Simultaneous separation and determination of 15 organic <scp>UV</scp> filters in sunscreen cosmetics by <scp>HPLC</scp>–<scp>ESI</scp>‐<scp>MS</scp>/<scp>MS</scp>

Meng, Xianshuang; Ma, Qiang; Bai, Hua; Wang, Ziming; Han, Chao; Wang, Chuanxian

doi:10.1111/ics.12387

Cited by 17 publications

(7 citation statements)

References 31 publications

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“…The step of dissolving the cosmetic sample may be preceded by homogenisation. Depending on the cosmetic product’s type (i.e., consistency), the next steps in the procedure may include sonicating the sample for a few minutes (5–30 min, 40 °C) [ 10 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ], magnetic mixing [ 34 , 35 ], mechanical shaking [ 20 , 36 ], vortexing (3–4 min), [ 25 , 29 , 32 , 37 ], or centrifuging (1–20 min, 3500–14,800 rpm) [ 14 , 19 , 20 , 25 , 27 , 29 , 32 , 33 ], which can help accelerate the solubilisation. The obtained supernatant is often filtered as well (e.g., 0.45 µm nylon membrane filter) [ 10 , 13 , 14 , 15 , 16 , 17 , 18 , 21 , 22 , 23 ...…”

Section: Analytical Methods For Uv Filter Determination In Cosmetic Samplesmentioning

confidence: 99%

An Overview of the Analytical Methods for the Determination of Organic Ultraviolet Filters in Cosmetic Products and Human Samples

Narloch

Wejnerowska

2021

Molecules

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UV filters are a group of compounds commonly used in different cosmetic products to absorb UV radiation. They are classified into a variety of chemical groups, such as benzophenones, salicylates, benzotriazoles, cinnamates, p-aminobenzoates, triazines, camphor derivatives, etc. Different tests have shown that some of these chemicals are absorbed through the skin and metabolised or bioaccumulated. These processes can cause negative health effects, including mutagenic and cancerogenic ones. Due to the absence of official monitoring protocols, there is an increased number of analytical methods that enable the determination of those compounds in cosmetic samples to ensure user safety, as well as in biological fluids and tissues samples, to obtain more information regarding their behaviour in the human body. This review aimed to show and discuss the published studies concerning analytical methods for the determination of organic UV filters in cosmetic and biological samples. It focused on sample preparation, analytical techniques, and analytical performance (limit of detection, accuracy, and repeatability).

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Section: Analytical Methods For Uv Filter Determination In Cosmetic Samplesmentioning

confidence: 99%

An Overview of the Analytical Methods for the Determination of Organic Ultraviolet Filters in Cosmetic Products and Human Samples

Narloch

Wejnerowska

2021

Molecules

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“…Over‐exposure to ultraviolet (UV) light is the major cause of skin cancers, including cutaneous melanoma, basal‐cell carcinoma, and squamous‐cell carcinoma . One way to protect the skin from harmful UV rays is by applying sunscreen . Sunscreens are a heterogeneous group of organic or inorganic compounds .…”

Section: Introductionmentioning

confidence: 99%

“…1,2 One way to protect the skin from harmful UV rays is by applying sunscreen. 3 Sunscreens are a heterogeneous group of organic or inorganic compounds. 4 The active ingredients in organic sunscreens that absorb UV radiation include, among others, oxybenzone, avobenzone, homosalate, octisalate, octocrylene, and octinoxate.…”

Section: Introductionmentioning

confidence: 99%

In vitro metabolism of sunscreen compounds by liquid chromatography/high‐resolution tandem mass spectrometry

