Simvastatin treatment improves survival in a murine model of burn sepsis: Role of interleukin 6

Abstract

Infection is the most common and most serious complication of a major burn injury related to burn size. Despite improvements in antimicrobial therapies sepsis still accounts for 50–60% of deaths in burn patients. Given the acute onset and unpredictable nature of sepsis, primary prevention was rarely attempted in its management. However, recent studies have demonstrated that statin treatment can decrease mortality is a murine model of sepsis by preservation of cardiac function and reversal of inflammatory alterations. In addition, it has been shown that treatment with statins is associated with reduced incidence of sepsis in human patients. In the current study groups of CD1 male mice (n=12) were anesthetized and subjected to a dorsal 30% TBSA scald burn injury. Starting 2 hours post burn, the animals were divided into a treatment group receiving 0.2 µ/g simvastatin or a sham group receiving placebo. Simvastatin and placebo were administered by intraperitoneal injection with two dosing regimens; once daily and every 12 hours. On Post burn day 7 cecal ligation and puncture with a 21-gauge needle was performed under ketamine/xylazine anesthesia and the two different dosing schedules were continued. A simvastatin dose dependant improvement in survival was observed in the burn sepsis model.

Undiagnosed medical comorbidities in the uninsured

“…23 Preinjury statin use has been associated with an 83% reduction in burn-related death. 24 A-blockers and statins may affect mortality by influencing the inflammatory burden as denoted by lower interleukin 6 levels 25 and lower metabolic overdrive 26 in various injury models. Insurance allows access to health care and medical management of cardiac disease and hypertension potentially blunting inflammatory responses thereby improving mortality.…”

δ-Amyrone inhibits lipopolysaccharide-induced inflammatory cytokines and protects against endotoxic shock in mice

“…IL-6, another crucial pro-inflammatory cytokine participating in inflammation, is produced by various cell types and exerts pleiotropic effects on different organ systems. Changed IL-6 production has been found in inflammatory states such as sepsis [27]. NO is a M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT 18 short-lived small molecule which plays a crucial role in various physiological processes.…”

Protective effects of simvastatin administered in the experimental hepatic ischemia-reperfusion injury rat model

“…Group III (I/R 2.5 mg/kg SV) was treated similarly to the I/R group, but also received i.p. injections of 1 mL of 2.5 mg/kg SV, 60 min before the I/R [8]. Group IV (I/R 5.0 mg/kg SV) was treated similarly to group III rats but received 1 mL of 5.0 mg/kg SV.…”