volume 31, issue 5, P300-307 2016
DOI: 10.1590/s0102-865020160050000002
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Abstract: ABSTRACT PURPOSE:To investigate the effects of locally applied simvastatin plus biphasic calcium phosphate (BoneCeramic ® ) or collagen sponge on bone formation in critical-sized bone defects. METHODS:Thirty defects of 5mm in diameter were created bilaterally with a trephine bur in the calvariae of fifteen Wistar rats. The defects were divided into five groups: group 1 -control, no treatment; group 2 (BoneCeramic ® ); group 3 (BoneCeramic ® + 0.1mg simvastatin); group 4 (collagen sponge); and group 5 (collage…

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