Simultaneous surface functionalization and drug loading: A novel method for fabrication of cellulose nanocrystals-based pH responsive drug delivery system

Long, Wei; Ouyang, Hui; Zhou, Chaoqun; Wan, Weimin; Yu, Shengxian; Qian, Kai; Zhang, Xiaoyong; Feng, Yulin; Wei, Yen

doi:10.1016/j.ijbiomac.2021.05.193

Cited by 22 publications

(6 citation statements)

References 48 publications

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“…The sensitivity of the hydrazone bond to the acidic environment has since been deeply and extensively studied, and it has been applied to various structures, including linear ( 73 ), star-shaped ( 74 ), and cross-linked ( 75 ) molecules. Recently, Long et al ( 76 ) reported a novel strategy to endow cellulose nanocrystals (CNCs) with pH responsiveness and drug loading through the formation of hydrazone bonds between PEG-modified CNCs and the aldehyde group of DOX. DOX was loaded on PEG-modified CNCs and could be specifically released from pH-responsive drug polymer carriers at the tumor site.…”

Section: Mechanism Of Ph-responsive Polymer Nanomaterials In Tumor Th...mentioning

confidence: 99%

pH-Responsive Polymer Nanomaterials for Tumor Therapy

et al. 2022

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The complexity of the tumor microenvironment presents significant challenges to cancer therapy, while providing opportunities for targeted drug delivery. Using characteristic signals of the tumor microenvironment, various stimuli-responsive drug delivery systems can be constructed for targeted drug delivery to tumor sites. Among these, the pH is frequently utilized, owing to the pH of the tumor microenvironment being lower than that of blood and healthy tissues. pH-responsive polymer carriers can improve the efficiency of drug delivery in vivo, allow targeted drug delivery, and reduce adverse drug reactions, enabling multifunctional and personalized treatment. pH-responsive polymers have gained increasing interest due to their advantageous properties and potential for applicability in tumor therapy. In this review, recent advances in, and common applications of, pH-responsive polymer nanomaterials for drug delivery in cancer therapy are summarized, with a focus on the different types of pH-responsive polymers. Moreover, the challenges and future applications in this field are prospected.

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Section: Mechanism Of Ph-responsive Polymer Nanomaterials In Tumor Th...mentioning

confidence: 99%

pH-Responsive Polymer Nanomaterials for Tumor Therapy

et al. 2022

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“… 129 Each property has its particular pros and cons for developing a topical nanodrug formulation with improved stability and therapeutic effects. 130 The vitality of drug-loaded polysaccharides and polymers is a consequence of their potential to deliver a desirable amount of drugs to cancer cells without significant effects against normal cells. 130 , 131 For example, curcumin was loaded onto crystalline nanocellulose and caused almost three times higher colorectal cancer cell death than that of curcumin alone.…”

Section: Application Of Polymer In Stabilizing Magnetic Nanocompositesmentioning

confidence: 99%

How Magnetic Composites are Effective Anticancer Therapeutics? A Comprehensive Review of the Literature

Yusefi¹,

Shameli²,

Jahangirian³

et al. 2023

IJN

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Chemotherapy is the most prominent route in cancer therapy for prolonging the lifespan of cancer patients. However, its non-target specificity and the resulting off-target cytotoxicities have been reported. Recent in vitro and in vivo studies using magnetic nanocomposites (MNCs) for magnetothermal chemotherapy may potentially improve the therapeutic outcome by increasing the target selectivity. In this review, magnetic hyperthermia therapy and magnetic targeting using drug-loaded MNCs are revisited, focusing on magnetism, the fabrication and structures of magnetic nanoparticles, surface modifications, biocompatible coating, shape, size, and other important physicochemical properties of MNCs, along with the parameters of the hyperthermia therapy and external magnetic field. Due to the limited drug-loading capacity and low biocompatibility, the use of magnetic nanoparticles (MNPs) as drug delivery system has lost traction. In contrast, MNCs show higher biocompatibility, multifunctional physicochemical properties, high drug encapsulation, and multi-stages of controlled release for localized synergistic chemo-thermotherapy. Further, combining various forms of magnetic cores and pH-sensitive coating agents can generate a more robust pH, magneto, and thermo-responsive drug delivery system. Thus, MNCs are ideal candidate as smart and remotely guided drug delivery system due to a) their magneto effects and guideability by the external magnetic fields, b) on-demand drug release performance, and c) thermo-chemosensitization under an applied alternating magnetic field where the tumor is selectively incinerated without harming surrounding non-tumor tissues. Given the important effects of synthesis methods, surface modifications, and coating of MNCs on their anticancer properties, we reviewed the most recent studies on magnetic hyperthermia, targeted drug delivery systems in cancer therapy, and magnetothermal chemotherapy to provide insights on the current development of MNC-based anticancer nanocarrier.

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“…In addition to esterification, cellulose can react with hydroxyethyl and hydroxypropyl. The former procedure requires substitution of polyethylene glycol to produce polyquaternium derivatives for enhancing drug delivery [54]. Hydroxypropyl cellulose is synthesized by addition of poly (2-dimethylamino ethylmethacrylate) to form a comb-like structure.…”

Section: Cationic Cellulosementioning

confidence: 99%

Layer-by-Layer Cell Encapsulation for Drug Delivery: The History, Technique Basis, and Applications

Lei

Feng

et al. 2022

Pharmaceutics

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The encapsulation of cells with various polyelectrolytes through layer-by-layer (LbL) has become a popular strategy in cellular function engineering. The technique sprang up in 1990s and obtained tremendous advances in multi-functionalized encapsulation of cells in recent years. This review comprehensively summarized the basis and applications in drug delivery by means of LbL cell encapsulation. To begin with, the concept and brief history of LbL and LbL cell encapsulation were introduced. Next, diverse types of materials, including naturally extracted and chemically synthesized, were exhibited, followed by a complicated basis of LbL assembly, such as interactions within multilayers, charge distribution, and films morphology. Furthermore, the review focused on the protective effects against adverse factors, and bioactive payloads incorporation could be realized via LbL cell encapsulation. Additionally, the payload delivery from cell encapsulation system could be adjusted by environment, redox, biological processes, and functional linkers to release payloads in controlled manners. In short, drug delivery via LbL cell encapsulation, which takes advantage of both cell grafts and drug activities, will be of great importance in basic research of cell science and biotherapy for various diseases.

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Simultaneous surface functionalization and drug loading: A novel method for fabrication of cellulose nanocrystals-based pH responsive drug delivery system

Cited by 22 publications

References 48 publications

pH-Responsive Polymer Nanomaterials for Tumor Therapy

pH-Responsive Polymer Nanomaterials for Tumor Therapy

How Magnetic Composites are Effective Anticancer Therapeutics? A Comprehensive Review of the Literature

Layer-by-Layer Cell Encapsulation for Drug Delivery: The History, Technique Basis, and Applications

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