Simultaneous screening and quantitation of alpidem, zolpidem, buspirone and benzodiazepines by dual-channel gas chromatography using electron-capture and nitrogen—phosphorus detection after solid-phase extraction

Screening for Drugs of Abuse (II): Cannabinoids, Lysergic Acid Diethylamide, Buprenorphine, Methadone, Barbiturates, Benzodiazepines and other Drugs

“…Selective elution with water: methanol: acetonitrile (2: 3: 3) allowed differentiation from tricyclic antidepressants, which could be later eluted with 0·6% diethylamine in rnethanol.l" Casas et al 219 extracted seven benzodiazepines from urine and plasma using a variety of solid phase materials. They found C2 columns to be superior to C 18, C 12 and C8 columns with 90'Yo extraction and little endogenous interference, although Gaillard et al 220 obtained similar results using C8 columns eluting with 0·5% acetic acid in methanol. Where other drugs are also present, a mixed bed column may be preferable.P' Extraction using Sep-pak C-18 cartridges (Waters Corporation, Milford, MA, USA) as a preliminary to capillary GC is less effective for plasma than for urine."!"…”

Analytical Determination of Buspirone Hydrochloride in Pure Solutions, Pharmaceutical Preparation and Urine Samples

“…Several analytical methods have been applied to determine Buspirone hydrochloride (Bu-HCl) quantitatively in their dosage forms including spectrophotometric method [2][3][4][5], liquid chromatography mass spectrometry LC/MS [6][7][8][9], High Performance Liquid Chromatogrphy HPLC [10][11][12][13][14][15][16][17][18], gas chromatography [19] gas chromatography mass spectrometry GCMS [20][21][22], ion selective electrode [20][21][22][23] and potentiometry [24][25][26].…”

Modern Methods for Analysis of Antiepileptic Drugs in the Biological Fluids for Pharmacokinetics, Bioequivalence and Therapeutic Drug Monitoring

“…For analytical methods for CBM in biological fluids, GC and HPLC are the methodology currently used [35]. Most of GC methods using electron capture (EC), nitrogen-phosphorus (NP) to achieve limits of detection of 3∼5 ng/ml [36,37] and MS detection [34,38] have been described for the quantitation of CBM and N-desmethyl-CBM in serum. HPLC method with UV [29,[39][40][41] and MS [4,42] detection are also available.…”