas ferulic acid phenethyl ester increases cAMP-dependent STAR protein expression.…”

Section: Natural Antioxidants Contributing To the Optimal Production ...mentioning

confidence: 99%

“…All relevant scientific works identified as suitable for this topic were included in this review. This literature review will focus on natural polyphenol antioxidants because of their potential to enhance the steroidogenic capacity of Leydig cells, as demonstrated by our laboratory research [ 6 , 7 , 8 , 9 , 10 ]. In addition, polyphenolic compounds have anti-aging properties such as the capacity to inhibit apoptosis caused by reactive oxygen species, and the ability to increase the activity of oxidative stress-limiting enzymes like superoxide dismutase, glutathione peroxidase and catalase [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Prevention of Male Late-Onset Hypogonadism by Natural Polyphenolic Antioxidants

Martin,

Touaibia

2024

Nutrients

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Androgen production primarily occurs in Leydig cells located in the interstitial compartment of the testis. In aging males, testosterone is crucial for maintaining muscle mass and strength, bone density, sexual function, metabolic health, energy levels, cognitive function, as well as overall well-being. As men age, testosterone production by Leydig cells of the testes begins to decline at a rate of approximately 1% per year starting from their 30s. This review highlights recent findings concerning the use of natural polyphenolics compounds, such as flavonoids, resveratrol, and phenolic acids, to enhance testosterone production, thereby preventing age-related degenerative conditions associated with testosterone insufficiency. Interestingly, most of the natural polyphenolic antioxidants having beneficial effects on testosterone production tend to enhance the expression of the steroidogenic acute regulatory protein (Star) gene in Leydig cells. The STAR protein facilitates the entry of the steroid precursor cholesterol inside mitochondria, a rate-limiting step for androgen biosynthesis. Natural polyphenolic compounds can also improve the activities of steroidogenic enzymes, hypothalamus-pituitary gland axis signaling, and testosterone bioavailability. Thus, many polyphenolic compounds such as luteolin, quercetin, resveratrol, ferulic acid phenethyl ester or gigantol may be promising in delaying the initiation of late-onset hypogonadism accompanying aging in males.

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Section: Hydroxycinnamic Acid Phenethyl Ester Derivativesmentioning

confidence: 99%

Section: Natural Antioxidants Contributing To the Optimal Production ...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prevention of Male Late-Onset Hypogonadism by Natural Polyphenolic Antioxidants

Martin,

Touaibia

2024

Nutrients

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“…Saeedavi et al [ 324 ] reported that sinapic acid may be a new therapeutic potential to treat allergic asthma through suppressing T-helper 2 immune responses. Sinapic acid phenethyl ester boosts gene expression related to the cholesterol metabolic process [ 325 ]. Hu et al [ 326 ] indicated that sinapic acid can be utilized as an effective chemo preventive agent against lung carcinogenesis.…”

Section: Hydroxycinnamic Acids ( P -Coumaric Acid ...mentioning

confidence: 99%

Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

2023

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Phenolic compounds and flavonoids are potential substitutes for bioactive agents in pharmaceutical and medicinal sections to promote human health and prevent and cure different diseases. The most common flavonoids found in nature are anthocyanins, flavones, flavanones, flavonols, flavanonols, isoflavones, and other sub-classes. The impacts of plant flavonoids and other phenolics on human health promoting and diseases curing and preventing are antioxidant effects, antibacterial impacts, cardioprotective effects, anticancer impacts, immune system promoting, anti-inflammatory effects, and skin protective effects from UV radiation. This work aims to provide an overview of phenolic compounds and flavonoids as potential and important sources of pharmaceutical and medical application according to recently published studies, as well as some interesting directions for future research. The keyword searches for flavonoids, phenolics, isoflavones, tannins, coumarins, lignans, quinones, xanthones, curcuminoids, stilbenes, cucurmin, phenylethanoids, and secoiridoids medicinal plant were performed by using Web of Science, Scopus, Google scholar, and PubMed. Phenolic acids contain a carboxylic acid group in addition to the basic phenolic structure and are mainly divided into hydroxybenzoic and hydroxycinnamic acids. Hydroxybenzoic acids are based on a C6-C1 skeleton and are often found bound to small organic acids, glycosyl moieties, or cell structural components. Common hydroxybenzoic acids include gallic, syringic, protocatechuic, p-hydroxybenzoic, vanillic, gentistic, and salicylic acids. Hydroxycinnamic acids are based on a C6-C3 skeleton and are also often bound to other molecules such as quinic acid and glucose. The main hydroxycinnamic acids are caffeic, p-coumaric, ferulic, and sinapic acids.

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“…As a new product, ferulic acid is being known to the public. At the same time, ferulic acid has very important potential application value in the treatment of Parkinson's disease, Alzheimer's disease and tumor [4][5][6] . At present, many studies have proved that ferulic acid also has a very important application value in ophthalmic diseases.…”

Section: Introductionmentioning

confidence: 99%

The Potential Values of Ferulic Acid in Ophthalmic Diseases

Wang

Yao

et al. 2023

Preprint

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Ferulic acid, as a common polyphenol in Chinese herbal medicine, is widely found in rice, vegetables and fruits. It has important antioxidant effects and has an effect in a variety of diseases. However, the mechanism of its antioxidant function is very complex, including regulation of pro-inflammatory factors, scavenging free radicals and inhibition of lipid peroxidation. The signaling pathway of ferulic acid in exerting its antioxidant effect has not been fully found. Recent studies have found that ferulic acid has a very important potential application value in the treatment of ophthalmic diseases, including glaucoma, cataract, age-related macular degeneration, etc. This paper reviews the effects and referring signaling pathway of ferulic acid in eye diseases and conclude the potential signal pathways of ferulic acid in order to provide new ideas for traditional Chinese medicine in the treatment of eye diseases.

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Sinapic and ferulic acid phenethyl esters increase the expression of steroidogenic genes in MA-10 tumor Leydig cells

Cited by 5 publications

References 39 publications

Prevention of Male Late-Onset Hypogonadism by Natural Polyphenolic Antioxidants

Prevention of Male Late-Onset Hypogonadism by Natural Polyphenolic Antioxidants

Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

The Potential Values of Ferulic Acid in Ophthalmic Diseases

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