Guesmi

Ohlund

Sleno

2020

Rapid Comm Mass Spectrometry

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Rationale Exposure to UV light can induce adverse effects on human health, such as photo‐aging, immunosuppression, and cancer. Sunscreens are used to prevent the absorption of UV rays, but certain UV‐filtering compounds have been shown to disrupt endocrine systems or act as carcinogens. To assess the effects of the exposure to such compounds, it is important to study the pathways by which they are biotransformed in the body. Methods Liquid chromatography coupled to high‐resolution tandem mass spectrometry (LC/HRMS/MS) was employed to evaluate the oxidative metabolism and, specifically, the formation of reactive metabolites of six active ingredients commonly used in sunscreen formulations: oxybenzone, avobenzone, homosalate, octisalate, octocrylene, and octinoxate. In vitro incubations were performed with human and rat liver microsomes in the presence of β‐nicotinamide adenine dinucleotide phosphate and glutathione. An LC/HRMS/MS method was developed to identify metabolites employing a biphenyl reversed‐phase column for separating parent molecules, metabolites, and glutathione (GSH) adducts. Results Each tested compound resulted in the formation of several metabolites, including at least one GSH adduct. Compounds containing ester groups were hydrolyzed, and some metabolites of the free acid forms were also detected. High‐resolution MS/MS data was crucial for the structural elucidation of metabolites and GSH adducts. Fragmentation pathways were proposed for all parent compounds, as well as each described metabolite and adduct. Conclusions The results of this study will help better understand the metabolism and detoxification pathways of these xenobiotics.

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“…Organic sunscreen agents in various cosmetic products were estimated using GC-MS [7] [8] . Simultaneous determination of organic UV filters was successively achieved by using HPLC-UV/DAD [9][10][11][12][13][14][15][16][17][18][19][20][21][22] . Sunscreens are regulated by The Saudi Standards, Metrology and Quality Organization (SASO) [23] .…”

Section: Introductionmentioning

confidence: 99%

تقدير اربعة مرشحات للأشعة الفوق بنفسجية في منتجات الوقاية من اشعة الشمس باستخدام جهاز الكروماتوجرام السائل عالي الأداء – كاشف الصمام الثنائي

و¹

2018

JKAU Sci

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لتقييم اثني عشر منتج من منتجات الحماية من الشمس المتواجدة في السوق السعودي باستخدام طريقة HPLC-DAD، تم تقدير أربعة مرشحات للأشعة فوق البنفسجية (,Benzophenone-3 ,Homosalate Octisalate and (Octinoxateوتم وزن العينة ثم تخفيفها وتشتيتها بالميثانول وأجهزة الطرد المركزي ثم تحليلها. تظهر منحنيات المعايرة للمعايير خطية جيدة، حيث R2 تراوحت (0.9998 إلى 0.9999).وجد ان تركيز المرشحات الاشعة الفوق بنفسجية قد تراوحت من (1.32-7.88?) وكانت ضمن الحدود المسموح بها في هيئة المواصفات والمقاييس السعودية ، والذي يؤكد على سلامة الكريمات، وتحتوي كل عينة على عوامل واقية من الشمس من (1 إلى 3) ، في حين أن 4 كريمات لم يكشف بها أيًا من هذه العوامل، وتراوحت تركيزات مرشحات الأشعة فوق البنفسجية الإجمالية على نفس العينة (2.4-16.88?). طريقة HPLC-DAD كانت فعالة لمراقبة جودة مستحضرات التجميل التجارية.

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Simultaneous separation and determination of 15 organic UV filters in sunscreen cosmetics by HPLC–ESI‐MS/MS

Abstract: The experimental results demonstrated that the developed method was accurate, rapid and sensitive and can be used for the analytical control of sunscreen cosmetics.

Cited by 17 publications

References 31 publications

An Overview of the Analytical Methods for the Determination of Organic Ultraviolet Filters in Cosmetic Products and Human Samples

An Overview of the Analytical Methods for the Determination of Organic Ultraviolet Filters in Cosmetic Products and Human Samples

In vitro metabolism of sunscreen compounds by liquid chromatography/high‐resolution tandem mass spectrometry

تقدير اربعة مرشحات للأشعة الفوق بنفسجية في منتجات الوقاية من اشعة الشمس باستخدام جهاز الكروماتوجرام السائل عالي الأداء – كاشف الصمام الثنائي

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