Simultaneous screening and confirmation of multiple classes of drug residues in fish by liquid chromatography-ion trap mass spectrometry

Determination of Dimetridazole, Metronidazole and Ronidazole in Salmon and Honey by Liquid Chromatography Coupled with Tandem Mass Spectrometry

“…Analytical methods for detecting DMZ, MNZ and RNZ residues in trout and tilapia have been proposed using UV detection 6), 7) . Smith et al 9) have reported success using LC-ion trap MS strategies for detecting MNZ in salmon, trout, catfish and tilapia; however, no other methods have been found for the simultaneous determination of DMZ, MNZ and RNZ in salmon by LC-MS/MS. The o$cial Japanese method does not employ a solid-phase extraction step.…”

“…Various techniques have been used for the determination of DMZ, MNZ and RNZ, such as gas chromatography (GC) 4) , gas chromatography-mass spectrometry (GC-MS) 5) , liquid chromatography (LC) 6)ῌ8) , liquid chromatography-mass spectrometry (LC-MS) 9)ῌ11) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) 12)ῌ19) . Analytical methods for detecting DMZ, MNZ and RNZ residues in trout and tilapia have been proposed using UV detection 6), 7) .…”

Assessment of the Occurrence and Potential Risks of Pharmaceuticals and their Metabolites in Fish and Water Using Liquid Chromatography Mass Spectrometry

“…Fish are sensitive indicators for substances that enter aquatic ecosystems (EPA 2009). Numerous studies have shown that long-term exposure to pharmaceuticals and personal care products (PPCPs) may result in accumulation of parent compounds, their metabolites, or both in tissues of aquatic organisms, suggesting that further studies on secondary effects of PPCPs on aquatic organisms are necessary (Brooks et al 2005;Tang et al 2006;Chu and Metcalfe 2007;Ramirez et al 2007;Berrada et al 2008;Nakamura et al 2008;Zhou et al 2008;Ramirez et al 2009;Smith et al 2009). …”

“…As the list of compounds found in field collected fish samples expands, the need to develop simultaneous screening methods for multiple classes of drug residues increases as well (Balmer et al 2004;Duedahl-Olesen et al 2005;Buser et al 2006;Rudel et al 2006;Mottaleb et al 2009). At present, the general approach employed for the analysis of multi-class pharmaceuticals in fish involves extraction of homogenized tissue with 1:1 mixture of 0.1 M acetic acid and methanol (Ramirez et al 2007), or acetonitrile combined with limited cleanup to back-extract lipid material followed by liquid chromatography-mass spectrometry (LC-MS) analysis (Smith et al 2009). Additionally, the use of solid-phase microextraction (SPME) techniques has also been explored as surrogates to estimate the potential occurrence and uptake of pharmaceuticals in living fish by assuming similar partition behavior between the SPME devices and the fish tissues placed in contaminated environments (Zhou et al 2008).…”

Development and validation of analytical method for sulfonamide residues in eggs by liquid chromatography Tandem Mass Spectrometry based on the Comission Decision 2002/657/EC

“…Some methods using LC-MS/MS are available in the literature. [40][41][42][43][44][45][46][47][48][49][50][51][52] Additionally, there are studies that use MS to analyze eggs, which are a very popular protein source. 38,39,53,54 These studies used electrospray ion source (ESI), that is a good interface for sulfonamides, but two of them used a single quadrupole as analyzer.…”