1982
DOI: 10.1177/30.8.7119422
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Simultaneous ultrastructural localization of tritiated serotonin and immunoreactive peptides.

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Cited by 19 publications
(3 citation statements)
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“…This is particularly true for the RMc neurons, which we previously demonstrated target the dorsal horn (Basbaum et al, 1978). Our results suggest, therefore, that RVM serotonergic neurons influence spinal cord nociceptive processing both directly, via a 5HT projection to the dorsal horn (Basbaum et al, 1982;VanderHorst and Ulfhake, 2006) and indirectly, via a polysynaptic pathway involving the spinally projecting, non-5HT cell populations. To what extent the latter control circuit arises from "on" and "off" cells cannot be determined from our analysis; however, Potrebic et al (1995) reported that 5HT neurons and "off" cells receive the highest density of 5HT appositions.…”
Section: Local Connections Made By Serotonergic Neurons In the Medullmentioning
confidence: 66%
“…This is particularly true for the RMc neurons, which we previously demonstrated target the dorsal horn (Basbaum et al, 1978). Our results suggest, therefore, that RVM serotonergic neurons influence spinal cord nociceptive processing both directly, via a 5HT projection to the dorsal horn (Basbaum et al, 1982;VanderHorst and Ulfhake, 2006) and indirectly, via a polysynaptic pathway involving the spinally projecting, non-5HT cell populations. To what extent the latter control circuit arises from "on" and "off" cells cannot be determined from our analysis; however, Potrebic et al (1995) reported that 5HT neurons and "off" cells receive the highest density of 5HT appositions.…”
Section: Local Connections Made By Serotonergic Neurons In the Medullmentioning
confidence: 66%
“…These are reminiscent of the marginal and stalked cells found in the spinal cord to receive an abundant 5-HT axodendritic innervation (Miletic et al, 1984). Double-labeling studies using tritiated 5-HT autoradiography combined with ENK immunocytochemistry confirmed a 5-HT to ENK linkage onto precisely these kinds of cells in laminae I and I1 (Basbaum et al, 1982).…”
Section: Discussionmentioning
confidence: 77%
“…The nucleus raphe magnus and related reticular nuclei have been shown to have serotoninergic, enkephalinergic, and other peptidergic projections to those brainstem and spinal cord nuclei that relay nociceptive inputs from the periphery (Basbaum and Fields, 1984;Basbaum et al, 1978Basbaum et al, , 1982Dostrovsky et al, 1982Dostrovsky et al, , 1983Dubner and Bennett, 1983;Dubner et al, 1984;Menetrey and Basbaum, 1987;Millan, 1986;Willis, 1982Willis, , 1984Willis, , 1985a. The medullary (Vc) and spinal dorsal horns have received the most attention.…”
Section: Introductionmentioning
confidence: 99%