Simultaneous spectrophotometric estimation of Salbutamol, Theophylline and Ambroxol three component tablet formulation using simultaneous equation methods

Kalyani, L.; Rao, Chava V N

doi:10.1016/j.kijoms.2018.01.004

Cited by 16 publications

(12 citation statements)

References 21 publications

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“…In this study working standard solutions were prepared over the concentration range 10-50 mg/L and 10-55 mg/L for Ampyrone and its acidic product, respectively. And the absorbance at 243 nm (λ max of Ampyrone) and 257 nm (λ max of acidic product) were selected and measured for the formation of simultaneous equations [20,21].…”

Section: Simultaneous Equation Methodsmentioning

confidence: 99%

Different Mathematical Spectrophotometric Methods for Determination of Ampyrone in Presence of Its Acid Degradation Product

Abbas

2020

MJS

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Three simple spectrophotometric methods namely; area under the curve, simultaneous equation method, and modified simultaneous equation method was developed and validated for the determination of Ampyrone with the presence of its acidic product using zero-order spectra without prior separation techniques. The linearity was found in the range of (10-50 mg/L) and (10-55 mg/L) for Ampyrone and its acidic product, respectively. The recovery percentage was found to be in the range from 99.6 to 100.65 for the area under curve method and 96.64 to 104.8 for the simultaneous equation method and its modified version which showed good accuracy and precision for three proposed methods.

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Section: Simultaneous Equation Methodsmentioning

confidence: 99%

Different Mathematical Spectrophotometric Methods for Determination of Ampyrone in Presence of Its Acid Degradation Product

Abbas

2020

MJS

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“…Further, the developed methods were evaluated for their greenness profile using greenness tools such as analytical eco scale and agree metrics. The principle of the simultaneous equation technique [8] is that when a sample solution includes three drugs (X, Y, and Z) with dissimilar λmax, the concentration of all the three analytes (Cx, Cy, and Cz) is calculated using a simple simultaneous equation [9] using absorptivity of X at λ1, λ2, and λ3 (ax1, ax2, ax3); the absorptivity of Y at λ1, λ2, and λ3 (ay1, ay2, ay3); and absorptivity of Z at λ1, λ2, and λ3 (az1, az2, az3) and absorbance of the sample at λ1, λ2, and λ3 (A1, A2, and A3)…”

Section: Introductionmentioning

confidence: 99%

“…The estimation of drugs in mixtures and multi-component pharmaceutical formulation with overlapping spectra can be estimated more accurately and free from interferences by chemometric calibration techniques. The PCR and PLS used in the present study The principle of the simultaneous equation technique [8] is that when a sample solution includes three drugs (X, Y, and Z) with dissimilar λ max , the concentration of all the three analytes (C x , C y , and C z ) is calculated using a simple simultaneous equation [9] using absorptivity of X at λ 1 , λ 2 , and λ 3 (ax 1 , ax 2 , ax 3 ); the absorptivity of Y at λ 1 , λ 2 , and λ 3 (ay 1 , ay 2 , ay 3 ); and absorptivity of Z at λ 1 , λ 2 , and λ 3 (az 1 , az 2 , az 3 ) and absorbance of the sample at λ 1 , λ 2 , and λ 3 (A 1 , A 2 , and A 3 )…”

Section: Introductionmentioning

confidence: 99%

Ecofriendly Simple UV Spectrophotometric and Chemometric Methods for Simultaneous Estimation of Paracetamol Aceclofenac and Eperisone Hydrochloride in Pharmaceutical Formulation: Assessment of Greenness Profile

