Simultaneous Seroprevalence to Toxoplasma gondii, Cytomegalovirus and Rubella Virus in Childbearing Women from Western Romania

Mocanu, Adelina Geanina; Gorun, Florin; Ciohat, Ioana; Navolan, Dan; Malița, Daniel; Vilibić-Čavlek, Tatjana; Dahma, George; Neamtu, Radu; Popescu, Daniela-Eugenia; Cioca, Andreea; Craina, Marius

doi:10.3390/medicina57090927

Cited by 12 publications

(34 citation statements)

References 24 publications

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“…In our study, there was a marked increase in the number of tests carried out between 2013-2016 and 2019-2022, as reported by other researchers from Romania who studied various agents in the TORCH complex [18][19][20]. Most pregnant women were from rural In regard to HSV-2 exposure, the highest prevalence percentages were recorded in the localities of Bucovat and Calafat, with values of approximately 30%.…”

Section: Discussionsupporting

confidence: 77%

Seroprevalence of Herpes Simplex Virus Types 1 and 2 among Pregnant Women in South-Western Romania

Radoi,

Cristea,

Vulcanescu

et al. 2024

Life

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Background: Pregnancy-related infections with the human herpes simplex virus (HSV) strains HSV-1 and HSV-2 are particularly noteworthy. There are numerous reported examples of intrapartum transmission of herpes infection, notwithstanding the extreme rarity of intrauterine transfer from mother to fetus. The purpose of this study was to evaluate the seroprevalence of HSV-1 and HSV-2 antibodies in pregnant women in the western region of Romania. Methods: Pregnant women who presented for routine pregnancy monitoring at Romania’s County Clinical Emergency Hospital in Craiova between 2013 and 2016 and 2019 and 2022 were included in the study. In order to find anti-HSV-1/2 IgG antibodies, we conducted serological testing on the patients and gathered demographic information from them. Results: HSV-1 seroprevalence was shown to have declined in rural areas and increased in urban areas, with values between 2013 and 2016 being 89.30% and those between 2019 and 2022 being 84.96%, respectively. Women over 35 who were pregnant had the highest seroprevalence. The seroprevalence of HSV-2 decreased from 16.16% in 2013–2016 to 12.43% in 2019–2022, and both rural and urban areas continued to experience this declining trend. Similarly, pregnant women over 35 years old had the highest frequency of HSV-1 infections. Conclusions: Establishing educational programs and other actions to reduce the transmission rate and ultimately the prevalence of the disease can be made easier with knowledge about the seroprevalence of HSV-1 and HSV-2 infections.

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Section: Discussionsupporting

confidence: 77%

Seroprevalence of Herpes Simplex Virus Types 1 and 2 among Pregnant Women in South-Western Romania

Radoi,

Cristea,

Vulcanescu

et al. 2024

Life

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“…The main pathogens that could cross the placenta following the infection of a pregnant woman and cause severe damage to the offspring belong to the TORCH group, which represents an acronym formed by the initial letters of the names of the following pathogens ( Toxoplasma gondii , other pathogens, Rubella virus, Cytomegalovirus, Herpes simplex virus) [ 11 ]. Toxoplasma gondii (TG) is an obligate intracellular zoonotic parasite which can cause several congenital malformations if an acute primary infection occurs during pregnancy [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

The Impact of Latent Toxoplasma gondii Infection on Spontaneous Abortion History and Pregnancy Outcomes: A Large-Scale Study

et al. 2022

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Background: Toxoplasma gondii (TG), a zoonotic protozoan parasite, belongs to a group of TORCH infectious agents, which can cause severe damage to the fetus if a primary infection occurs during pregnancy. After primary infection, TG rests lifelong in human organisms causing a latent infection. Most studies have analyzed the consequences of acute, but not latent, TG infection. This study analyzed the impact of latent toxoplasmosis on spontaneous abortion history, pregnancy complication rate and neonatal outcome. Methods: IgG and IgM anti-TG antibodies were tested in 806 pregnant women who were consulted at the Timisoara Clinical Emergency Hospital between 2008 and 2010. Demographic data, obstetrical history, and data about the pregnancy complications, birth and neonate were collected for each woman and comparisons between the groups, with and without latent TG infection, were made. Results: This study did not show differences between groups regarding the history of spontaneous abortion (OR = 1.288, p = 0.333), cesarean section (OR = 1.021, p = 0.884), placental abruption (OR 0.995, p = 0.266), pregnancy-induced hypertension rate (OR 1.083, p = 0.846), secondary sex ratio (1.043, p = 0.776), 1′ APGAR score at birth (p = 0.544), gestational age at birth (p = 0.491) or birth weight (p = 0.257). Conclusions: The observed differences between the rate of pregnancy complications in the two groups of pregnant women with and without latent infection with TG, did not reach a statistical significance.

