Simvastatin alleviated diabetes mellitus‐induced erectile dysfunction in rats by enhancing AMPK pathway‐induced autophagy

Fan, Hang; Shan, Changyu; Li, Hongwei; Zhang, Yuping; Guo, Chunling; Zhou, Zhansong; Zheng, Jing; Shen, Wenhao; Dai, Qiang; Ouyang, Qin; Wu, Xiaojun

doi:10.1111/andr.12758

Cited by 19 publications

(14 citation statements)

References 61 publications

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“…Recent studies have shown that simvastatin lead to cell-cycle arrest via AMPK activation and STAT3/SKP2 axis inhibition [ 41 , 74 ]. Ding et al demonstrated that simvastatin could activate the AMPK-SKP2-CARM1 pathway, upregulate protective autophagy, and inhibit corpus cavernosum fibrosis and improved erectile function in diabetes-induced erectile dysfunction rats [ 75 ].…”

Section: Ampk-associated Therapeutic Effects Of Statinsmentioning

confidence: 99%

Targeting AMPK by Statins: A Potential Therapeutic Approach

Dehnavi

Kiani

Sadeghi

et al. 2021

Drugs

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Statins are a group of lipid-lowering drugs that inhibit cholesterol biosynthesis and have anti-inflammatory, anti-tumor, and immunomodulatory properties. Several lines of evidence indicate that statins regulate multiple proteins associated with the regulation of differing cellular pathways. The 5′-adenosine monophosphate-activated protein kinase (AMPK) pathway plays an important role in metabolism homeostasis with effects on cellular processes including apoptosis and the inflammatory responses through several pathways. Recently, it has been shown that statins can affect the AMPK pathway in differing physiological and pathological ways, resulting in anti-cancer, cardio-protective, neuro-protective, and anti-tubercular effects; additionally, they have therapeutic effects on non-alcoholic fatty liver disease and diabetes mellitus-associated complications. Statins activate AMPK as an energy sensor that inhibits cell proliferation and induces apoptosis in cancer cells, whilst exerting its cardio-protective effects through inhibition of inflammation and fibrosis, and promotion of angiogenesis. Furthermore, statin-associated AMPK activation leads to decreased lipid accumulation and decreased amyloid beta deposition in the liver and brain, respectively, and may have therapeutic effects on the liver and neurons. In this review, we summarize the results of studies of AMPK-associated therapeutic effects of statins in different pathological conditions.

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Section: Ampk-associated Therapeutic Effects Of Statinsmentioning

confidence: 99%

Targeting AMPK by Statins: A Potential Therapeutic Approach

Dehnavi

Kiani

Sadeghi

et al. 2021

Drugs

View full text Add to dashboard Cite

show abstract

“…In the recent few years, the role of autophagy in diseases have been widely explored, including cardiovascular diseases February 2021 | Volume 12 | Article 621132 such as myocardial infarction (Liu et al, 2020;Shi et al, 2020) and atherosclerosis (Wang et al, 2019;Cao et al, 2020), neurodegenerative disorders like multiple sclerosis (Shao et al, 2017;Andhavarapu et al, 2019), metabolic diseases including diabetes (Marasco and Linnemann, 2018;Ding et al, 2020) and obesity (Bartelt and Widenmaier, 2020) and inflammatory and immunerelated disorders such as IBD (Dalmasso et al, 2019;Tan et al, 2019;Sola Tapias et al, 2020), and arthritis (Vomero et al, 2018). Although the inflammatory and immune suppressive effect of autophagy has been revealed, some researchers also identified autophagy as a form of cellular death.…”

Section: Biological Characteristics Of Autophagymentioning

confidence: 99%

The Role of Autophagy in Inflammatory Bowel Disease

et al. 2021

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Inflammatory bowel disease (IBD) is an idiopathic intestinal inflammatory disease, including ulcerative colitis (UC) and Crohn’s disease (CD). The abnormality of inflammatory and immune responses in the intestine contributes to the pathogenesis and progression of IBD. Autophagy is a vital catabolic process in cells. Recent studies report that autophagy is highly involved in various kinds of diseases, especially inflammation-related diseases, such as IBD. In this review, the biological characteristics of autophagy and its role in IBD will be described and discussed based on recent literature. In addition, several therapies for IBD through modulating the inflammasome and intestinal microbiota taking advantage of autophagy regulation will be introduced. We aim to bring new insight in the exploration of mechanisms for IBD and development of novel therapeutic strategies against IBD.

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“…In a rat model of hyperlipidemia and ED, dietary changes were linked to positive effects on penile hemodynamics [143]. Chronic statin treatment, through its anti-oxidative effects on the endothelium, seems effective in restoring erectile function in diabetic rats [144,145].…”

Section: From CV Risk Identification To Cv Risk Modificationmentioning

confidence: 99%

Erectile Dysfunction Is a Hallmark of Cardiovascular Disease: Unavoidable Matter of Fact or Opportunity to Improve Men’s Health?

Frizza

Vignozzi

Corona

et al. 2021

JCM

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Erectile dysfunction (ED) is an early manifestation of cardiovascular (CV) disease. For this reason, men with ED should be carefully assessed for CV risk factors in order to prevent future major adverse CV events (MACE). Traditional risk factors are not found in all subjects at high CV risk. In fact, a relevant proportion of MACE occurs in men who are apparently risk factor free. In men with ED, it is important to take into account not only traditional risk factors but also unconventional ones. Several parameters that derive from good clinical assessment of subjects with ED have proven to be valuable predictors of MACE. These include family history of cardiometabolic events, alcohol abuse, fatherhood, decreased partner’s sexual interest, severe impairment in erection during intercourse or during masturbation, impaired fasting glucose, increased triglycerides, obesity even without metabolic complications, decreased penile blood flows or impaired response to an intra-cavernosal injection test. Recognizing these risk factors may help in identifying, among subjects with ED, those who merit stricter lifestyle or pharmacological interventions to minimize their CV risk. Effective correction of risk factors in ED men considered as high risk, besides reducing CV risk, is also able to improve erectile function.

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Simvastatin alleviated diabetes mellitus‐induced erectile dysfunction in rats by enhancing AMPK pathway‐induced autophagy

Cited by 19 publications

References 61 publications

Targeting AMPK by Statins: A Potential Therapeutic Approach

Targeting AMPK by Statins: A Potential Therapeutic Approach

The Role of Autophagy in Inflammatory Bowel Disease

Erectile Dysfunction Is a Hallmark of Cardiovascular Disease: Unavoidable Matter of Fact or Opportunity to Improve Men’s Health?

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