Simvastatin treatment does not affect serum Vitamin D concentrations in patients with dyslipidemia: A randomized double-blind placebo-controlled cross-over trial

Mazidi, Mohsen; Rokni, Haleh; Sahebkar, Amirhosein; Mohammadi, Akram Miramin; Ghayour‐Mobarhan, Majid; Ferns, Gordon A.

doi:10.4103/2008-7802.183652

Cited by 12 publications

(10 citation statements)

References 19 publications

(25 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Perhaps, this could be the reason that most recent studies on this pleotropic effect of statins have failed to show any significant increase in vitamin D levels. 19 , 23 A recent meta-analysis of data from seven studies failed to show any significant effect of statins treatment on plasma concentrations of vitamin D. 9 All these reports lend support to our current results indicating lack of association between statin use and serum levels of vitamin D in type 2 DM patients. The multiple linear regression model to investigate this relationship while adjusting for other related factors mentioned above is a strength of this study.…”

Section: Discussionsupporting

confidence: 79%

“… 18 Similar results have been found by Mazidi et al on an Iranian population of patients with dyslipidemia. 19 On the contrary, Sathyapalan et al have reported increased concentration of 25(OH)D following therapy with atorvastatin in type 2 DM patients in UK. 20 Similarly, 4 studies (two carried out in Turkey, one in Spain and another one in Germany) have also shown increased serum levels of 25(OH)D following treatment with rosuvastatin and atorvastatin.…”

Section: Discussionmentioning

confidence: 96%

See 1 more Smart Citation

Lack of association of statin use with Vitamin D levels in a hospital based population of type 2 diabetes mellitus patients

Iqbal¹,

Islam²,

Azam³

et al. 2018

Pak J Med Sci

View full text Add to dashboard Cite

Objective:To investigate the relationship of statins (drug given to reduce serum levels of LDL-cholesterol) on vitamin D levels of Pakistani type 2 diabetes mellitus (DM) patients in a hospital in Karachi.Methods:In a cross-sectional survey, 312 consecutive patients with type 2 DM (219 males and 93 females, age 22-70 years) were recruited with informed consent. A questionnaire was administered to find out whether they were statin users or non-users. Serum was analyzed for concentrations of 25(OH) vitamin D [25(OH)D] and other related biomarkers such as serum cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol, phosphate and calcium using kit methods. Multiple Linear Regression was used to evaluate association of statin use with serum levels of vitamin D while adjusting for related covariates including duration of statin use, duration of type 2 DM and smoking.Results:Mean concentrations of serum cholesterol, and LDL-cholesterol were lower among statin users compared to statin non-users (P < 0.01), while HDL-cholesterol levels were higher (P<0.01). No relationship was observed between statin use and serum levels of vitamin D (P=0.768), when adjusted for age, gender, BMI, duration of type 2 DM, smoking, serum cholesterol and LDL-cholesterol. The adjusted regression coefficient (β) and standard error [SE(β)] for statin use duration were 0.012 (0.042), when serum levels of vitamin D was taken as an outcome.Conclusion:Lack of association was found between statin use and vitamin D levels in a hospital-based population of Pakistani patients with type 2 DM.

show abstract

Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 96%

Lack of association of statin use with Vitamin D levels in a hospital based population of type 2 diabetes mellitus patients

Iqbal¹,

Islam²,

Azam³

et al. 2018

Pak J Med Sci

View full text Add to dashboard Cite

show abstract

“…In our study, 25(OH)D concentrations did not improve in the rosuvastatin group and, in fact, decreased a little over the 96-week study. Other studies have shown similar results 49–54 . In the Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) trial, a 3-year randomized, placebo controlled trial of atorvastatin in over 200 children and young adults with systemic lupus erythematosus (SLE), 25(OH)D concentrations did not change appreciably and were similar to the placebo group over the course of the study 54 .…”

Section: Discussionsupporting

confidence: 74%

Baseline Vitamin D Deficiency Decreases the Effectiveness of Statins in HIV-Infected Adults on Antiretroviral Therapy

