Simultaneous Stability-Indicating Determination of Phenylephrine Hydrochloride, Phenylpropanolamine Hydrochloride, and Guaifenesin in Dosage Forms by Reversed-Phase Paired-Ion High-Performance Liquid Chromatography

Schieffer, Gary W.; Hughes, D. E.

doi:10.1002/jps.2600720113

Cited by 25 publications

(8 citation statements)

References 17 publications

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“…This outcome is in good accordance with the research results of other groups obtained by colour analysis [30], by UV absorbance measurements after cationic exchange resin separation [31], by GC-MS following trimethylsilyl derivatization [29], by HPLC [32] and by LC/MS [33].…”

Section: Phenylephrine Hydrochloridesupporting

confidence: 93%

Investigating the degradation of the sympathomimetic drug phenylephrine by electrospray ionisation-mass spectrometry

Trommer¹,

Raith²,

Neubert³

2010

Journal of Pharmaceutical and Biomedical Analysis

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Section: Phenylephrine Hydrochloridesupporting

confidence: 93%

Investigating the degradation of the sympathomimetic drug phenylephrine by electrospray ionisation-mass spectrometry

Trommer¹,

Raith²,

Neubert³

2010

Journal of Pharmaceutical and Biomedical Analysis

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“…All three drugs are official in Indian pharmacopoeia (IP) [11] and British Pharmacopoeia (BP) [9] . The PCM, CPM and PH alone or in combination with other drugs are reported to be estimated by the spectrophotometric method [12] , [13] , [14] , [15] , derivative spectrophotometric method [16] , chemometric-assisted spectrophotometry [17] , HPLC [18] , [19] , thin layer chromatography (TLC) [20] , liquid chromatography–mass spectrometry (LC–MS) [21] , Fourier transform infrared spectroscopy (FT–IR) [22] , amperometric determination [23] , fluorimetry [24] , micellar electrokinetic chromatographic method [25] , electrophoresis [26] , liquid chromatography with two ultraviolet (UV) absorbance detectors [27] , and chemometric determination [28] .…”

Section: Introductionmentioning

confidence: 99%

Application of RP–HPLC method in dissolution testing and statistical evaluation by NASSAM for simultaneous estimation of tertiary combined dosages forms

Yogesh

Sharma

Sarma

et al. 2015

Journal of Pharmaceutical Analysis

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A dissolution method with robust high performance liquid chromatographic (HPLC) analysis for immediate release tablet formulation was developed and validated to meet the requirement as per International Conference on Harmonization (ICH) and United States Food and Drug Administration (USFDA) guidelines. The method involved the use of Agilent ZORBAX Eclipse XDB C18 column, and temperature was maintained at 30 °C. After optimization, the mobile phase was selected as phosphate buffer (KH2PO4, 30 mM) : ACN (60:40, v/v) with pH 3.0, and retention time Rt was found as 3.24, 4.16, and 2.55 min for paracetamol (PCM), chlorpheniramine maleate (CPM) and phenylephrine hydrochloride (PH) respectively at 265 nm and at a flow rate of 1 mL/min. The relative standard deviation (%RSD) for 6 replicate measurements was found to be less than 2%. Furthermore net analyte signal standard addition method (NASSAM) with spectrophotometer was performed for standard and liquid oral suspension. On the basis of selectivity, sensitivity and accuracy analysis, it was confirmed that this novel method could be useful for simultaneous estimation of the given drug combinations. Two-way analysis of variance (ANOVA) was applied for evaluating the statistical difference between the assay results obtained via both NASSAM and RP–HPLC methods and ultimately no significant difference was found between both the methods. All the methods and results were acceptable and confirmed that the method was suitable for intended use.

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“…Phenylephrine Hydrochloride is [(R)-2-methylamino-1-(3-hydroxyphenyl) ethanol hydrochloride] and used as alpha-adrenergic, sympathomimetic agent as well as vasoconstrictor with little effect on the myocardium or the central nervous system. The literature survey revealed that spectrophotometry [1], RP-HPLC [2], electrophoresis [3], and liquid chromatography [4] methods have been reported for the estimation of phenylephrine hydrochloride in pharmaceutical formulations. The combination of Ibuprofen (IBU) and Phenylephrine HCl (PHE) is available as a tablet formulation in the ratio 200 : 10 mg IBU : PHE.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Estimation of Ibuprofen and Phenylephrine Hydrochloride in Bulk and Combined Dosage Form by First Derivative UV Spectrophotometry Method

Patel

Parmar

2013

Journal of Spectroscopy

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A simple, precise, rapid, and economic method was developed for the simultaneous determination of Ibuprofen and Phenylephrine HCl in bulk and combined dosage form. This method involves first-order derivative spectroscopy using 248 nm and 237 nm as zero crossing points for Ibuprofen and Phenylephrine HCl, respectively. For spectrophotometric method 0.1 N NaOH was used as a solvent. The linearity was established over the concentration range of 12–72 μg/mL and 1.5–22 μg/mL for Ibuprofen and Phenylephrine HCl with correlation coefficient (r2) of 0.9972 and 0.9981, respectively. The mean % recoveries were found to be in the range of 98.88% and 98.54% for Ibuprofen and Phenylephrine HCl, respectively. Interday and intraday studies showed repeatability of the method. The method was found to be specific and robust. The method was successfully applied to pharmaceutical formulation, with no interference from excipients as indicated by the recovery study. Results of analysis were validated statistically and by recovery studies.

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Simultaneous Stability-Indicating Determination of Phenylephrine Hydrochloride, Phenylpropanolamine Hydrochloride, and Guaifenesin in Dosage Forms by Reversed-Phase Paired-Ion High-Performance Liquid Chromatography

Cited by 25 publications

References 17 publications

Investigating the degradation of the sympathomimetic drug phenylephrine by electrospray ionisation-mass spectrometry

Investigating the degradation of the sympathomimetic drug phenylephrine by electrospray ionisation-mass spectrometry

Application of RP–HPLC method in dissolution testing and statistical evaluation by NASSAM for simultaneous estimation of tertiary combined dosages forms

Simultaneous Estimation of Ibuprofen and Phenylephrine Hydrochloride in Bulk and Combined Dosage Form by First Derivative UV Spectrophotometry Method

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