Simultaneous sinus lift and implantation using platelet-rich fibrin as sole grafting material

Jeong, Seung Mi; Lee, Chun Ui; Son, Jeong Seog; Oh, Jung Hyub; Fang, Yiqin; Choi, Byung Ho

doi:10.1016/j.jcms.2014.01.021

Cited by 41 publications

(39 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Importantly, the maturation of this type of material may take up to 8 months before implants can be safely placed in maxillary sinus, which might be considered a disadvantage of this material. To mitigate this shortcoming, the addition of growth factors, particularly L‐PRF, to the graft material has been suggested as an alternative approach to increase bone formation, enhance implant stability, favor osseointegration, and accelerate tissue maturation and healing …”

Section: Discussionmentioning

confidence: 99%

Evaluation of L‐PRF combined with deproteinized bovine bone mineral for early implant placement after maxillary sinus augmentation: A randomized clinical trial

Pichotano

Molon

Souza

et al. 2019

Clin Implant Dent Rel Res

104

View full text Add to dashboard Cite

Purpose To investigate the effectiveness of adding leukocyte and platelet‐rich fibrin (L‐PRF) to deproteinized bovine bone mineral (DBBM) for early implant placement after maxillary sinus augmentation. Materials and Methods Twelve patients requiring two‐stage bilateral maxillary sinus augmentation were enrolled to the study. The elevated sinus cavities were randomly grafted with DBBM + L‐PRF (test) or DBBM alone (control) in a split‐mouth design. Implants were placed in the augmented sites after 4 months in the test group and 8 months in the control group. Bone biopsies were collected during implant placement for histomorphometric evaluation. Resonance frequency analysis was performed immediately after implant placement and at implant loading in both groups. Cone‐beam computed tomography was obtained preoperatively and postoperatively for evaluation of graft volume changes. Results Both procedures were effective for maxillary sinus augmentation. Cone‐beam computed tomography analysis did not reveal differences in graft volume between test and control group at any of the evaluated time points (P > .05). Histological evaluation demonstrated increased percentage of newly formed bone for the test group (44.58% ± 13.9%) compared to the control group (30.02% ± 8.42%; P = .0087). The amount of residual graft in the control group was significantly higher (13.75% ± 9.99%) than in the test group (3.59 ± 4.22; P = .0111). Implant stability quotient (ISQ) immediately after implant placement was significantly higher in the control group (75.13 ± 5.69) compared to the test group (60.9 ± 9.35; P = .0003). The ISQ values at loading did not differ between the groups (P = .8587). Implant survival rate was 100% for both groups. Conclusion The addition of L‐PRF to the DBBM into the maxillary sinus allowed early implant placement (4 months) with increased new bone formation than DBBM alone after 8 months of healing.

show abstract

Section: Discussionmentioning

confidence: 99%

Evaluation of L‐PRF combined with deproteinized bovine bone mineral for early implant placement after maxillary sinus augmentation: A randomized clinical trial

Pichotano

Molon

Souza

et al. 2019

Clin Implant Dent Rel Res

104

View full text Add to dashboard Cite

show abstract

“…There exist numerous new developments and techniques in dental implantology, which continuously improve the outcomes, such as nano-crystalline diamond-coated titanium implants, fluoridated implants and platelet-rich fibrin (PRF) as sole grafting material (Metzler et al, 2013;Dasmah et al, 2014;Jeong et al, 2014). Nevertheless, the implant-supported masticatory restoration of the posterior maxilla represents a specific challenge, due to specific anatomical and biological conditions.…”

Section: Introductionmentioning

confidence: 99%

Analysis of implant-failure predictors in the posterior maxilla: A retrospective study of 1395 implants

Pabst

Ehbauer

Zwiener³

et al. 2015

Journal of Cranio-Maxillofacial Surgery

View full text Add to dashboard Cite

“…Heterogeneous results were found in dog models of sinus lift concomitant to implant placement. While adding PRF to autogenous bone (Lee, Choi, Jung, Zhu & Lee, ) or DBBM (Xuan, Lee, Son, Jeong & Choi, ) led to significantly greater BIC and bone formation, in another study, simultaneous sinus lift and implantation using PRF as sole grafting material did not result in predictable and reproducible results (Jeong, Lee, Son, Oh & Fang, ).…”

Section: Resultsmentioning

confidence: 99%

The use of bioactive factors to enhance bone regeneration: A narrative review

Donos

Dereka

Calciolari

2019

J Clinic Periodontology

View full text Add to dashboard Cite

Aim This review critically appraises the available knowledge on the pre‐clinical and clinical use of bioactive factors for bone regeneration in the cranial and maxillofacial area. Materials and Methods The use of growth factors, amelogenins and autologous platelet concentrates (APCs) for bone regeneration was reviewed in a systematic manner. More specifically, pre‐clinical and clinical studies on ridge preservation, alveolar ridge augmentation, regeneration of peri‐implant defects and sinus augmentation models were considered. Results Amongst different bioactive factors, the highest pre‐clinical and clinical evidence of a positive effect on bone formation is associated with rhBMP‐2 and the lowest with amelogenins. While APCs seem to accelerate clinical healing and reduce postoperative discomfort, there is insufficient and contrasting evidence of a significant effect on hard tissue regeneration for the different clinical applications. Conclusions Although there is increasing evidence that bioactive factors might enhance the bone regeneration process, the great heterogeneity of the available studies and the limited number of RCTs do not allow to draw robust conclusions. Issues that still need to be investigated include the optimal carriers for bioactive agents (direct vs. indirect), the dosage, the timing of administration, as well as the possibility of combining different agents to promote synergistic effects.

show abstract

Simultaneous sinus lift and implantation using platelet-rich fibrin as sole grafting material

Cited by 41 publications

References 13 publications

Evaluation of L‐PRF combined with deproteinized bovine bone mineral for early implant placement after maxillary sinus augmentation: A randomized clinical trial

Evaluation of L‐PRF combined with deproteinized bovine bone mineral for early implant placement after maxillary sinus augmentation: A randomized clinical trial

Analysis of implant-failure predictors in the posterior maxilla: A retrospective study of 1395 implants

The use of bioactive factors to enhance bone regeneration: A narrative review

Contact Info

Product

Resources

About