“…In mathematical programming, HENs retrofit is considered as an optimization problem, comprising the field with the highest advances due to its ability to obtain better solutions. Yee and Grossmann [23] presented a mathematical approach to Clearly, it is possible to integrate heat and work in the same network in order to save energy and reduce process costs as indicated in the references [28,29,31,32,37]. Doubtless, this concept can be extended to the retrofit problem of existing HENs with significant advantages.…”