Simultaneously intensified plasmonic and charge transfer effects in surface enhanced Raman scattering sensors using an MXene-blanketed Au nanoparticle assembly

Yoo, Seong Soo; Ho, Jeongwon; Shin, Dong-In; Kim, Minjun; Hong, Seung Hyun; Lee, Jun Hyuk; Jeong, Hyobin; Jeong, Mun Seok; Yi, Gi‐Ra; Kwon, Seok Joon; Yoo, Pil J.

doi:10.1039/d1ta08918h

Cited by 20 publications

(11 citation statements)

References 46 publications

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“…First, Au@Ag NPs were self-assembled using the liquid−liquid method. 39 Simply, 3 mL of the synthesized Au@Ag NPs solution and 3 mL of cyclohexane were added into a beaker and formed an immiscible interface. Then, anhydrous ethanol was injected below the immiscible interface gently until a film formed.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

Dual-Aptamer-Assisted Ratiometric SERS Biosensor for Ultrasensitive and Precise Identification of Breast Cancer Exosomes

Zhang

et al. 2023

ACS Sens.

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Due to the heterogeneity of breast cancer, its early accurate diagnosis remains a challenge. Exosomes carry abundant genetic materials and proteins and are ideal biomarkers for early cancer detection. Herein, a ratiometric surface-enhanced Raman scattering (SERS) biosensor for exosome detection was constructed using a regularly arranged Au@Ag nanoparticles/graphene oxide (Au@Ag NPs/GO) substrate with 4nitrothiophenol (4-NTP) molecules as an internal standard. Aptamers of two overexpressed proteins (epithelial cell adhesion molecule and human epidermal growth factor receptor 2) were linked by a short complementary DNA with rhodamine X modified at the 3′-terminal to form V-shaped double-stranded DNA, which attached to the surface of Au@Ag NPs/GO substrate for the selective recognition of breast cancer cell-derived exosomes. In the presence of exosomes, a competitive reaction occurred, resulting in the formation of the V-shaped double-stranded DNA/exosomes complex, and the V-shaped double-stranded DNA separated from the SERS substrate. The SERS signal of rhodamine X on the V-shaped double-stranded DNA decreased with the concentration of exosomes increasing, whereas the SERS signal of 4-NTP on the substrate remained stable. The ratiometric SERS strategy provides huge electromagnetic enhancement and abundant DNA adsorbing sites on the GO layer, achieving a wide detection range of 2.7 × 10 2 to 2.7 × 10 8 particles/mL and an ultralow limit of detection down to 1.5 × 10 2 particles/mL, without the requirement of any nucleic acid amplification. Particularly, the proposed method has significant applications in early cancer diagnosis as it can accurately identify breast cancer cell-derived exosomes in clinical serum samples and can differentiate pancreatic cancer patients and healthy individuals.

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Section: ■ Experimental Sectionmentioning

confidence: 99%

Dual-Aptamer-Assisted Ratiometric SERS Biosensor for Ultrasensitive and Precise Identification of Breast Cancer Exosomes

Zhang

et al. 2023

ACS Sens.

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“…The pleated surface structure generated by the conformal covering of the MXene layer on the metal nanoparticles module helps to increase the electromagnetic effect by guiding the analyte to be captured near the hot spot center between Au NPs (Figure 1c). [37] Therefore, introducing MXene into SERS substrate can promote SERS enhancement through chemical enhancement and electromagnetic enhancement. Peng et al.…”

Section: Type Of Sers Substratementioning

confidence: 99%

Application of SERS in In‐Vitro Biomedical Detection

Chen

Teng

et al. 2023

Chemistry An Asian Journal

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Surface-enhanced Raman scattering (SERS), as a rapid and nondestructive biological detection method, holds great promise for clinical on spot and early diagnosis. In order to address the challenging demands of on spot detection of biomedical samples, a variety of strategies has been developed. These strategies include substrate structural and component engineering, data processing techniques, as well as combination with other analytical methods. This report summarizes the recent SERS developments for biomedical detection, and their promising applications in cancer detection, virus or bacterial infection detection, miscarriage spotting, neurological disease screening et al. The first part discusses the frequently used SERS substrate component and structures, the second part reports on the detection strategies for nucleic acids, proteins, bacteria, and virus, the third part summarizes their promising applications in clinical detection in a variety of illnesses, and the forth part reports on recent development of SERS in combination with other analytical techniques. The special merits, challenges, and perspectives are discussed in both introduction and conclusion sections.