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“…Of 341 (88.11%) reactive samples 31 . A similar study conducted by Mocanu et al, in 2021, reported that 38 % of patients were positive for TORCH although the same diagnostic techniques for example ICT and CMIA were applied for the detection of Toxoplasma, CMV, and RV 32 . A study documented from the western area of Romania showed a very high prevalence of CMV 91.8 % among women in the reproductive period 33 .…”

Section: Discussionmentioning

confidence: 88%

“…The maximum number of pregnant women was positive 77.2 % in the age group of 26-35 years 46 . The rate of simultaneous seropositivity to, CMV, Toxoplasma gondii, and Rubella virus among Romanian pregnant women reduced significantly between 2008---2010, and 2015-2018 while the susceptibility to these infections increased 32 .…”

Section: Discussionmentioning

confidence: 91%

Evaluation of Herpes, Cytomegalovirus, Rubella, and Toxoplasma Gondii Infections in Swabi, KPK, Pakistan

Mahmood¹,

Zafar²,

Noreen³

et al. 2022

PJMHS

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Introduction: Toxoplasma gondii (TG), Rubella virus (RV), Cytomegalovirus (CMV), and Herpes simplex virus (HSV) 1 and 2, globally most neonatal and infant deaths are reported due to this group of infections. Purpose: The objective of this research study is to estimate the Prevalence of TORCH infections. Methods: This research study was carried out at the Hi-Tech clinical laboratory Shewa Adda Swabi KPK Pakistan for a duration of 4 months from April 2022 to July 2022. Data statistics looking at the clinical characteristics of Toxoplasma gondii, CMV, RV, and HSV were filled from n=371. All samples were qualitative and quantitative tested by using Immune chromatographic (ICT) and Chemiluminescence Microparticle Immunoassay (CMIA) techniques. Results: Out of n=317 pregnant women, n=131 (35 %) women were found positive while n=240 (65 %) women were found negative. Prevalence of Toxoplasma gondi 32 %, RV 28 %, CMV 27 %, and HSV 13 % in Swabi, KPK, and Pakistan. Among them, a high-frequency fraction of co-infection was detected for CMV and Rubella 17 (58 %), followed by CMV, Herpes, Rubella virus, and Toxoplasma gondii combined 7(25 %). The highest number of infected individuals 37 % we found in the age-group 21-25 years, followed by the 15-20 years age group 23 %, 26-30 years age group 17 %, 31-35 years age group 23 % while the lowest number of positive individuals found in >36 age group. Conclusion: In brief context, TORCH pathogens have potentially shocking clinical manifestations. Hence, screening before pregnancy, and timely diagnosis of TORCH can reduce disease and death in both kid, and the mother. Moreover, knowing the epidemiology survey is a significant aspect to develop strategies and implementation for the prevention of disease. Keywords: Pregnancy, Prevalence, TORCH, Swabi, Infections.

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Simultaneous Seroprevalence to Toxoplasma gondii, Cytomegalovirus and Rubella Virus in Childbearing Women from Western Romania

Cited by 12 publications

References 24 publications

Seroprevalence of Herpes Simplex Virus Types 1 and 2 among Pregnant Women in South-Western Romania

Seroprevalence of Herpes Simplex Virus Types 1 and 2 among Pregnant Women in South-Western Romania

The Impact of Latent Toxoplasma gondii Infection on Spontaneous Abortion History and Pregnancy Outcomes: A Large-Scale Study

Evaluation of Herpes, Cytomegalovirus, Rubella, and Toxoplasma Gondii Infections in Swabi, KPK, Pakistan

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