Simultaneous quantification of steroid hormones and endocannabinoids (ECs) in human hair using an automated supported liquid extraction (SLE) and LC-MS/MS – Insights into EC baseline values and correlation to steroid concentrations

Voegel, Clarissa D.; Baumgartner, Markus R.; Kræmer, Thomas; Wüst, Stefan; Binz, Tina M.

doi:10.1016/j.talanta.2020.121499

Cited by 51 publications

(35 citation statements)

References 44 publications

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“…Six different blank hair preparation strategies for endogenous compound quantification (surrogate analyte, standard addition, background correction, stripped matrix, solvent calibration, and artificial matrix) were compared by Voegel et al. ( 54 ) and Thakare et al. ( 55 ).…”

Section: Discussionmentioning

confidence: 99%

Measurement of 7-dehydrocholesterol and cholesterol in hair can be used in the diagnosis of Smith-Lemli-Opitz syndrome

Luo

Zhang

et al. 2022

Journal of Lipid Research

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Section: Discussionmentioning

confidence: 99%

Measurement of 7-dehydrocholesterol and cholesterol in hair can be used in the diagnosis of Smith-Lemli-Opitz syndrome

Luo

Zhang

et al. 2022

Journal of Lipid Research

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“…Finally, a new methodology called "surrogate analyte approach (SAA)" should be mentioned in comparison with the SAM [84][85][86][87][88][89][90][91][92]. In this method, no blank matrix is also required, but stable isotope-labeled target compound(s) is/ are essential to create calibration curve(s) and to gain validation data.…”

Section: Discussionmentioning

confidence: 99%

The standard addition method and its validation in forensic toxicology

et al. 2021

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Purpose In the quantitative forensic toxicological analyses using instruments, major methods to be employed are conventional matrix-matched calibration method (MMCM). However, nowadays, the needs for using the standard addition methods (SAM) are increasing. In spite of this situation, there are no reports of the guidelines for the validations of SAM. In this review, the principle, how to perform it, advantages, disadvantages, reported application data, and the details of validation procedures for the SAM are described. Methods Various databases such as SciFinder, Google and Google Scholar were utilized to collect relevant reports referring to the SAM. The long experiences of our research group on the SAM were also included in this review. Results Although the experimental procedures for the SAM are much more laborious than those of the MMCM, the SAM is essential to quantify target xenobiotic(s) in special matrices such as human solid tissues or biles, which remarkably interfere with the usual quantitative analyses. The validation methods for the SAM have been also proposed for the cases in the absence of the blank matrices. Conclusions To our knowledge, this is the first presentation of detailed SAM procedure and its validation, which will facilitate the use of the SAM in forensic toxicology. Especially for its validation, new simple methods have been proposed.

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“…The expression and/or localisation of functional CB 2 protein has also been reported for mast cells, modulating their initial activation, or downregulating their activity post their initial activation, an activity change which can in turn provoke an anti-inflammatory response [75]. Anandamide and 2-AG, as well as their metabolic enzymes, are detectable in blood [76,77], hair [78][79][80], saliva [81][82][83], breast milk [84,85], and reproductive fluids [84,86]. Compounded with the peripheral anti-inflammatory response, CB 2 receptor agonists can mediate peripheral antinociception without the psychotropic CNS effects associated with phytocannabinoid CB 1 receptor binding [87,88].…”

Section: The Endocannabinoid System and Its Associated Molecular Targmentioning

confidence: 95%

Cannabis sativa: Interdisciplinary Strategies and Avenues for Medical and Commercial Progression Outside of CBD and THC

Oultram

Pegler

Bowser³

et al. 2021

Biomedicines

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Cannabis sativa (Cannabis) is one of the world’s most well-known, yet maligned plant species. However, significant recent research is starting to unveil the potential of Cannabis to produce secondary compounds that may offer a suite of medical benefits, elevating this unique plant species from its illicit narcotic status into a genuine biopharmaceutical. This review summarises the lengthy history of Cannabis and details the molecular pathways that underpin the production of key secondary metabolites that may confer medical efficacy. We also provide an up-to-date summary of the molecular targets and potential of the relatively unknown minor compounds offered by the Cannabis plant. Furthermore, we detail the recent advances in plant science, as well as synthetic biology, and the pharmacology surrounding Cannabis. Given the relative infancy of Cannabis research, we go on to highlight the parallels to previous research conducted in another medically relevant and versatile plant, Papaver somniferum (opium poppy), as an indicator of the possible future direction of Cannabis plant biology. Overall, this review highlights the future directions of cannabis research outside of the medical biology aspects of its well-characterised constituents and explores additional avenues for the potential improvement of the medical potential of the Cannabis plant.

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Simultaneous quantification of steroid hormones and endocannabinoids (ECs) in human hair using an automated supported liquid extraction (SLE) and LC-MS/MS – Insights into EC baseline values and correlation to steroid concentrations

Cited by 51 publications

References 44 publications

Measurement of 7-dehydrocholesterol and cholesterol in hair can be used in the diagnosis of Smith-Lemli-Opitz syndrome

Measurement of 7-dehydrocholesterol and cholesterol in hair can be used in the diagnosis of Smith-Lemli-Opitz syndrome

The standard addition method and its validation in forensic toxicology

Cannabis sativa: Interdisciplinary Strategies and Avenues for Medical and Commercial Progression Outside of CBD and THC

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