Simvastatin May Improve Myocardial Perfusion Abnormality in Slow Coronary Flow

Cakmak, Mahmut; Tanrıverdi, Halil; Çakmak, Nazmiye; Evrengül, Harun; Cetemen, Sebnem; Kuru, Ömür

doi:10.1159/000109405

Cited by 37 publications

(35 citation statements)

References 46 publications

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“…In addition, Cakmak et al also demonstrated that simvastatin improved myocardial perfusion abnormality in patients with CSF [16]. Recently Ling et al have shown that statin therapy improved peripheral endothelial dysfunction in CSF patients [17]. Hinoi et al demonstrated the potent vasorelaxing effect of atorvastatin treatment on coronary microvessels in patients with normal epicardial coronary arteries [27].…”

Section: Discussionmentioning

confidence: 99%

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Relationship Between Angiographic Coronary Slow Flow Phenomenon and Subfoveal Choroidal Thickness: What is The Effect of Atorvastatin Therapy?

Kanar¹,

Kanar²

2018

Eur J Exp Bio

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Objective: Although the pathophysiological mechanisms underlying coronary slow flow (CSF) phenomenon still remains uncertain, the microvascular dysfunction has been first implicated. The CSF phenomenon may not only affect the coronary arteries but it may also be a part of vascular problem that affect other arteries. The aim of the present study is to evaluate the relationship between CSF phenomenon and subfoveal choroidal thickness (SFCT) and to investigate the effect of short-term atorvastatin therapy on SFCT in patients with CSF. Methods:The study population consisted of 48 patients with CSF and 41 healthy control participants. Coronary flow patterns of the patients were determined by thrombolysis in myocardial infarction (TIMI) frame count method. Spectral-domain optical coherence tomography (SD-OCT) measurements of SFCT and lipid parameters were obtained before and after 2 weeks of daily single dose of 80 mg atorvastatin therapy. Results:We found that patients with CSF had thinner SFCT compared with control group. There was a significant negative correlation between mean TIMI frame count and baseline SFCT (r=-0.69, p=0.001). ROC curve analysis revealed that SFCT <259 m predicted CSF with a 85% sensitivity and 88% specificity. The SFCT significantly increased after the short-term atorvastatin therapy. Conclusion:There was a close negative correlation between CSF phenomenon and SFCT. Endothelial dysfunction (ED) and the resultant microvascular dysfunction might be operative on both coronary and ocular choriocapillary arteries in patients with CSF. Increase of SFCT after the short-term atorvastatin therapy might be an indicator of microvascular dysfunction improvement in patients with CSF.

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Section: Discussionmentioning

confidence: 99%

“…plaques, decreasing oxidative stress and inflammation, and inhibiting the thrombogenic response [16]. Therefore, statins are suggested in the treatment of CSF syndrome [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Relationship Between Angiographic Coronary Slow Flow Phenomenon and Subfoveal Choroidal Thickness: What is The Effect of Atorvastatin Therapy?

Kanar¹,

Kanar²

2018

Eur J Exp Bio

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“…In a previous study, simvastatin was administered for 6 months to treat SCF patients [23]. Analysis using single photon emission computed tomography revealed a significant improvement in SCF, implying that simvastatin may exhibit statinslike multi-efficacy benefits in blood vessels and cardiomyocytes in addition to its hypolipidemic effects.…”

Section: Discussionmentioning

confidence: 98%

Effects of hyperbaric oxygen on vascular endothelial function in patients with slow coronary flow

Li¹,

Zhang

Liang

et al. 2018

Cardiol J.

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Background: To improve therapy for slow coronary flow (SCF), the effects of hyperbaric oxygen (HBO) therapy on vascular endothelial function in divided into two groups according to the following treatment: HBO group (n = 48) and the control group (n = 50). Patients in the control group were administrated with conventional treatment, while those in the HBO group were administrated HBO therapy for 4 weeks in addition to conventional treatment. To evaluate the effects of HBO on vascular endothelial functions, plasma levels of nitric oxide (NO), calcitonin gene-related peptide (CGRP), endothelin-1 (ET-1), high sensitivity C-reactive protein (hsCRP) as well as endothelial-dependent flowmediated vasodilation (FMD) of the brachial artery were measured in both groups before and after their respective treatments.Results: There were no significant differences in plasma levels of NO, CGRP, hsCRP (Cardiol J 2018; 25, 1: 106-112)

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“…Several studies concerning CSF have been performed to date [1,2,3,8,9,10,11]. On the basis of these studies we proposed that the CSF phenomenon should be considered as a ‘new disease entity’ [9].…”

Section: Discussionmentioning

confidence: 99%

Aortic Pressures, Stiffness and Left Ventricular Function in Coronary Slow Flow Phenomenon

et al. 2010

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Background: Coronary slow flow (CSF) phenomenon is characterized by delayed opacification of coronary vessels in a normal coronary angiogram. Although clinical and pathological features have been previously described, the underlying pathophysiology has not been fully elucidated. In this study, we aimed to evaluate central aortic pressure, aortic stiffness and left ventricular (LV) function in patients with coronary slow flow. Method and Results: The study population consisted of 154 patients who underwent coronary angiography because of typical and quasi-typical symptoms of angina. 81 patients with angiographically proven CSF and 73 cases with normal coronary flow pattern with similar risk profiles were enrolled in the study. Aortic pressures and indexes of elastic properties were evaluated using invasive methods. Aortic pulse pressure (mm Hg) and pulsality index of patients with CSF were found to be significantly higher than those of controls (60.8 ± 13.8 vs. 53.7 ± 14.5, p = 0.002; 0.84 ± 0.22 vs. 0.67 ± 0.18, p = 0.0001, respectively). LV Doppler parameters were deteriorated in patients with CSF. Aortic fractional pulse pressure and pulsality index were significantly correlated with the mean TIMI frame count and LV diastolic parameters in correlation analysis. Conclusion: The present findings allow us to conclude that impaired aortic elasticity in patients with CSF may also be responsible for the impaired LV diastolic parameters.

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Simvastatin May Improve Myocardial Perfusion Abnormality in Slow Coronary Flow

Cited by 37 publications

References 46 publications

Relationship Between Angiographic Coronary Slow Flow Phenomenon and Subfoveal Choroidal Thickness: What is The Effect of Atorvastatin Therapy?

Relationship Between Angiographic Coronary Slow Flow Phenomenon and Subfoveal Choroidal Thickness: What is The Effect of Atorvastatin Therapy?

Effects of hyperbaric oxygen on vascular endothelial function in patients with slow coronary flow

Aortic Pressures, Stiffness and Left Ventricular Function in Coronary Slow Flow Phenomenon

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