Simultaneous red and infrared light-emitting diodes reduced pain in individuals with temporomandibular disorder: a randomized, controlled, double-blind, clinical trial

Sousa, Dowglas Fernando Magalhães de; Deana, Alessandro Melo; Horliana, Anna Carolina Ratto Tempestini; Fernandes, Kristianne Porta Santos; Bussadori, Sandra Kalil; Mesquita‐Ferrari, Raquel Agnelli

doi:10.1007/s10103-022-03600-5

Cited by 5 publications

(3 citation statements)

References 41 publications

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“…An important advantage of this study is that it uses various photo emitting devices that achieve a cumulative therapeutic eff ect, which generally gives a better result -both in terms of reducing pain symptoms and overcoming contractures, compared to mono laser applications [23,24,25]. Some devices combine a red wavelength with a near infrared (NIR) wavelength on the basis that the combination of two wavelengths can have an additive eff ect.…”

Section: Discussionmentioning

confidence: 99%

“…It provides both accelerated tissue healing and pain relief with cumulative eff ects -increase in microcirculation resulting in the relief of minor muscle and joint aches, stiff ness and helps with the relaxation of muscles [22]. Light energy can be generated by a variety of devices such as laser diodes or super-bright LEDs called superluminous diodes (SLD) [23][24][25].…”

Section: Introductionmentioning

confidence: 99%

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Management of Pain Symptoms and Contractures in Patients with Chronic Temporomandibular Disorders and Psychosocial Comorbidities Using Gaalas Phototherapy

Svecshtarov,

Prodanova,

Nencheva-Sveshtarova

2023

Acta Medica Bulgarica

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The most important clinical indicators of temporomandibular disorders (TMD) are pain in the temporomandibular joints, masticatory and cervical muscles, as well as a reduction in the opening capacity of the mouth. Psychosocial factors have a significant impact in the persistence of the disease and should be taken in consideration in the treatment plan. The aim of the present study was to perform clinical and statistical evaluation on the management of pain symptoms and overcome of pronounced arthro- and myogenic mandibular contractures in GAD 7 positive patients with chronic temporomandibular disorders using combined irradiation with infrared gallium-aluminum-arsenide laser (785 nm), superluminescent visible red (633 nm) and infrared (880 nm) light emitting devices. Materials and methods. The study included 62 individuals with various types of temporomandibular disorders, which were established using the latest diagnostic criteria – DC/TMD, 2014, revision 2020. Fifteen out of 62 patients responded positively to the GAD 7 questionnaire, which indicates depression and/or anxiety. In 8 out of these 15 cases, the presence of pain symptoms, mandibular contractures and psychosocial comorbidities exceeded 6 months. According to DC/TMD standards, these are patients with chronic temporomandibular disorders and they were the target group for our study. The average interincisal distance from this eight-member group was 27.62 mm (SD – 8.17). Results. The Student t-test for the dependent samples showed a significant reduction in VAS pain scores and an increased interincisal distance after phototherapy procedures. Conclusions. Combined phototherapy has proven to be an effective treatment of mandibular contractures, joint and muscle pain in TMD patients with psychosocial comorbid conditions.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Management of Pain Symptoms and Contractures in Patients with Chronic Temporomandibular Disorders and Psychosocial Comorbidities Using Gaalas Phototherapy

Svecshtarov,

Prodanova,

Nencheva-Sveshtarova

2023

Acta Medica Bulgarica

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“…As an emergency, physiotherapy, splint therapy, pharmacotherapy, arthrocentesis, and intra-articular hyaluronan should be considered first, as these methods do not require a donor site [ 91 , 95 , 98 ]. Good results in pain relief in patients that were diagnosed with temporomandibular disorders have also been shown for infrared light photobiomodulation [ 99 , 100 , 101 , 102 , 103 ]. Increased muscle tension can result in muscle pain that is difficult to differentiate from joint pain the more that the limitation of opening the mouth also coexists [ 26 , 91 , 96 ].…”

Section: Discussionmentioning

confidence: 99%

Autologous Stem Cells Transplants in the Treatment of Temporomandibular Joints Disorders: A Systematic Review and Meta-Analysis of Clinical Trials

Chęciński¹,

Chęcińska

Turosz³

et al. 2022

Cells

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This systematic review aims to analyze the outcomes of the treatment of temporomandibular joint (TMJ) articular pain (AP) and restricted maximum mouth opening (MMO) with intra-articular administration of mesenchymal stem cells (MSCs). The inclusion criteria allowed primary studies involving AP and/or MMO pre-treatment and post-intervention values. Medical databases that were covered by ACM Digital, BASE, EBSCOhost, Google Scholar, PubMed, Scopus, and Web of Science engines were searched. The risk of bias was assessed with RoB 2 and ROBINS-I tools. The results were tabulated, plotted, and analyzed for regression. A total of 5 studies involving 51 patients/69 TMJs were identified, and 4 studies on 50 patients/67 TMJs were synthesized. Interventions were each time effective in decreasing AP and increasing MMO in a 6-month follow-up period by an average of about 85% and over 40%, respectively. Regression analysis showed a good fit of the logarithmic model for AP relief (5.8 − 0.8 ln x; R2 = 0.90) and MMO increase (33.5 + 2.4 ln x; R2 = 0.89). The results for AP and MMO were based on 3 studies in 39 patients and 4 studies in 50 patients, respectively, all at high risk of bias. The intra-articular administration of MSCs to TMJs, based on weak evidence, may be highly effective in reducing AP and improving MMO. This study received no funding.

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Does photobiomodulation alter mitochondrial dynamics?

Trajano,

Siqueira,

Rodrigues

et al. 2024

Photochem & Photobiology

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Mitochondrial dysfunction is one of the leading causes of disease development. Dysfunctional mitochondria limit energy production, increase reactive oxygen species generation, and trigger apoptotic signals. Photobiomodulation is a noninvasive, nonthermal technique involving the application of monochromatic light with low energy density, inducing non‐thermal photochemical effects at the cellular level, and it has been used due to its therapeutic potential. This review focuses on the mitochondrial dynamic's role in various diseases, evaluating the possible therapeutic role of low‐power lasers (LPL) and light‐emitting diodes (LED). Studies increasingly support that mitochondrial dysfunction is correlated with severe neurodegenerative diseases such as Parkinson's, Huntington's, Alzheimer's, and Charcot–Marie‐Tooth diseases. Furthermore, a disturbance in mitofusin activity is also associated with metabolic disorders, including obesity and type 2 diabetes. The effects of PBM on mitochondrial dynamics have been observed in cells using a human fibroblast cell line and in vivo models of brain injury, diabetes, spinal cord injury, Alzheimer's disease, and skin injury. Thus, new therapies aiming to improve mitochondrial dynamics are clinically relevant. Several studies have demonstrated that LPL and LED can be important therapies to improve health conditions when there is dysfunction in mitochondrial dynamics.

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Simultaneous red and infrared light-emitting diodes reduced pain in individuals with temporomandibular disorder: a randomized, controlled, double-blind, clinical trial

Cited by 5 publications

References 41 publications

Management of Pain Symptoms and Contractures in Patients with Chronic Temporomandibular Disorders and Psychosocial Comorbidities Using Gaalas Phototherapy

Management of Pain Symptoms and Contractures in Patients with Chronic Temporomandibular Disorders and Psychosocial Comorbidities Using Gaalas Phototherapy

Autologous Stem Cells Transplants in the Treatment of Temporomandibular Joints Disorders: A Systematic Review and Meta-Analysis of Clinical Trials

Does photobiomodulation alter mitochondrial dynamics?

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