Simvastatin-Loaded Nanofibrous Membrane Efficiency on the Repair of Achilles Tendons

Weng, Chun-Jui; Liao, Chieh-Tun; Hsu, Ming-Yi; Chang, Fu; Liu, Shih‐Jung

doi:10.2147/ijn.s353066

Cited by 7 publications

(3 citation statements)

References 51 publications

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“…In animal models, the biomechanical properties of decellularized tendon grafts can be enhanced by applying periodic mechanical stimulation ( Klifto et al, 2018 ). In addition, the nanofibers prepared by electrospinning have controllable diameter, orderly arrangement, high porosity, and a large specific surface area, which are usually easy to meet the requirements of tissue engineering for tendon repair, with a low production cost and high efficiency, which makes them ideal for tendon injury treatment ( Li et al, 2022 ; Weng et al, 2022 ). By optimizing the design and fabrication methods, electro spun 3D scaffolds can function in the three phases of inflammation, proliferation, and remodeling after tendon injury ( Y et al, 2023 ).…”

Section: Strategies To Promote Tendon Healingmentioning

confidence: 99%

Advances in non-coding RNA in tendon injuries

Wang,

Chen,

Zou

et al. 2024

Front. Genet.

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Tendons serve as important weight-bearing structures that smoothly transfer forces from muscles to skeletal parts, allowing contracted muscle movements to be translated into corresponding joint movements. For body mechanics, tendon tissue plays an important role. If the tendons are damaged to varying degrees, it can lead to disability or pain in patients. That is to say, tendon injuries havea significant impact on quality of life and deserve our high attention. Compared to other musculoskeletal tissues, tendons are hypovascular and hypo-cellular, and therefore have a greater ability to heal, this will lead to a longer recovery period after injury or even disability, which will significantly affect the quality of life. There are many causes of tendon injury, including trauma, genetic factors, inflammation, aging, and long-term overuse, and the study of related mechanisms is of great significance. Currently, tendon there are different treatment modalities, like injection therapy and surgical interventions. However, they have a high failure rate due to different reasons, among which the formation of adhesions severely weakens the tissue strength, affecting the functional recovery and the patient’s quality of life. A large amount of data has shown that non coding RNAs can play a huge role in this field, thus attracting widespread attention from researchers from various countries. This review summarizes the relevant research progress on non-coding RNAs in tendon injuries, providing new ideas for a deeper understanding of tendon injuries and exploring new diagnostic and therapeutic approaches.

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Section: Strategies To Promote Tendon Healingmentioning

confidence: 99%

Advances in non-coding RNA in tendon injuries

Wang,

Chen,

Zou

et al. 2024

Front. Genet.

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“…Chemically manufactured or naturally occurring small molecules, on the other hand, provide numerous advantages over growth factors in regulating cell behavior, including quantity control, cell permeability, cost efficiency, and time efficiency ( Zhang C. et al, 2018 ). MLT ( Yao et al, 2022 ), RGD ( Yin et al, 2020 ), and simvastatin ( Weng et al, 2022 )-loaded nanofiber scaffolds have been proven to enhance AT regeneration in vitro and in vivo .…”

Section: Tissue Regeneration Strategies For Achilles Tendon Injury Tr...mentioning

confidence: 99%

Advanced Nanofiber-Based Scaffolds for Achilles Tendon Regenerative Engineering

Zhu

He²,

Ji³

et al. 2022

Front. Bioeng. Biotechnol.

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The Achilles tendon (AT) is responsible for running, jumping, and standing. The AT injuries are very common in the population. In the adult population (21–60 years), the incidence of AT injuries is approximately 2.35 per 1,000 people. It negatively impacts people’s quality of life and increases the medical burden. Due to its low cellularity and vascular deficiency, AT has a poor healing ability. Therefore, AT injury healing has attracted a lot of attention from researchers. Current AT injury treatment options cannot effectively restore the mechanical structure and function of AT, which promotes the development of AT regenerative tissue engineering. Various nanofiber-based scaffolds are currently being explored due to their structural similarity to natural tendon and their ability to promote tissue regeneration. This review discusses current methods of AT regeneration, recent advances in the fabrication and enhancement of nanofiber-based scaffolds, and the development and use of multiscale nanofiber-based scaffolds for AT regeneration.

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“…[1][2][3][4] Over the past several decades, various modalities have been investigated for enhancing tendon healing and reducing adhesion formation. [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] However, optimal regimens have not been determined. [1][2][3][4] Verapamil, a calcium channel blocker, effectively reduces hypertrophic scars through the topical application without adverse effects.…”

Section: Introductionmentioning

confidence: 99%

Combined Verapamil-Polydopamine Nanoformulation Inhibits Adhesion Formation in Achilles Tendon Injury Using Rat Model

Gong

Zhou

et al. 2023

IJN

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Introduction Topical verapamil has been demonstrated to reduce the fibroproliferative scar. Therefore, it was hypothesized that topical verapamil could reduce adhesion formation after tendon repair. The current study aimed to examine the effects of verapamil-loaded polydopamine nanoparticles (VP-PDA NPs) on the adhesion formation of Achilles tendon laceration and repair in a rat model. Methods We randomly assigned 72 male Sprague-Dawley rats to the control, the PDA NPs, and the VP-PDA NPs groups (n = 24 per group). The quality of tendon healing was evaluated by the maximal tensile strength four and six weeks after surgery. The degree of tendon adhesion was scored on days 4, 15, 29, and 43 after surgery. The expressions of transforming growth factor-beta 1 (TGF-β1), vimentin, α-smooth muscle actin (α-SMA), and collagens type I and III were detected through Western blotting or immunohistochemistry at four weeks after surgery. Results In vitro release tests revealed that 61.3% of verapamil was released from VP-PDA NPs in four weeks. There was a significant increase in average failure to load in the VP-PDA NPs group (89.27 ± 5.09 N) compared with the PDA NPs group (65.52 ± 2.04 N) (p = 0.003) and the control group (74.52 ± 4.24 N) (p = 0.029). Adhesion scores were significantly reduced in the VP-PDA NPs group at six weeks (3.175 ± 0.08) and four weeks (3.35 ± 0.25) compared with the other groups. Moreover, VP-PDA NPs significantly reduced the expression of vimentin, α-SMA, TGF-β1, and collagens type I and III. Conclusion These data suggest that VP-PDA NPs reduced adhesion formation and enhanced tendon healing during rat tendon injury. Since topical verapamil has been used in clinics without side effects, VP-PDA NPs would have direct translation implications. However, its anti-adhesive effects on intrasynovial tendon injury must be examined.

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Simvastatin-Loaded Nanofibrous Membrane Efficiency on the Repair of Achilles Tendons

Cited by 7 publications

References 51 publications

Advances in non-coding RNA in tendon injuries

Advances in non-coding RNA in tendon injuries

Advanced Nanofiber-Based Scaffolds for Achilles Tendon Regenerative Engineering

Combined Verapamil-Polydopamine Nanoformulation Inhibits Adhesion Formation in Achilles Tendon Injury Using Rat Model

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