Simultaneous Reconstruction of Activity and Attenuation in Time-of-Flight PET

Rezaei, Ahmadreza; Defrise, Michel; Bal, Girish; Michel, Christian; Conti, Maurizio; Watson, Charles C.; Nuyts, Johan

doi:10.1109/tmi.2012.2212719

Cited by 235 publications

(158 citation statements)

References 31 publications

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“…The current availability of powerful software makes these computations sometimes demanding, technically possible and mathematically stable [32]. These techniques also have some important limitations: 1) a critical amount of radioactivity must be present in the anatomical regions in order to calculate regional values of the attenuation coefficient.…”

Section: ) Methods Based On the Combination Of Pet Emission Data Andmentioning

confidence: 99%

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MR-Based Attenuation Correction in Brain PET/MR Studies: A Short Review

Giovannini¹,

Giovacchini²,

Nicolosi³

et al. 2017

J Diagn Imaging Ther

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In the previous few years we have witnessed to an increased diffusion of positron emission tomography/magnetic resonance (PET/MR) tomographs and equally an increasing number of clinical studies with these hybrid devices in both the neurological and psychiatric fields. Although PET/MR contains many features that facilitate its application in brain imaging, accurate quantification is still hindered by difficulties in developing MR-based attenuation correction methods. In this paper, we have reviewed the three main methods currently used for attenuation correction in PET/MR: namely segmentation-based methods including, atlas and template. In addition to procedures based on the combination of PET emission data and MR anatomical information (or reconstruction-based methods). Many research centers are actively working to refine available methods and substantial improvements are expected in future years. Clinical studies using PET/MR focused mainly on neurooncological and neurodegenerative disorders. Simultaneous PET/MR was shown to provide very promising scientific results and to be logistically more convenient for patients. More studies are expected in the near future, as the availability of PET/MR and the clinical use of new tracers for neurodegenerative disorders will further increase.

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Section: ) Methods Based On the Combination Of Pet Emission Data Andmentioning

confidence: 99%

“…3) Scatter correction is more difficult and it can induce crosstalk between the estimation of attenuation and emission. Time-of-flight technology may improve the accuracy of the estimation of the attenuation map [32].…”

Section: ) Methods Based On the Combination Of Pet Emission Data Andmentioning

confidence: 99%

MR-Based Attenuation Correction in Brain PET/MR Studies: A Short Review

Giovannini¹,

Giovacchini²,

Nicolosi³

et al. 2017

J Diagn Imaging Ther

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show abstract

“…Emission-based techniques form the last category of algorithms and have gained substantial momentum during the last decade. They are now recognized as valuable approaches for estimation of the attenuation map in PET/MRI through the simultaneous estimation of activity and attenuation within a maximum-likelihood (MLAA) framework [51]. However, these techniques suffer from cross-talk, depend on tracer distribution, and are susceptible to counting statistics.…”

Section: Mri-guided Attenuation Correction In Pet/mrimentioning

confidence: 99%

The Promise of Hybrid PET\/MRI: Technical advances and clinical applications

Zaidi

Becker

2016

IEEE Signal Process. Mag.

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D uring the last few decades, positron emission tomography (PET)-based molecular imaging has advanced eleg antly and steadily gained importance in the clinical and research arenas. However, the lack of structural information provided by this imaging modality motivated its correlation with structural imaging techniques such as X-ray computed tomography (CT) or magnetic resonance imaging (MRI), which are well established in the clinical setting. The additional capability of simultaneous acquisition of PET and MRI data bridges the gap between molecular and morphologic diagnoses. Since diagnostic imaging methods evolve from the anatomical to the molecular level, the mission of multimodal and multiparametric imaging increasingly becomes more essential. Since 2010, whole-body hybrid PET/MRI has been investigated in the clinical setting for clinical diagnosis and staging, treatment response monitoring, and radiation therapy treatment planning of a wide range of malignancies. However, quantitative PET/MRI is still challenged by the lack of accurate and robust attenuation and motion compensation strategies to enable the production of artifact-free and quantitative PET images. This article briefly summarizes the historical development of PET/MRI and gives Technical advances and clinical applications ©graphic stock 68 IEEE SIgnal ProcESSIng MagazInE | May 2016 | an overview of the state of the art and recent advances in the design and construction of clinical systems. Progress in quantitative imaging, including MRI-guided image reconstruction and correction, and potential clinical applications of this novel technology are also discussed.

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“…4,7 A similar approach has been also applied to PET/MR. 13 Although some useful results have been obtained, these methods are generally disappointing because of the cross talk. This is essentially due to the lack of attenuation information in the emission measurement to uniquely determine the ACFs.…”

mentioning

confidence: 99%

“…One such method is the maximum-likelihood activity and attenuation estimation technique, which simultaneously estimates activity and attenuation images, applied to TOF PET. 13 Salomon et al 21 also proposed a related maximum-likelihood (ML) algorithm to assign attenuation values to MRI regions based on TOF PET data. A second group of methods comprises ML techniques applied to jointly estimate the ACFs instead of the attenuation image.…”

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confidence: 99%

Joint estimation of activity image and attenuation sinogram using time-of-flight positron emission tomography data consistency condition filtering

Kim

et al. 2017

J. Med. Imag

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Abstract. Attenuation correction is essential for quantitative reliability of positron emission tomography (PET) imaging. In time-of-flight (TOF) PET, attenuation sinogram can be determined up to a global constant from noiseless emission data due to the TOF PET data consistency condition. This provides the theoretical basis for jointly estimating both activity image and attenuation sinogram/image directly from TOF PET emission data. Multiple joint estimation methods, such as maximum likelihood activity and attenuation (MLAA) and maximum likelihood attenuation correction factor (MLACF), have already been shown that can produce improved reconstruction results in TOF cases. However, due to the nonconcavity of the joint log-likelihood function and Poisson noise presented in PET data, the iterative method still requires proper initialization and well-designed regularization to prevent convergence to local maxima. To address this issue, we propose a joint estimation of activity image and attenuation sinogram using the TOF PET data consistency condition as an attenuation sinogram filter, and then evaluate the performance of the proposed method using computer simulations.

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Simultaneous Reconstruction of Activity and Attenuation in Time-of-Flight PET

Cited by 235 publications

References 31 publications

MR-Based Attenuation Correction in Brain PET/MR Studies: A Short Review

MR-Based Attenuation Correction in Brain PET/MR Studies: A Short Review

The Promise of Hybrid PET\/MRI: Technical advances and clinical applications

Joint estimation of activity image and attenuation sinogram using time-of-flight positron emission tomography data consistency condition filtering

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