Simvastatin and Bezafibrate ameliorate Emotional disorder Induced by High fat diet in C57BL/6 mice

Abstract

High fat diet (HFD)-induced metabolic disorders may lead to emotional disorders. This study aimed to explore the effect of simvastatin (SMV) and bezafibrate (BZ) on improving HFD-induced emotional changes, and tried to identify their different mechanisms. The intraperitoneal glucose tolerance test (IPGTT) was used to evaluate glucose control ability; and behavior tests including open field tests (OFT), forced swimming tests (FST), tail suspension tests (TST) and sucrose preference (SPT), were then performed to evaluate emotional changes. Serum samples were collected for the LC-MS based metabolomics analysis to explore the emotional-related differential compounds; we then evaluated the effect of the drugs. The abnormal serum metabolic profiling and emotional changes caused by HFD in mice was alleviated by SMV treatment, whereas BZ only affected the emotional disorder. The improvement of cannabinoid analogues and then produced influences on the endocannabinoid system, which may be a potential mechanism SMV action. BZ promoted tryptophan-serotonin pathway and inhibited tryptophan-kynurenine pathway, which may be its mechanism of action. Here, we proposed a shed light on the biological mechanisms underlying the observed effects, and identified an important drug candidate for the treatment of emotional disorders induced by HFD.

Alteration of gut microbiota induced by DPP-4i treatment improves glucose homeostasis

“…1a). The HFD and ND groups also formed different clusters, which is consistent with previous reports [17,37]. Moreover, hierarchical clustering of the heatmap revealed striking changes in the genera resulting in distinct clustering of the samples (Fig.…”

Low Dietary Fish Meal Induced Endoplasmic Reticulum Stress and Impaired Phospholipids Metabolism in Juvenile Pacific White Shrimp, Litopenaeus vannamei

“…Some research showed that LPC and LPE are increased in inflammation associated diseases, and they exert their effects through different signaling pathways such as PKC, NF-κB and ERK (Zeng et al, 2017). While in other studies, some of the LPC and LPE were decreased in the inflammation condition (Bai et al, 2014;Zhou et al, 2014;Qian et al, 2017;Wang et al, 2017). In this study, several LPC and LPE were decreased with the decreasing dietary FM levels, which indicated the relationship of inflammation and the levels of LPC and LPE may dependent on species and the inflammation stage.…”

Diet-Derived Fatty Acids, Brain Inflammation, and Mental Health

“…Patients presenting mood disorders show elevated plasma levels of cytokines such as TNF-α, IL-6, and IL-1β, as well as increased expression of inflammatory markers in blood cells (reviewed by Mechawar and Savitz, 2016). Increased consumption of high fat diet is related to depressive-like behavior and emotional disorders in mice (Wang et al, 2017; Arcego et al, 2018; Vagena et al, 2018; Xu et al, 2018), and neuroinflammation could be an important modulator of these behavioral alterations. Palmitic acid abolished the migration and phagocytic activity of microglia in response to interferon-γ, thus affecting the protective response of these cells after an inflammatory challenge in vitro (Yanguas-Casás et al, 2018).…”