Simultaneous Quantitative Measurements of absolute Gallbladder Storage and Emptying During Fasting and Eating in Humans

Lanzini, Alberto; Jazrawi, R. P.; Northfield, T.C.

doi:10.1016/0016-5085(87)90957-7

Cited by 70 publications

(29 citation statements)

References 17 publications

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“…18,20 Using planar images obtained before and after cholecystokinin-8 administration, the gallbladder ejection fraction was determined (Table 1). With the exception of subject 3, remarkably large and consistent ejection fractions were obtained.…”

Section: Resultsmentioning

confidence: 99%

A novel method for the determination of biliary clearance in humans

Ghibellini

Johnson

Kowalsky

et al. 2004

AAPS J

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Biliary excretion is an important route of elimination and the biliary tract is a potential site of toxicity for many drugs and xenobiotics. Quantification of biliary excretion in healthy human volunteers is logistically challenging and is rarely defined during drug development. The current study uses a novel oroenteric tube coupled with a specialized clinical protocol to examine the pharmacokinetics of 99m Technetium (Tc-99m) mebrofenin, a compound that undergoes rapid hepatic uptake and extensive biliary excretion. A custommade multilumen oroenteric tube was positioned in the duodenum of healthy human volunteers. Subjects were positioned under a gamma camera and 2.5 mCi of Tc-99m mebrofenin was administered intravenously. Duodenal aspirates, blood samples, and urine were collected periodically for 3 hours. Two hours after Tc-99m mebrofenin administration, the gallbladder was contracted with an intravenous infusion of cholecystokinin-8. Gamma scintigraphy was used to determine the gallbladder ejection fraction in each subject. Total systemic clearance of Tc-99m mebrofenin approximated liver blood flow (Cl total 17.3 ± 1.7 mL/min/kg), and 35% to 84% of the Tc-99m mebrofenin dose was recovered in bile. However, when the data were corrected for the gallbladder ejection fraction, 71% to 92% of the excreted Tc-99m mebrofenin dose was recovered. This novel oroenteric tube and clinical protocol provide a useful method to quantify biliary excretion of xenobiotics in healthy human volunteers.

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Section: Resultsmentioning

confidence: 99%

A novel method for the determination of biliary clearance in humans

Ghibellini

Johnson

Kowalsky

et al. 2004

AAPS J

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“…A similar pattern has also been reported for hepatic bile acid secretion rate in studies involving a hepatic bile marker in addition to duodenal perfusion of intestinal recovery markers [94,95]. We have recently studied in detail the mechanism involved in these effects by using a gallbladder bile marker (99mTc HIDA) in addition to a hepatic bile marker (indocyanine green), and absorbable duodenal recovery markers (radiolabelled cholesterol and phospholipid) as well as a non-absorbable recovery marker (polyethylene glycol) [96,97]. These modifications enabled us to measure gallbladder motor function simultaneously with duodenal outputs and hepatic secretion rate for all three biliary lipids during an evening meal and subsequent overnight fasting.…”

Section: Cholesterol Saturation Of Hepatic Bilementioning

confidence: 99%

Biliary lipid secretion in man

Lanzini

Northfield

1991

Eur J Clin Investigation

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“…33 arecent study conducted by Verma et al (2013) suggested the utility of real-time ultrasonogram in selecting patients with poor contractile (<40%) gallbladder for cholecystectomy. 34 Kalloo et al suggested that gallbladder ejection fraction cannot be used to diagnose sphincter of Oddi dysfunction before cholecystectomy since study had a sensitivity of 33%, a specificity of 63%, and a positive predictive value of 25% and regression analysis revealed a poor correlation between sphincter pressure and gallbladder ejection fraction 35 .…”

Section: Non-invasive Diagnostic Testsmentioning

confidence: 99%

Sphincter of Oddi disorder (SOD): Is it necessary to investigate and treat?

Kumar¹

2015

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Sphincter of Oddi disorder (SOD) is a part of functional gastrointestinal disorder which is a non-calculous obstructive disorder. This disease is more common in middle-aged women with a prevalence of around 1.5% but in patients with post-cholecystectomy syndrome (PCS) the prevalence rate is markedly higher (9-55%). This high variability maybe attributed to lack of uniformity in patient selection criteria, definition of SOD, and the diagnostic method used.Abdominal pain is the most common symptom occurring due to obstruction at the SO leading to ductal hypertension, ischemia from spastic contraction and hypersensitivity of papilla.Clinical diagnosis of SOD can be achieved by Rome III criteria. Various classifications are used (Milwaukee billiary and modified Milwaukee group classification) for billiary and pancreatic SOD. Not a single non-invasive method is diagnostic. Sphincter of Oddimanometry (SOM) is the gold standard method for evaluating and deciding the management of an SOD patient. The symptomatic relief rate varies from 55% to 95%, so risk-benefit ratio should be evaluated with each patient.

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Simultaneous Quantitative Measurements of absolute Gallbladder Storage and Emptying During Fasting and Eating in Humans

Cited by 70 publications

References 17 publications

A novel method for the determination of biliary clearance in humans

A novel method for the determination of biliary clearance in humans

Biliary lipid secretion in man

Sphincter of Oddi disorder (SOD): Is it necessary to investigate and treat?

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