Simultaneously Detected Endometrial and Ovarian Carcinomas— A Prospective Clinicopathologic Study of 74 Cases: A Gynecologic Oncology Group Study

Zaino, Richard J.; Whitney, Charles W.; Brady, Mark F.; DeGeest, Koen; Burger, Robert A.; Buller, Richard E.

doi:10.1006/gyno.2001.6400

Cited by 282 publications

(281 citation statements)

References 15 publications

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“…Most commonly, the adenocarcinomas are endometrioid in type but sometimes they are serous. 147,148 With endometrioid adenocarcinomas involving the uterus and one or both ovaries, immunohistochemistry is of little or no value in ascertaining the relationship between the tumours as the immunophenotype of a primary ovarian and uterine endometrioid adenocarcinoma is essentially identical.…”

Section: Distinction Between Ovarian and Uterine Carcinomamentioning

confidence: 99%

Data set for reporting of ovary, fallopian tube and primary peritoneal carcinoma: recommendations from the International Collaboration on Cancer Reporting (ICCR)

et al. 2015

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Section: Distinction Between Ovarian and Uterine Carcinomamentioning

confidence: 99%

Data set for reporting of ovary, fallopian tube and primary peritoneal carcinoma: recommendations from the International Collaboration on Cancer Reporting (ICCR)

et al. 2015

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“…Clear-cell and endometrioid carcinomas are the commonest EAOCs with ovarian endometriosis, while clear-cell adenocarcinoma and adenosarcoma are the commonest EAOCs in extra-ovarian endometriosis (Erzen & Kovacic 1998, Stern et al 2001, Zaino et al 2001. The risk of direct malignant transformation of ovarian endometriosis has been estimated as 0.7 -1.6% over an average of 8 years (Seidman 1996.…”

Section: Ovarian Malignancy May Arise Directly From Ovarian Endometrimentioning

confidence: 99%

“…Increased risk of synchronous endometrial and ovarian cancers, especially endometrioid type, in the presence of endometriosis Simultaneously detected endometrial and ovarian carcinomas are most often associated with endometrioid subtypes, and ovarian endometriosis was identified in around 30% of these cases (Erzen & Kovacic 1998, Stern et al 2001, Zaino et al 2001.…”

Section: Ovarian Malignancy May Arise Directly From Ovarian Endometrimentioning

confidence: 99%

Endometriosis and the neoplastic process

Varma¹,

Rollason²,

Gupta³

et al. 2004

Reproduction

184

146

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Endometriosis is a frequent disorder that commonly presents with infertility and pelvic pain. Although the precise aetiology of endometriosis is unclear, it is generally considered to involve multiple genetic, environmental, immunological, angiogenic and endocrine processes. Genetic factors have been implicated in endometriosis but the susceptibility genes remain largely unknown. Although endometriosis is a benign disorder, recent studies of endometriosis suggest endometriosis could be viewed as a neoplastic process. Evidence to support this hypothesis includes the increased susceptibility to develop ovarian clear-cell and endometrioid cancers in the presence of endometriosis, and molecular similarities between endometriosis and cancer. In this article we discuss (i) the evidence suggesting that endometriosis might be viewed as a neoplastic process, and (ii) the implications of this hypothesis for elucidating the pathogenesis of endometriosis and developing novel methods of diagnostic classification and individualised treatments.

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“…It is being thought that severe military conflicts in Africa shorten the expected lifetime for more than 2 years. In general, WHO had calculated that 269 thousand people had died in 1999 due to the effect of wars and that loss of 8.44 million healthy years of life had occurred (2,3). Wars negatively affect the provision of health services.…”

Section: War and Women's Healthmentioning

confidence: 99%

“…Moreover, the wars cause the migration of qualified health employees, and thus the health services hitches. Assessments made indicate that the effect of destruction in the infrastructure of health continues for 5-10 years even after the finalization of conflicts (3). Due to resource requirements in the restructuring investments after war, the share allocated to health has decreased (1).…”