Hileman

Tangpricha

Sattar³

et al. 2017

JAIDS Journal of Acquired Immune Deficiency Syndromes

View full text Add to dashboard Cite

Objective Vitamin D deficiency is common in HIV. Statins may increase vitamin D and it is unknown whether vitamin D modifies the effect of statins on cardiovascular disease. Design SATURN-HIV was a 96-week, randomized, placebo-controlled trial designed to evaluate the effect of rosuvastatin on immune activation and subclinical vascular disease in HIV-infected adults on antiretroviral therapy. This analysis focuses on the pre-specified secondary endpoint 25-hydroxyvitamin D [25(OH)D] concentrations. Methods Mixed effects linear modeling and ANOVA were used to assess the rosuvastatin effect on plasma 25(OH)D concentrations over time and to determine whether baseline vitamin D modifies the rosuvastatin effect on changes in outcomes over the trial. Results 147 adults were randomized (72 to rosuvastatin, 75 to placebo); 78% were men, 68% African American, with mean age of 45 years. Baseline 25(OH)D concentrations were similar (overall mean 18 ng/ml) with 65% of participants below 20 ng/ml. Changes in 25(OH)D at 96 weeks were small and not significant within- or between-rosuvastatin and placebo groups. There were significant group by vitamin D status interactions for changes in LDL-cholesterol, proportion of patrolling monocytes expressing tissue factor (CD14dimCD16+TF+), lipoprotein-associated phospholipase A2 and common carotid artery intima media thickness at most time points. For each of these outcomes, the beneficial effects of rosuvastatin were either not apparent or attenuated in participants with 25(OH)D <20 ng/ml. Conclusion While 25(OH)D did not change with rosuvastatin, baseline vitamin D deficiency decreased the effectiveness of rosuvastatin. Vitamin D supplementation may be warranted for deficient patients initiating statin therapy.

show abstract

“…In contrast, Renjmark et al in a small randomized controlled trial among healthy postmenopausal women reported no significant differences in plasma 25(OH)D levels between subjects treated with simvastatin 40 mg/day for a year compared with their counterparts receiving placebo [15]. Likewise, Mazidi et al previously demonstrated in a randomized, double-blind, placebo-controlled trial lasting 30 days that simvastatin 40 mg/day did not have a significant effect on serum 25(OH)D levels [7]. Possible explanations for these contradictory results were attributed to unmeasured predictors of vitamin D status such as vitamin D intake and sun exposure [15].…”

Section: Discussionmentioning

confidence: 97%

“…Previously, few observational studies and randomized controlled trials reported conflicting results regarding the effect of statins on 25(OH)D concentrations. Some studies described higher 25(OH)D concentrations among statin users, whereas others did not [7][8][9][10][11][12][13][14][15]. Nevertheless, these studies were limited by small sample size, subjects with acute coronary syndrome, individual generic statins, diabetics hospitalized, and postmenopausal women with osteopenia [7,9,11,[14][15].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Statins on Serum Vitamin D Concentrations Among Older Adults

Orces¹,

Montalván²,

Tettamanti³

2020

Cureus

View full text Add to dashboard Cite

Background Randomized and observational studies have previously reported inconsistent results for the direct association between statin therapy and 25, hydroxyvitamin D [25(OH)D] levels. Thus, the present study aimed to examine the relationship between statin use and 25(OH)D and its metabolites concentrations in a large nationally representative sample of older adults. Methods This study was conducted using data from the National Health and Nutrition Examination Survey. Participants were asked to show the medication containers of all the products used in the previous 30 days, and the prescription of statins was defined on the three-level nested therapeutic classification scheme of Cerner Multum's Lexicon. General linear models adjusted for potential confounders were created to compare 25(OH)D concentrations between older adults taking statins and those who did not. Results A total of 6,261 participants with a mean age of 69.5 years comprised the study sample. Of those, 40.2% were taking statins with a median length of therapy of 5 years. Adjusted mean 25(OH)D 3 and 25(OH)D levels were 3.3 and 4.4 nmol/L higher among participants taking statins than those who did not, respectively. Moreover, this association was consistently seen regardless of the duration of therapy and particularly in subjects taking simvastatin, atorvastatin, or rosuvastatin. In subgroup analyses according to BMI categories and vitamin D intake, higher 25(OH)D levels were also seen among statin users. By contrast, this association was attenuated among those with a daily vitamin D between 400 and 800 and >800 IU. Conclusion Older adults on statin therapy had significantly higher serum 25(OH)D concentrations. Additional research should be conducted to define the mechanism of this association and determine if the pleiotropic effects attributed to statins may be mediated by vitamin D.

show abstract

Simvastatin treatment does not affect serum Vitamin D concentrations in patients with dyslipidemia: A randomized double-blind placebo-controlled cross-over trial

Cited by 12 publications

References 19 publications

Lack of association of statin use with Vitamin D levels in a hospital based population of type 2 diabetes mellitus patients

Lack of association of statin use with Vitamin D levels in a hospital based population of type 2 diabetes mellitus patients

Baseline Vitamin D Deficiency Decreases the Effectiveness of Statins in HIV-Infected Adults on Antiretroviral Therapy

The Effect of Statins on Serum Vitamin D Concentrations Among Older Adults

Contact Info

Product

Resources

About