Simultaneous Recurrent Multiple Chemodectomas

Casterline, Peter F.; Jaques, Darrell A.

doi:10.1001/archotol.1978.00790030043010

Cited by 6 publications

(3 citation statements)

References 12 publications

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“…No nonfamilial patients demonstrating this multicentric configuration of tumors have been reported. Bilateral glomus jugulare tumors have been reported in six familial patients 36–40 and in only one nonfamilial case 41 ; another nonfamilial case has been treated but not reported by one of the authors (c.m.l. ).…”

Section: Introductionmentioning

confidence: 89%

Genetic Analysis in the Diagnosis of Familial Paragangliomas

et al. 2000

The Laryngoscope

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Objectives In the management of two related patients with multicentric glomus jugulare tumors, given the incidence of 1:30,000 with approximately 20% familial cases, our objective was to review the genetic characteristics and inheritance patterns of these tumors and to determine what molecular genetic screening possibilities exist for the phenotypically normal family members. In addition, our aim was to review the incidence of various multicentric paraganglioma (PGL) tumor location combinations. Methods Molecular genetic linkage analysis testing was performed on the 2 patients and 14 other unaffected family members. We report the results of this screening and review the literature on the incidence and genetics of paragangliomas. Results The inheritance pattern in the literature demonstrates autosomal dominant transmission with maternal imprinting (inactivation). The proclivity for multicentric origin increases to 26% in familial cases, as reflected in our patients. In addition to the two patients, four unaffected family members demonstrated the presence of the disease haplotype at chromosome band 11q23, which indicates a very high likelihood of developing a paraganglioma, given the highly penetrant nature of the disease. Conclusions It is clear that the familial PGL gene locus is situated at chromosome 11q23. The gene itself and its exact degree of penetrance, however, still await identification. Since early detection of paragangliomas reduces the incidence of morbidity and mortality, genotypic analysis as a screening tool in families of affected patients should play a front‐line diagnostic role, leading to more timely and cost‐effective patient management.

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Section: Introductionmentioning

confidence: 89%

Genetic Analysis in the Diagnosis of Familial Paragangliomas

et al. 2000

The Laryngoscope

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“…They arise from specialized neural crest cells associated with autonomic ganglia 4) . So far to our knowledge only seven cases with concurrent carotid body and glomus jugulare tumor was reported 3,5,6,9,14,22,24) .…”

Section: Definitionmentioning

confidence: 95%

Synchronous Carotid Body and Glomus Jugulare Tumors : A Case Report and Review of Literature

Rahman,

Venkataram,

Habib

et al. 2024

J Korean Neurosurg Soc

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Paragangliomas are rare neuroendocrine tumors that are usually benign in nature. They may be either familial or sporadic in their occurrence. Numerous neuroendocrine tumors are collectively included under the umbrella of paragangliomas. Among them, carotid body tumors and glomus jugulare tumors are extremely rare. Thus, we present a rare case of 29-year-old male who was admitted with hearing difficulties and tinnitus in the left ear, with swelling on the left side of the neck. Based on clinical and radiological findings, a diagnosis of left-sided glomus jugulare with carotid body tumor was made. The patient underwent a twostage surgery with an interval of approximately 2 months. Histopathology revealed a paraganglioma. Herein, we present the clinical features, imaging findings, management, and a brief review of literature on the classification, evaluation, and management of carotid body and glomus jugulare tumors. Paraganglioma is a slow-growing tumor. The synchronous occurrence of carotid body and glomus jugulare tumors is infrequent. Microsurgical resection remains the primary treatment modality. Therefore, our patient underwent two-stage surgery. The rarity of occurrence and the proximity and adherence to vital neurovascular structures have resulted in the treatment of paragangliomas remaining a challenge.

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“…Usually it is better to illustrate the diversity of the holdings through a series of thematic exhibits than to squeeze too much into a single large display. " 18 Before the RAC's exhibit program was standardized, there were times when too many documents were displayed, or there was a last-minute decision to add or remove items. The chart has eliminated indecision when it comes to the number of items to be included, which helps when developing the overall vision for the exhibit.…”

Section: Increasing Collaboration In the Exhibit Processmentioning

confidence: 99%

Voila!: The Rockefeller Archive Center's Exhibit Creation Process

Vassari

2018

Collections

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The Rockefeller Archive Center (RAC) in Sleepy Hollow, New York, hosts groups ranging from foundation staff to college-level classes. Over the course of a year, the RAC hosts approximately 30 visiting groups that include from as few as 10 people to as many as 45. The aim is to engage visiting groups with the RAC's vast collections by creating hands-on, tailored exhibits. The RAC has created policies and procedures, exhibit guides, and workflow templates that allow for documentation of each exhibit and encourage inclusiveness and transparency among staff. Employing a new, standardized approach by using these tools has made all phases of the exhibit process more efficient and allows the RAC to provide a rich, immersive archival experience for visitors. This article offers a case study in standardized exhibit creation that may benefit professionals in other institutions who are seeking to develop work processes and policies without diminishing the visitor experience.

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Simultaneous Recurrent Multiple Chemodectomas

Cited by 6 publications

References 12 publications

Genetic Analysis in the Diagnosis of Familial Paragangliomas

Genetic Analysis in the Diagnosis of Familial Paragangliomas

Synchronous Carotid Body and Glomus Jugulare Tumors : A Case Report and Review of Literature

Voila!: The Rockefeller Archive Center's Exhibit Creation Process

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