Section: War and Women's Healthmentioning

confidence: 99%

Synchronous Endometrial and Ovarian Cancer With Sigmoid Colon Metastasis One Year After Primary Surgery: A Case Report

Güzin¹,

Balcı²,

Sandal³

et al. 2015

IJWHR

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IntroductionThe presence of synchronous primary malignancies in the female genital tract is relatively rare. Primary tumors in two organs within a single person is called synchronous primary malignancies. The two types of synchronous cancers commonly reported have been ovarian cancer and endometrial cancer (1,2). Synchronous primary tumor of the endometrium and ovary occur in up to 10% of all ovarian cancer cases and 5% of all endometrial cancer cases (3). Patients with simultaneous uterine and ovarian cancers do generally show a better prognosis than those with metastatic disease. (2,4-6). We describe herein, a patient whose disease was not consistent with this data, she had ovarian cancer (stage 1A) and endometrial cancer (stage 1A) which metastasized to sigmoid colon one year after surgery. Case PresentationA 53-year-old postmenopausal women, with a history of 5 pregnancies, 2 deliveries, 1 dilatation and curettage and 2 missed abortus, admitted to our clinic with the complaints of abdominal pain, abdominal distension and postmenopausal bleeding. Her family and previous disease histories were unremarkable. Her physical examination and transvaginal ultrasound scan revealed free fluid in the abdominal cavity and a cystic mass containing papillary projections with the dimensions of 6.5 × 5 × 4 cm on the right ovary. Tumor marker (carbohydrate antigen) (CA) 125 was elevated, 223 IU. The dilatation and curettage was performed and the histopathological diagnosis of endometrial curettage was endometrioid adenocarcinoma. Computed tomography revealed no metastasis. Under the diagnosis of endometrial cancer and probably ovarian cancer; malignant ascites sampling, radical hysterectomy, bilateral salpingo-oophorectomy, pelvic and paraaortic lymphadenectomy, omentectomy, appendectomy and cytologic sampling of the undersurface of the diaphragm were carried out (tumor free). Histopathological diagnosis of endometrial cancer was grade 2 adenocarcinoma with squamous differentiation (stage 1A) with less than Abstract Introduction: We describe a patient who had ovarian and endometrial cancer which metastasized to sigmoid colon one year after surgery. Case Presentation: A 53-year-old woman was admitted with the complaints of abdominal pain, abdominal distension and postmenopausal bleeding. Her transvaginal ultrasound scan revealed a cystic mass containing papillary projections with the dimensions of 6.5 × 5 × 4 cm on the right ovary. Level of (carbohydrate antigen) (CA) 125 was 223 IU. Dilation and curettage revealed endometrioid adenocarcinoma. Debulking surgerywas carried out. Histopathological diagnosis was grade 2 adenocarcinoma with squamous differentiation for endometrial cancer and grade 2 endometrioid adenocarcinoma with squamous and mucinous differentiation for ovarian cancer. The stage was 1A for endometrial cancer and 1A for ovarian cancer. 12 months after the operation CA 125 level was 112 IU. Positron emission tomography (PET) scan showed a small lesion (1.5×1.5 cm) in the pelvic cavity with increased fluorodeoxyglu...

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Simultaneously Detected Endometrial and Ovarian Carcinomas— A Prospective Clinicopathologic Study of 74 Cases: A Gynecologic Oncology Group Study

Cited by 282 publications

References 15 publications

Data set for reporting of ovary, fallopian tube and primary peritoneal carcinoma: recommendations from the International Collaboration on Cancer Reporting (ICCR)

Data set for reporting of ovary, fallopian tube and primary peritoneal carcinoma: recommendations from the International Collaboration on Cancer Reporting (ICCR)

Endometriosis and the neoplastic process

Synchronous Endometrial and Ovarian Cancer With Sigmoid Colon Metastasis One Year After Primary Surgery: A Case Report

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