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“…Again, a strong long-range SERS enhancement was observed with several characteristic peaks of R6G. The SERS enhancement factor of R6G by the HyCoS AuPd NPs was ~10 9 as calculated in Table S2 , indicating the strong SERS effect by the HyCoS plasmonic template through the electromagnetic mechanism (EM) enhancement by the strong hotspots and electromagnetic fields through LSPR [ 7 , 41 ]. Subsequently, the volume ratio of 2:1 mixture solution of MoS 2 and 10 −6 M R6G in total 20 µL was applied on the plasmonic HyCoS AuPd NP template in Figure 4 (a-4).…”

Section: Sers Analyses Of Rhodamine 6g On Various Substratesmentioning

confidence: 99%

“…Obviously, the SERS counts can be increased with the increased molar concentration of R6G, which shows that the HyCoS AuPd NP is an effective SERS substrate. The prepared plasmonic template can sensitively detect the R6G molecules down to 10 −8 M. Generally, the SERS enhancement by the metallic NP substrate is known as electromagnetic mechanism (EM) enhancement [ 7 , 41 ].…”

Section: Sers Analyses Of Rhodamine 6g On Various Substratesmentioning

confidence: 99%

MoS2 Nanoplatelets on Hybrid Core-Shell (HyCoS) AuPd NPs for Hybrid SERS Platform for Detection of R6G

et al. 2023

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In this work, a novel hybrid SERS platform incorporating hybrid core-shell (HyCoS) AuPd nanoparticles (NPs) and MoS2 nanoplatelets has been successfully demonstrated for strong surface-enhanced Raman spectroscopy (SERS) enhancement of Rhodamine 6G (R6G). A significantly improved SERS signal of R6G is observed on the hybrid SERS platform by adapting both electromagnetic mechanism (EM) and chemical mechanism (CM) in a single platform. The EM enhancement originates from the unique plasmonic HyCoS AuPd NP template fabricated by the modified droplet epitaxy, which exhibits strong plasmon excitation of hotspots at the nanogaps of metallic NPs and abundant generation of electric fields by localized surface plasmon resonance (LSPR). Superior LSPR results from the coupling of distinctive AuPd core-shell NP and high-density background Au NPs. The CM enhancement is associated with the charge transfer from the MoS2 nanoplatelets to the R6G. The direct contact via mixing approach with optimal mixing ratio can effectively facilitate the charges transfer to the HOMO and LUMO of R6G, leading to the orders of Raman signal amplification. The enhancement factor (EF) for the proposed hybrid platform reaches ~1010 for R6G on the hybrid SERS platform.

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Simultaneously intensified plasmonic and charge transfer effects in surface enhanced Raman scattering sensors using an MXene-blanketed Au nanoparticle assembly

Abstract: Surface enhanced Raman spectroscopy (SERS) is an ultrasensitive tool for detecting wide range of analytes. The signal amplification is generally attributed by two different mechanisms of localized surface plasmonic resonance...

Cited by 20 publications

References 46 publications

Dual-Aptamer-Assisted Ratiometric SERS Biosensor for Ultrasensitive and Precise Identification of Breast Cancer Exosomes

Dual-Aptamer-Assisted Ratiometric SERS Biosensor for Ultrasensitive and Precise Identification of Breast Cancer Exosomes

Application of SERS in In‐Vitro Biomedical Detection

MoS2 Nanoplatelets on Hybrid Core-Shell (HyCoS) AuPd NPs for Hybrid SERS Platform for Detection of R6G

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