Rathinam

Santhana

2021

Processes

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This work introduces three eco-friendly UV spectrophotometric methods for the simultaneous estimation of Paracetamol, Aceclofenac and Eperisone Hydrochloride in pharmaceutical tablet formulation. The procedures employed were simultaneous equation method and multivariate chemometric methods with phosphate buffer pH 7.80 as diluent. The simultaneous equation method encompasses absorbance measurement at three different wavelengths (λmax of the drugs). It exhibits linearity between 12–18 µg mL−1 for paracetamol, 3.69–5.53 µg mL−1 for Aceclofenac, and 2.76–4.15 µg mL−1 Eperisone hydrochloride. The results obtained for accuracy and precision by the simultaneous equation method were within the permissible limits. Principal component regression and partial least squares were the tools used for chemometric methods. The calibration set and prediction set were constructed, and the UV spectra were recorded in zero order mode, further subjected to chemometric analysis. The % recoveries obtained for Paracetamol, Aceclofenac, and Eperisone Hydrochloride by chemometric techniques showed good accuracy, and the results obtained for analytical figures of merit were acceptable. Statistical comparison of the assay results obtained for the proposed methods showed no significant difference found among the methods using one way analysis of variance. Greenness evaluation tools revealed the greenness profile of the proposed methods and found them to be ecofriendly. The described methods were appropriate for routine quality control laboratories, facilitating eco-friendly, fast, and cost effective determination of Paracetamol, Aceclofenac, and Eperisone Hydrochloride in Acemyoset P tablets.

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“…For these potential side effects, detection of the SBS in body fluids and urine is very important. Spectrophotometric techniques [4][5][6][7][8], gas chromatography-mass spectrometry [9,10], high performance liquid chromatography [11,12], liquid chromatography-mass spectrometry [13][14][15], capillary electrophoresis [16][17][18][19][20] and chemiluminescence [21,22] are used for the determination of salbutamol in different samples. These techniques need costly equipment, competent personnel and require complex sample pretreatment procedure.…”

Section: Introductionmentioning

confidence: 99%

Determination of Salbutamol Sulfate in pharmaceutical formulation with differential pulse voltammetry using poly(Benzofuran-2-Boronic acid) modified platinum electrode

Güngör

2021

Cumhuriyet Science Journal

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In this study, determination of salbutamol sulfate (SBS) was carried out using poly(benzofuran-2-boronic acid)/platinum electrode (BF2BA/PtE). Polymerization of BF2BA was conducted in acetonitrile (AcN) containing 0.1 M sodium perchlorate (NaClO4) on bare PtE by cyclic voltammetry (CV) method. The electrochemical properties of the prepared polymer electrode were investigated by CV and electrochemical impedance spectroscopy (EIS) techniques in ferricyanide/KNO3 solution. Then, prepared poly(BF2BA/PtE) was used for detection of the SBS. Monomer type, concentration, the number of cycles and scan rate were worked using differential pulse voltammetry (DPV) in citrate-phosphate buffer containing 1.15 mM SBS. The effects of parameters such as electrolyte type, pH effect on SBS DPV responses were studied. The SBS responses of the modified electrodes were also investigated by square wave voltammetry (SWV). The oxidative current peak stem from SBS concentration showed at 0.65V potential and a linear calibration curve was obtained in the range from 50 to 2000 μM SBS concentration. Limit of dedection (LOD), and limit of quantitation (LOQ), was calculated as 49.14 µM and 163.80 µM, respectively. The recovery efficiency for synthetic urine samples was obtained from 91.47 to 110.43% by using BF2BA/PtE.

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Simultaneous spectrophotometric estimation of Salbutamol, Theophylline and Ambroxol three component tablet formulation using simultaneous equation methods

Cited by 16 publications

References 21 publications

Different Mathematical Spectrophotometric Methods for Determination of Ampyrone in Presence of Its Acid Degradation Product

Different Mathematical Spectrophotometric Methods for Determination of Ampyrone in Presence of Its Acid Degradation Product

Ecofriendly Simple UV Spectrophotometric and Chemometric Methods for Simultaneous Estimation of Paracetamol Aceclofenac and Eperisone Hydrochloride in Pharmaceutical Formulation: Assessment of Greenness Profile

Determination of Salbutamol Sulfate in pharmaceutical formulation with differential pulse voltammetry using poly(Benzofuran-2-Boronic acid) modified platinum electrode

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