Simultaneous resection of pancreas and liver metastases from different metachronous primary cancers

Abstract

Resection of a pancreatic head tumor and partial resection of the liver for metastatic lesions were carried out simultaneously in a 72-year-old woman. The patient had a history of two previous operations, right nephrectomy for renal cell carcinoma (clear cell type), done 14 years previously, and an Autincloss procedure for cancer of the left breast (solid tubular carcinoma); (T1N0M0; stage I) done 7 years previously. At the current presentation, preoperative radiographic examination showed a hypervascular tumor in each of the pancreatic and hepatic lesions, but with different patterns. On the basis of histological findings in the two resected specimens, it was difficult to establish whether the hepatic tumor originated from the renal cell carcinoma or the breast cancer, but postoperative immunohistochemical studies for carcinoembryonic antigen (CEA), estrogen receptors, and gross cystic disease fluid protein (GCDFP)-15 showed that the pancreatic tumor had metastasized from the renal cell carcinoma, and the liver tumor from the breast cancer. The immunohistochemical investigation of different markers thus proved to be useful in making the final diagnosis of metastatic lesions from different and metachronous cancers.

Enabling Bifunctionality and Hemilability of N‐Heteroaryl NHC Complexes

“…A total of 411 patients who underwent resection of pancreatic RCC metastases were described in 170 articles1, 2, 5–7, 14–178. Data for individual patients were not provided in ten reports containing a total of 100 patients27, 29, 63, 68, 75, 113, 119, 122, 159, 176.…”

Prolactin inducible protein in cancer, fertility and immunoregulation: structure, function and its clinical implications

“…PIP has also been used to discriminate between primary tumors of ovary, breast, and colon [107]. In another study, [108] PIP showed metastasis in renal cell carcinoma, pancreatic carcinoma and the liver tumor along with breast cancer. Immunohistochemical analysis showed the over-expression of PIP in adenocarcinoma of the brain [109] and lung adenocarcinoma [92, 94, 110 -112].…”